2020年12月2日
Statistical Validation Verifies That Enantiomorphic States of Chiral Cells Are Determinant Dictating the Left- or Right-Handed Direction of the Hindgut Rotation in Drosophila
Symmetry
- ,
- ,
- 巻
- 12
- 号
- 12
- 開始ページ
- 1991
- 終了ページ
- 1991
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/sym12121991
In the left–right (LR) asymmetric development of invertebrates, cell chirality is crucial. A left- or right-handed cell structure directs morphogenesis with corresponding LR-asymmetry. In Drosophila, cell chirality is thought to drive the LR-asymmetric development of the embryonic hindgut and other organs. This hypothesis is supported only by an apparent concordance between the LR-directionality of cell chirality and hindgut rotation and by computer simulations that connect the two events. In this article, we mathematically evaluated the causal relationship between the chirality of the hindgut epithelial cells and the LR-direction of hindgut rotation. Our logistic model, drawn from several Drosophila genotypes, significantly explained the correlation between the enantiomorphic (sinistral or dextral) state of chiral cells and the LR-directionality of hindgut rotation—even in individual live mutant embryos with stochastically determined cell chirality and randomized hindgut rotation, suggesting that the mechanism by which cell chirality forms is irrelevant to the direction of hindgut rotation. Thus, our analysis showed that cell chirality, which forms before hindgut rotation, is both sufficient and required for the subsequent rotation, validating the hypothesis that cell chirality causally defines the LR-directionality of hindgut rotation.
- リンク情報
-
- DOI
- https://doi.org/10.3390/sym12121991 本文へのリンクあり
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000602462000001&DestApp=WOS_CPL
- 共同研究・競争的資金等の研究課題
- 胚発生を制御するシグナルカスケードの要素としての機械的力に関する研究
- URL
- https://www.mdpi.com/2073-8994/12/12/1991/pdf 本文へのリンクあり
- ID情報
-
- DOI : 10.3390/sym12121991
- eISSN : 2073-8994
- Web of Science ID : WOS:000602462000001