論文

査読有り
2007年9月

Formation of an ascorbate-apatite composite layer on titanium

BIOMEDICAL MATERIALS
  • Atsuo Ito
  • ,
  • Yu Sogo
  • ,
  • Yuko Ebihara
  • ,
  • Masahiro Onoguchi
  • ,
  • Ayako Oyane
  • ,
  • Noboru Ichinose

2
3
開始ページ
S181
終了ページ
S185
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1088/1748-6041/2/3/S17
出版者・発行元
IOP PUBLISHING LTD

An ascorbate - apatite composite layer was successfully formed on NaOH- and heat-treated titanium by coprecipitating L-ascorbic acid phosphate and low-crystalline apatite in a supersaturated calcium phosphate solution at 37 degrees C for 48 h. The supersaturated calcium phosphate solutions used have chemical compositions attainable by mixing infusion fluids officially approved for clinical use. The amount of immobilized L-ascorbic acid phosphate ranged from 1.0 to 2.3 mu g mm(-2), which is most likely to be sufficient for the in vitro osteogenic differentiation of mesenchymal stem cells on titanium. Since ascorbate is important for the collagen synthesis and subsequent osteogenesis of mesenchymal stem cells, titanium coated with the ascorbate - apatite composite layer would be useful as a scaffold in bone tissue engineering and as a bone substitute.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1088/1748-6041/2/3/S17
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249597800018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1088/1748-6041/2/3/S17
  • ISSN : 1748-6041
  • Web of Science ID : WOS:000249597800018

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