論文

査読有り
2018年

Inference of embryotoxicity of titanium alloy composition metal chemicals as an oral implant body with EST protocol

Nano Biomedicine
  • Koichi Imai
  • ,
  • Tsubasa Shirai
  • ,
  • Hiroki Ishikawa
  • ,
  • Tamaki Nakanishi
  • ,
  • Shosuke Morita

9
1
開始ページ
9
終了ページ
14
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.11344/nano.9.9
出版者・発行元
National Institute of Informatics

The risks of embryotoxicity of pure Ti and Ti alloys used as oral implant materials have not been sufficiently elucidated. The embryonic stem cell test (EST), which allows screening of the fetal teratogenicity of chemical substances, has already been demonstrated to show high predictability by international validation, mainly in Europe. We evaluated the embryotoxicity levels of constituent element ions (Ti, V, Al, Nb, Ta, and Zr) of implants using the EST. As a result, the V ion was found to be associated with some embryotoxicity risks, while the other metal ions showed no embryotoxicity. As previously demonstrated, the V ion shows marked cytotoxicity and carcinogenicity. Therefore, Ti alloys without V ions, such as Ti-6Al-7Nb, should be widely used as implant materials.

リンク情報
DOI
https://doi.org/10.11344/nano.9.9
ID情報
  • DOI : 10.11344/nano.9.9
  • ISSN : 2185-4734
  • ISSN : 1883-5198
  • SCOPUS ID : 85042690351

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