2019年4月8日
Cells with broken left-right symmetry: roles of intrinsic cell chirality in left-right asymmetric epithelial morphogenesis
Symmetry
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- 巻
- 11
- 号
- 4
- 開始ページ
- 505
- 終了ページ
- 505
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/sym11040505
Chirality is a fundamental feature in biology, from the molecular to the organismal level. An animal has chirality in the left–right asymmetric structure and function of its body. In general, chirality occurring at the molecular and organ/organism scales has been studied separately. However, recently, chirality was found at the cellular level in various species. This “cell chirality” can serve as a link between molecular chirality and that of an organ or animal. Cell chirality is observed in the structure, motility, and cytoplasmic dynamics of cells and the mechanisms of cell chirality formation are beginning to be understood. In all cases studied so far, proteins that interact chirally with F-actin, such as formin and myosin I, play essential roles in cell chirality formation or the switching of a cell’s enantiomorphic state. Thus, the chirality of F-actin may represent the ultimate origin of cell chirality. Links between cell chirality and left–right body asymmetry are also starting to be revealed in various animal species. In this review, the mechanisms of cell chirality formation and its roles in left–right asymmetric development are discussed, with a focus on the fruit fly Drosophila, in which many of the pioneering studies were conducted.
- リンク情報
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- DOI
- https://doi.org/10.3390/sym11040505 本文へのリンクあり
- 共同研究・競争的資金等の研究課題
- 胚発生を制御するシグナルカスケードの要素としての機械的力に関する研究
- URL
- https://www.mdpi.com/2073-8994/11/4/505/htm 本文へのリンクあり
- ID情報
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- DOI : 10.3390/sym11040505
- eISSN : 2073-8994