論文

査読有り
2021年1月

Association analysis of repetitive elements and R-loop formation across species

Mobile DNA
  • Chao Zeng
  • ,
  • Masahiro Onoguchi
  • ,
  • Michiaki Hamada

12
3
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s13100-021-00231-5
出版者・発行元
Springer Science and Business Media LLC

<title>Abstract</title><sec>
<title>Background</title>
Although recent studies have revealed the genome-wide distribution of R-loops, our understanding of R-loop formation is still limited. Genomes are known to have a large number of repetitive elements. Emerging evidence suggests that these sequences may play an important regulatory role. However, few studies have investigated the effect of repetitive elements on R-loop formation.


</sec><sec>
<title>Results</title>
We found different repetitive elements related to R-loop formation in various species. By controlling length and genomic distributions, we observed that satellite, long interspersed nuclear elements (LINEs), and DNA transposons were each specifically enriched for R-loops in humans, fruit flies, and Arabidopsis thaliana, respectively. R-loops also tended to arise in regions of low-complexity or simple repeats across species. We also found that the repetitive elements associated with R-loop formation differ according to developmental stage. For instance, LINEs and long terminal repeat retrotransposons (LTRs) are more likely to contain R-loops in embryos (fruit fly) and then turn out to be low-complexity and simple repeats in post-developmental S2 cells.


</sec><sec>
<title>Conclusions</title>
Our results indicate that repetitive elements may have species-specific or development-specific regulatory effects on R-loop formation. This work advances our understanding of repetitive elements and R-loop biology.


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リンク情報
DOI
https://doi.org/10.1186/s13100-021-00231-5
URL
http://link.springer.com/content/pdf/10.1186/s13100-021-00231-5.pdf
URL
http://link.springer.com/article/10.1186/s13100-021-00231-5/fulltext.html
ID情報
  • DOI : 10.1186/s13100-021-00231-5
  • eISSN : 1759-8753

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