Akihiro Ishizu

J-GLOBAL         Last updated: Oct 2, 2018 at 10:38
 
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Name
Akihiro Ishizu
Affiliation
Hokkaido University
Section
Faculty of Health Sciences

Research Areas

 
 

Published Papers

 
Shida H, Hashimoto N, Kusunoki Y, Hattanda F, Ogawa Y, Hayashi T, Nakazawa D, Masuda S, Tomaru U, Ishizu A
BMC nephrology   19(1) 145   Jun 2018   [Refereed]
Morita S, Nakamaru Y, Nakazawa D, Hattanda F, Shida H, Kusunoki Y, Watanabe K, Masuda S, Takagi D, Suzuki M, Hoshino K, Fukuda A, Tomaru U, Homma A, Ishizu A
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   39(4) e257-e262   Apr 2018   [Refereed]
Mori A, Nishioka Y, Yamada M, Nishibata Y, Masuda S, Tomaru U, Honma N, Moriyama T, Ishizu A
Pathology, research and practice   214(4) 521-526   Apr 2018   [Refereed]
Hasegawa J, Wakai S, Kono M, Imaizumi Y, Masuda S, Ishizu A, Honda K
Internal medicine (Tokyo, Japan)      Apr 2018   [Refereed]
Futamata E, Masuda S, Nishibata Y, Tanaka S, Tomaru U, Ishizu A
Nephron   138(4) 328-330   2018   [Refereed]

Misc

 
【膠原病の病理-今日的視点から-】 膠原病の病態形成メカニズムと最新治療 自己寛容破綻と自己抗体産生のメカニズム
石津 明洋
病理と臨床   36(6) 514-517   Jun 2018
抗ホスファチジルセリン-プロトロンビン複合体抗体による血栓症モデル
山田 真衣, 石津 明洋
リウマチ科   59(5) 542-546   May 2018
「内科医・小児科医・病理医を招いた血管炎シンポジウム」 血管炎診療の病理診断と皮膚病変
石津 明洋
日本皮膚科学会雑誌   128(5) 864-864   May 2018
【MHCクラスIb拘束性T細胞研究の新展開】 【CD1d拘束性T細胞の最近の話題】自己血管内皮細胞反応性type II NKT細胞の血管炎における役割
西岡 佑介, 石津 明洋
医学のあゆみ   265(4) 273-277   Apr 2018
血管炎を自然発症するenv-pXラットから、自己血管内皮細胞に反応し、血管炎を惹起するT細胞クローンVASC-1を単離した。フェノタイプおよびジェノタイプ解析から、VASC-1はtype II NKT細胞であると考えられた。VASC-1は血管内皮細胞上のCD1d分子に提示される自己細胞内抗原sterol carrier protein 2(SCP2)のP518-532を認識し、活性化して炎症性サイトカインを放出する。一方、文献的には自己反応性type II NKT細胞の免疫抑制能が示唆され...
病原性自己抗体と腎・血管障害 ANCAとANCA関連腎炎・血管炎
石津 明洋
日本病理学会会誌   107(1) 219-219   Apr 2018

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Akihiro ISHIZU
Autoreactive vasculitogenic T cell clones were established from env-pX rats, which develop medium to small-sized vasculitis. Identification of the T cell target and the mechanism of vascular injury induced by the T cells might result in the develo...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2006    Investigator(s): Akihiro ISHIZU
We previously showed that thymus plays a critical role in the pathogenesis of necrotizing arteritis occurred in env-pX rats (transgenic rats carrying the LTR-env-pX gene of human T-cell leukemia virus type-1). T-cells autoreactive with the self va...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2004    Investigator(s): 池田 仁, Utano TOMARU
The aims of this project were to investigate the biological role of human endogenous retrovinis-R (HERV-R) in vivo. We have established transgenic rats carrying a full sequence of HERV-R under control of its own long terminal repeat promoter (HERV...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2002 - 2003    Investigator(s): Takashi KYOSHIKI
Virus-host interactions were investigated using rat models for human retrovirus-induced diseases.1.HAM rat disease occurred in HTLV-I-infected rats in a strain-dependent manner. In HAM susceptible rats, expression of the INF-γ gene in the spinal c...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2001    Investigator(s): Hitoshi IKEDA
To investigate the pathogenetic roles of human endogenous retroviruses (HERVs) in autoimmune diseases, we produced transgenicrats carrying an HERV genome and analyzed the transgenic rat as a model. And we tried the cDNA gene cloning for novel HERV...