論文

査読有り 国際誌
2018年9月3日

Classic Hodgkin Lymphoproliferative Diseases Clonally Unrelated to B-Chronic Lymphocytic Leukemia Successfully Treated with Bendamustine Plus Rituximab.

Cancers
  • Shinya Rai
  • ,
  • Hirokazu Tanaka
  • ,
  • Ko Fujimoto
  • ,
  • Takahiro Kumode
  • ,
  • Hiroaki Inoue
  • ,
  • Yasuhiro Taniguchi
  • ,
  • Yasuyoshi Morita
  • ,
  • J Luis Espinoza
  • ,
  • Yoichi Tatsumi
  • ,
  • Takashi Ashida
  • ,
  • Ryota Matsuoka
  • ,
  • Yukie Yara Kikuti
  • ,
  • Naoya Nakamura
  • ,
  • Itaru Matsumura

10
9
記述言語
英語
掲載種別
DOI
10.3390/cancers10090304

A 62-year-old male was diagnosed with chronic lymphocytic leukemia (CLL) and treated with a fludarabine-containing regimen which maintained the disease in a partial response. Nine years after diagnosis, a rapidly growing systemic lymphadenopathy was observed, and a biopsy specimen revealed the presence of typical Hodgkin/Reed-Sternberg (HRS) cells, surrounded by T-lymphocytes and CLL cells. Sequencing analysis of the germline complementary determining region 3 (CDR3) region of the immunoglobulin heavy chain (IGH) gene showed that the Hodgkin/Reed-Sternberg cells were clonally unrelated to the preexisting CLL cells and the HRS cells were composed of five different clones, leading to the molecular diagnosis of de novo lymphocyte-rich classic Hodgkin lymphoproliferative diseases (LPDs) with small lymphocytic lymphoma (SLL). As the initial treatment was neither effective for classic Hodgkin LPDs nor for SLL, Bendamustine, Rituximab (BR) was started and complete remission was achieved, which has continued for more than one year so far. BR may be a good therapeutic option for both entities without causing hematological toxicity.

リンク情報
DOI
https://doi.org/10.3390/cancers10090304
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30177612
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162540

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