2009年12月
Dynamic regulation of Notch signaling in neural progenitor cells
CURRENT OPINION IN CELL BIOLOGY
- ,
- ,
- ,
- 巻
- 21
- 号
- 6
- 開始ページ
- 733
- 終了ページ
- 740
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ceb.2009.08.009
- 出版者・発行元
- CURRENT BIOLOGY LTD
In the developing nervous system, differentiating neurons express Delta and activate Notch signaling in their neighboring cells. As a result of Notch activation, neuronal differentiation is inhibited in neighboring cells and they remain neural progenitor cells. Thus, differentiation of neurons and maintenance of neural progenitor cells are well balanced owing to Notch signaling. Recent studies revealed that Notch signaling is under the control of more complex and dynamic regulation than previously thought, such as cell cycle dependent activation and oscillating gene expression. We discuss here recent advances in understanding how Notch signaling is regulated in the developing nervous system and what outcome each type of regulation of Notch signaling leads to. We highlight the role of Notch signaling in proliferation and differentiation of neural progenitor cells.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ceb.2009.08.009
- ISSN : 0955-0674
- PubMed ID : 19783418
- Web of Science ID : WOS:000272936500003