論文

査読有り
2010年3月

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

JOURNAL OF NEUROSCIENCE
  • Itaru Imayoshi
  • ,
  • Masayuki Sakamoto
  • ,
  • Masahiro Yamaguchi
  • ,
  • Kensaku Mori
  • ,
  • Ryoichiro Kageyama

30
9
開始ページ
3489
終了ページ
3498
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.4987-09.2010
出版者・発行元
SOC NEUROSCIENCE

Activation of Notch signaling induces the expression of transcriptional repressor genes such as Hes1, leading to repression of proneural gene expression and maintenance of neural stem/progenitor cells. However, a requirement for Notch signaling in the telencephalon was not clear, because in Hes1; Hes3; Hes5 triple-mutant mice, neural stem/progenitor cells are depleted in most regions of the developing CNS, but not in the telencephalon. Here, we investigated a role for Notch signaling in the telencephalon by generating tamoxifen-inducible conditional knock-out mice that lack Rbpj, an intracellular signal mediator of all Notch receptors. When Rbpj was deleted in the embryonic brain, almost all telencephalic neural stem/progenitor cells prematurely differentiated into neurons and were depleted. When Rbpj was deleted in the adult brain, all neural stem cells differentiated into transit-amplifying cells and neurons. As a result, neurogenesis increased transiently, but 3 months later all neural stem cells were depleted and neurogenesis was totally lost. These results indicated an absolute requirement of Notch signaling for the maintenance of neural stem cells and a proper control of neurogenesis in both embryonic and adult brains.

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.4987-09.2010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20203209
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000275191000035&DestApp=WOS_CPL
ID情報
  • DOI : 10.1523/JNEUROSCI.4987-09.2010
  • ISSN : 0270-6474
  • PubMed ID : 20203209
  • Web of Science ID : WOS:000275191000035

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