2015年12月
Inhibition of the 26S proteasome by peptide mimics of the coiled-coil region of its ATPase subunits
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ,
- 巻
- 468
- 号
- 1-2
- 開始ページ
- 143
- 終了ページ
- 150
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2015.10.144
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Regulation of proteasomal degradation is an indispensable tool for biomedical studies. Thus, there is demand for novel proteasome inhibitors. Proteasomal degradation requires formation of coiled-coil structure by the N-terminal region of ATPase subunits of the proteasome cap. Here we show that peptides that mimic the N-terminal coiled-coil region of ATPase subunits interfere with proteasome function. These results suggest that coiled-coil peptides represent promising new proteasome inhibitors and that N-terminal coiled-coil regions of ATPase subunits are targets for proteasome inhibition. (C) 2015 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bbrc.2015.10.144
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702217888572787
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26522225
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000366240800023&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bbrc.2015.10.144
- ISSN : 0006-291X
- eISSN : 1090-2104
- J-Global ID : 201702217888572787
- PubMed ID : 26522225
- Web of Science ID : WOS:000366240800023