Isao Nakanishi

Profile Information

Affiliation: Professor, Faculty of Pharmacy, Department of Pharmaceutical Sciences, Kindai University

Degree: 博士（薬学）(大阪大学)

J-GLOBAL ID: 201401086004316207
researchmap Member ID: B000234878

External link: http://kaken.nii.ac.jp/d/r/10362576.ja.html

Research Interests

Research Areas

Research History

Apr, 2008 - Present

Faculty of Pharmacy, Kindai University
Aug, 2003 - Mar, 2008

Kyoto University
Apr, 1985 - Jul, 2003

藤沢薬品工業（株）

Education

Apr, 1983 - Mar, 1985

薬品化学専攻, 薬学研究科, 大阪大学大学院
Apr, 1979 - Mar, 1983

School of Pharmaceutical Sciences, Osaka University

Committee Memberships

Apr, 2009 - Present

SSH運営委員, 奈良県立奈良高等学校
- Present

常任幹事, 日本薬学会構造活性相関部会
Apr, 2015 - Mar, 2020

代議員, 日本薬学会
Mar, 2013 - Mar, 2017

常任幹事, 日本薬学会近畿支部
2015 - 2016

科学研究費補助金審査員
2015 - 2015

日本薬学会学会賞選考委員

Awards

平成17年度日本薬学会･医薬化学部会賞

Papers

Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water

Keiji Nishiwaki, Shiori Nakatani, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi

RSC Medicinal Chemistry, 2024
Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor

Katsuki Takashima, Shinya Nakamura, Maiko Nagayama, Shinsuke Marumoto, Fumihiro Ishikawa, Weijia Xie, Isao Nakanishi, Osamu Muraoka, Toshio Morikawa, Genzoh Tanabe

RSC Advances, 14(7) 4471-4481, 2024
Design, Synthesis and Structure–Activity Relationship Studies of Protein Kinase CK2 Inhibitors Containing a Purine Scaffold

Keiji Nishiwaki, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Shiori Nakatani, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi

Chemical and Pharmaceutical Bulletin, 71(7) 558-565, Jul 1, 2023
Spectral and theoretical analysis of derivatives of 1,2,3,3-tetramethyl-3H-indolium iodide (TMI), a highly selective derivatization reagent of cyanide, and their utility for the analysis of cyanide concentrations in beverages

Keiji Nishiwaki, Yasuhiro Morikawa, Shigeo Suzuki, Kazutaka Shiomi, Isao Nakanishi

Analytical Sciences, Jun 15, 2023
Fragment Molecular Orbital based affinity prediction toward pyruvate dehydrogenase kinases: Insights into the charge transfer in hydrogen bond networks

Tatsuo Akaki, Shinya Nakamura, Keiji Nishiwaki, Isao Nakanishi

Chemical and Pharmaceutical Bulletin, 71(4) 299-306, Feb, 2023 Peer-reviewed
System truncation accelerates binding affinity calculations with the fragment molecular orbital method: A benchmark study

Shinya Nakamura, Tatsuo Akaki, Keiji Nishiwaki, Midori Nakatani, Yuji Kawase, Yuki Takahashi, Isao Nakanishi

Journal of Computational Chemistry, 44(7) 824-831, Nov 29, 2022 Peer-reviewed
Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2α1-selective inhibitors.

Asaka Ikeda, Masato Tsuyuguchi, Daisuke Kitagawa, Masaaki Sawa, Shinya Nakamura, Isao Nakanishi, Takayoshi Kinoshita

Biochemical and biophysical research communications, 630 30-35, Nov 19, 2022
Determination of cyanide in blood by GC–MS using a new high selectivity derivatization reagent 1,2,3,3-tetramethyl-3H-indolium iodide

Yasuhiro Morikawa, Keiji Nishiwaki, Shigeo Suzuki, Kazutaka Shiomi, Isao Nakanishi

Forensic Toxicology, 40(2) 393-399, Jul, 2022
Development of a cost-effective laser diode-induced fluorescence detection instrument for cyanide detection

Yasuhiro Morikawa, Keiji Nishiwaki, Shigeo Suzuki, Mitsuhiro Kinoshita, Isao Nakanishi

Analytical Sciences, 38(2) 437-442, Feb 18, 2022
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.

Tatsuo Akaki, Yuki Bessho, Takashi Ito, Shingo Fujioka, Minoru Ubukata, Genki Mori, Kenji Yamanaka, Takuya Orita, Satoki Doi, Tomoko Iwanaga …

Bioorganic & medicinal chemistry, 44 116283-116283, Aug 15, 2021
Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.

Katsuki Takashima, Mika Sakano, Eri Kinouchi, Shinya Nakamura, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Isao Nakanishi, Toshio Morikawa, Genzoh Tanabe

Bioorganic & medicinal chemistry letters, 33 127751-127751, Feb 1, 2021
Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family

Fumihiro Ishikawa, Aiko Hirano, Yuuto Yoshimori, Kana Nishida, Shinya Nakamura, Katsuki Takashima, Shinsuke Marumoto, Kiyofumi Ninomiya, Isao Nakanishi, Weijia Xie …

RSC Advances, 11(6) 3221-3225, 2021
Activity, Binding, and Modeling Studies of a Reprogrammed Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket.

Fumihiro Ishikawa, Hinano Kitayama, Shinya Nakamura, Katsuki Takashima, Isao Nakanishi, Genzoh Tanabe

Chemical & pharmaceutical bulletin, 69(2) 222-225, 2021
Novel turn-on fluorescent sensor for cyanide ion based on the charge transfer transition of phenothiazine/indolium compounds

Yasuhiro Morikawa, Miku Hirabara, Keiji Nishiwaki, Shigeo Suzuki, Isao Nakanishi

Materials Advances, 2(18) 6104-6111, 2021
A new chemosensor for cyanide in blood based on the Pd complex of 2-(5-bromo-2-pyridylazo)-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol.

Yasuhiro Morikawa, Keiji Nishiwaki, Shigeo Suzuki, Naoyuki Yasaka, Yuto Okada, Isao Nakanishi

The Analyst, 145(23) 7759-7764, Nov 23, 2020
Structural insights for producing CK2α1-specific inhibitors.

Masato Tsuyuguchi, Tetsuko Nakaniwa, Akira Hirasawa, Isao Nakanishi, Takayoshi Kinoshita

Bioorganic & medicinal chemistry letters, 30(2) 126837-126837, Jan 15, 2020 Peer-reviewed
Precise Probing of Residue Roles by NRPS Code Swapping: Mutation, Enzymatic Characterization, Modeling, and Substrate Promiscuity of Aryl Acid Adenylation Domains.

Fumihiro Ishikawa, Maya Nohara, Shinya Nakamura, Isao Nakanishi, Genzoh Tanabe

Biochemistry, 59(4) 351-363, Jan, 2020 Peer-reviewed
A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1.

Tsuyuguchi M, Nakaniwa T, Sawa M, Nakanishi I, Kinoshita T

Acta crystallographica. Section F, Structural biology communications, 75(Pt 7) 515-519, Jul, 2019 Peer-reviewed
An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket.

Ishikawa F, Miyanaga A, Kitayama H, Nakamura S, Nakanishi I, Kudo F, Eguchi T, Tanabe G

Angewandte Chemie (International ed. in English), 58(21) 6906-6910, May, 2019 Peer-reviewed
Structure-Activity Relationships and Docking Studies of Hydroxychavicol and Its Analogs as Xanthine Oxidase Inhibitors.

Nishiwaki K, Ohigashi K, Deguchi T, Murata K, Nakamura S, Matsuda H, Nakanishi I

Chemical & Pharmaceutical Bulletin, 66(7) 741-747, Jul, 2018 Peer-reviewed

Misc.

Structure activity relationship study of ck2 inhibitors with a pyrazole scaffold by nitrogen scan

奥村政輝, 中西伸介, 栗本泰奈, 西脇敬二, 中村真也, 大石真也, 大野浩章, 仲西功

日本薬学会年会要旨集(CD-ROM), 140th, 2020
ヘテロ環アゾ化合物-金属錯体を用いたシアン化物イオンの選択的比色分析

森川泰裕, 八坂直幸, 岡田悠登, 井田博之, 塩見和孝, 西脇敬二, 仲西功, 鈴木茂生, 京都府警科, 近畿大薬

日本分析化学会第68年会要旨集P3137, Sep, 2019
Structure-activity relationship study of CK2 inhibitors with a pyrazole scaffold by nitrogen scan

奥村政輝, 中西伸介, 栗本泰奈, 西脇敬二, 中村真也, 大石真也, 大野浩章, 仲西功

構造活性相関シンポジウム講演要旨集, 47th (CD-ROM), 2019
RAGEを標的とした化学療法誘起末梢神経障害治療薬の探索 in silicoドラッグ・リプロファイリング/リポジショニングからのアプローチ

脇谷航平, 関口富美子, 坪田真帆, 中村真也, 仲西功, 川畑篤史

PAIN RESEARCH, 33(2) 157-157, Jun, 2018
AzelastineはRAGEが関与する化学療法誘起末梢神経障害の発症を抑制する―ドラッグ・リプロファイリング/リポジショニング研究からの知見

脇谷航平, 関口富美子, 坪田真帆, 中村真也, 仲西功, 川畑篤史

日本薬理学会近畿部会プログラム・要旨集, 133rd 44, 2018
プリン骨格を有する新規CK2阻害剤の構造活性相関研究

中川愛理, 吉岡賢司, 露口正人, 木下誉富, 中村真也, 西脇敬二, 仲西功

日本薬学会年会要旨集(CD-ROM), 138th ROMBUNNO.27PA‐pm097, 2018
HydroxychavicolをシードとしたXO阻害化合物の探索研究

西脇敬二, 出口貴浩, 大東可苗, 畑悠佑, 中村真也, 村田和也, 松田秀秋, 仲西功

日本薬学会年会要旨集(CD-ROM), 137th ROMBUNNO.27PA‐am038, 2017
クロスメタセシス反応を利用したスフィンゴシンキナーゼ阻害剤の創製研究

HONDA MAHO, MIYAGAKI JUN, YOSHIMITSU YUJI, IWATA AKIRA, OTSUKI KAZUHIRO, MARUYAMA TOORU, NAKAMURA SHIN'YA, NAKANISHI ISAO, OISHI SHIN'YA, ONO HIROAKI …

日本薬学会年会要旨集(CD-ROM), 135th ROMBUNNO.28S-AM13, 2015
スフィンゴシンキナーゼ阻害活性を有するJaspine B誘導体の構造活性相関研究

HONDA MAHO, MIYAGAKI JUN, YOSHIMITSU YUJI, IWATA AKIRA, OTSUKI KAZUHIRO, MARUYAMA TOORU, NAKAMURA SHIN'YA, NAKANISHI ISAO, OISHI SHIN'YA, ONO HIROAKI …

メディシナルケミストリーシンポジウム講演要旨集, 32nd 119, Nov 7, 2014
サラシア属植物含有α‐グルコシダーゼ阻害活性成分salacinolおよびその類縁体の食後過血糖改善作用

森川敏生, 赤木淳二, 二宮清文, 木内恵里, 田邉元三, 仲西功, 中村真也, 吉川雅之, 村岡修

天然薬物の開発と応用シンポジウム講演要旨集, 20th 75-77, Nov 1, 2014
アーユルベーダ天然薬物“サラシア”由来salacinolをシードとするα‐グルコシダーゼ阻害剤のin silico設計,合成及びin vivo評価

田邉元三, 松田侑也, 筒井望, 森川敏生, 赤木淳二, 二宮清文, 仲西功, 中村真也, 吉川雅之, 村岡修

天然薬物の開発と応用シンポジウム講演要旨集, 20th 72-74, Nov 1, 2014
α‐グルコシダーゼ阻害活性物質salacinolおよびその誘導体の血糖値上昇抑制活性

森川敏生, 木内恵里, 赤木淳二, 二宮清文, 田邉元三, 仲西功, 中村真也, 吉川雅之, 村岡修

日本生薬学会年会講演要旨集, 61st 235-235, Aug 27, 2014
Binding free energy-guided design of Protein kinase CK2 inhibitors and structure-activity relationship analysis

Nakanishi Shinsuke, Okada Hironori, Moriwaki Hirotomo, Nishiwaki Keiji, Nakamura Shinya, Kinoshita Takayoshi, Oishi Shinya, Ohno Hiroaki, Fujii Nobutaka, Nakanishi Isao

Proceedings of the Symposium on Chemoinformatics, 2014 P08-P08, 2014
連続縮環型分子の修飾によるKSP阻害剤の溶解性改善

TAKEUCHI TOMOKI, OISHI SHIN'YA, KANEDA MASATO, ONO HIROAKI, NAKAMURA SHIN'YA, NAKANISHI ISAO, YAMANE MASAYOSHI, SAWADA JUN'ICHI, ASAI AKIRA, FUJII NOBUTAKA

メディシナルケミストリーシンポジウム講演要旨集, 31st 167, Nov 1, 2013
α‐グルコシダーゼ阻害剤,Salacinolの構造活性相関研究―トルイル酸型置換基による3’位疎水化の効果―

田邉元三, 中村真也, 筒井望, 赤木淳二, 森川敏生, 二宮清文, 仲西功, 吉川雅之, 村岡修

メディシナルケミストリーシンポジウム講演要旨集, 31st 112, Nov 1, 2013
α‐グルコシダーゼ阻害剤の酵素阻害活性におけるヒトとラットの種差の計算化学的解析

島田和子, 中村真也, 田邉元三, 村岡修, 仲西功

メディシナルケミストリーシンポジウム講演要旨集, 31st 84, Nov 1, 2013
サラシノールを基点とする新規α‐グルコシダーゼ阻害剤の構造活性相関および創出研究

中村真也, 高平和典, 島田和子, 田邉元三, 村岡修, 仲西功

構造活性相関シンポジウム講演要旨集, 41st 33-34, Oct 21, 2013
金触媒を用いた三成分環化反応によるジヒドロピラゾールの合成とCK2阻害剤開発への応用

ONO HIROAKI, SUZUKI YAMATO, HOU ZENGYE, KURE TATSUHIDE, NAKANISHI ISAO, HIRASAWA AKIRA, OISHI SHIN'YA, FUJII NOBUTAKA

複素環化学討論会講演要旨集, 43rd 353-354, Oct 1, 2013
α‐Glucosidase阻害剤,Salacinolの構造活性相関研究:3’位脂溶性化が活性に及ぼす効果

田邉元三, 中村真也, 筒井望, 赤木淳二, 森川敏生, 二宮清文, 仲西功, 吉川雅之, 村岡修

食品薬学シンポジウム講演要旨集, 5th 178-180, Oct 1, 2013
ヒトとラットにおけるα‐グルコシダーゼ阻害剤アカルボースの酵素阻害活性の種差の検討

島田和子, 中村真也, 高平和典, 田邉元三, 村岡修, 仲西功

日本薬学会年会要旨集(CD-ROM), 133rd(2) ROMBUNNO.29AMB-164S-310, Mar, 2013

Books and Other Publications

大地からの贈り物サラシア

仲西功 (Role: Contributor, PP176-185)

メディカルレビュー社, 2018
くすりをつくる研究者の仕事

仲西功 (Role: Joint author, 第5章)

化学同人, Mar, 2017
わかりやすい物理化学第2版

仲西功 (Role: Joint author)

廣川書店, Sep, 2010
コンピュータで薬を創ろう

仲西功 (Role: Joint author)

ケイディーネオブック, Jun, 2009
インシリコ創薬化学－ゲノム情報から創薬へ－

仲西功 (Role: Joint author)

京都廣川書店, Jul, 2008
新しい薬をどう創るか

仲西功 (Role: Joint author, 第4章)

講談社ブルーバックス, Apr, 2007

Major Presentations

130

基礎薬学科目の知識を臨床へつなぐ新しい学修システム構築の試み?実務実習実施前の学生に対する効果の検証?

大内秀一, 松野純男, 和田哲幸, 伊藤栄次, 前川智弘, 多賀淳, 細見光一, 大鳥徹, 仲西功, 川﨑直人, 岩城正宏

第4回薬学教育学会大会, Aug 24, 2019

Professional Memberships

Research Projects

Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular Basis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Fujii Nobutaka, NAKANISHI Isao, OISHI Shinya
Development of a method to discover high affinity ligands using molecular dynamics simulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

NAKANISHI Isao, KITAURA Kazuo
DEVELOPMENT OF MULTILEVEL FRAGMENT MOLECULAR ORBITAL METHOD

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

KITAURA Kazuo, NAKANISHI Isao
Development of the prediction method of ligand binding affinity in SBDD

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2008

NAKANISHI Isao, KITAURA Kazuo

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Major Presentations

Professional Memberships

Research Projects

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