論文

国際誌
2021年8月1日

Rapamycin Accelerates Axon Regeneration Through Schwann Cell-mediated Autophagy Following Inferior Alveolar Nerve Transection in Rats.

Neuroscience
  • Takanobu Inada
  • ,
  • Hitoshi Sato
  • ,
  • Yoshinori Hayashi
  • ,
  • Suzuro Hitomi
  • ,
  • Akihiko Furukawa
  • ,
  • Masatoshi Ando
  • ,
  • Eri Oshima
  • ,
  • Jo Otsuji
  • ,
  • Naoto Taguchi
  • ,
  • Ikuko Shibuta
  • ,
  • Hiromasa Tsuda
  • ,
  • Koichi Iwata
  • ,
  • Tatsuo Shirota
  • ,
  • Masamichi Shinoda

468
開始ページ
43
終了ページ
52
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuroscience.2021.05.033

Sensory disturbance in the orofacial region owing to trigeminal nerve injury is caused by dental treatment or accident. Commercially available therapeutics are ineffective for the treatment of sensory disturbance. Additionally, the therapeutic effects of rapamycin, an allosteric inhibitor of mammalian target of rapamycin (mTOR), which negatively regulates autophagy, on the sensory disturbance are not fully investigated. Thus, we investigated the therapeutic effects of rapamycin on the sensory disturbance in the mandibular region caused by inferior alveolar nerve (IAN) transection (IANX) in rats. The expression levels of the phosphorylated p70S6K, a downstream molecule of mTOR, in the proximal and distal stumps of the transected IAN were significantly reduced by rapamycin administration to the injured site. Conversely, the increments of both Beclin 1 and microtubule-associated protein-1 light chain 3-II protein levels in the proximal and distal stumps of the transected IAN was induced by rapamycin administration. Immunohistochemical analyses revealed that Beclin 1 was located in Schwann cells in the proximal stump of the IAN. Accumulation of myelin protein zero and myelin basic protein in the proximal and distal stumps of the IAN was significantly reduced by rapamycin administration. Rapamycin administration facilitated axon regeneration after IANX and increased the number of brain-derived neurotrophic factor positive neurons in the trigeminal ganglion. Thus, recovery from sensory disturbance in the lower lip caused by IANX was markedly facilitated by rapamycin. These findings suggest that rapamycin administration is a promising treatment for the sensory disturbance caused by IANX.

リンク情報
DOI
https://doi.org/10.1016/j.neuroscience.2021.05.033
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34102263
ID情報
  • DOI : 10.1016/j.neuroscience.2021.05.033
  • PubMed ID : 34102263

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