MINAKO ITO

Profile Information

Affiliation: アレルギー防御学分野, 九州大学生体防御医学研究所

J-GLOBAL ID: 201801021256158766
researchmap Member ID: B000309201

Research Areas

Life sciences / Immunology /

Papers

Reconstruction of Sjögren's syndrome-like sialadenitis by a defined disease specific gut-reactive single TCR and an autoantibody.

Mana Iizuka-Koga, Minako Ito, Noriko Yumoto, Setsuko Mise-Omata, Taeko Hayakawa, Kyoko Komai, Shunsuke Chikuma, Satoru Takahashi, Isao Matsumoto, Takayuki Sumida …

Clinical immunology (Orlando, Fla.), 264 110258-110258, Jul, 2024 Peer-reviewed
Differences in the characteristics and functions of brain and spinal cord regulatory T cells.

Mahiro Watanabe, Ako Matsui, Natsumi Awata, Ayame Nagafuchi, Mio Kawazoe, Yoshihiro Harada, Minako Ito

Journal of neuroinflammation, 21(1) 146-146, Jun 1, 2024 Peer-reviewed
NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment.

Tanakorn Srirat, Taeko Hayakawa, Setsuko Mise-Omata, Kensuke Nakagawara, Makoto Ando, Shigeyuki Shichino, Minako Ito, Akihiko Yoshimura

Cell reports, 43(3) 113898-113898, Mar 26, 2024 Peer-reviewed
SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

Setsuko Mise-Omata, Makoto Ando, Tanakorn Srirat, Kensuke Nakagawara, Taeko Hayakawa, Mana Iizuka-Koga, Hiroshi Nishimasu, Osamu Nureki, Minako Ito, Akihiko Yoshimura

Cell Reports, 42(8) 112940-112940, Aug, 2023 Peer-reviewed
Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease.

Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake …

Inflammation and regeneration, 43(1) 20-20, Mar 15, 2023 Peer-reviewed
Immunity in the brain and surrounding tissues.

Mitsuhiro Kanamori, Minako Ito

Journal of biochemistry, 173(3) 145-151, Mar 7, 2023
T cells in the brain inflammation.

Akihiko Yoshimura, Masaki Ohyagi, Minako Ito

Advances in immunology, 157 29-58, 2023
In Vitro Generation of Brain Regulatory T Cells by Co-culturing With Astrocytes

Shinichi Yamamoto, Ako Matsui, Masaki Ohyagi, Chie Kikutake, Yoshihiro Harada, Mana Iizuka-Koga, Mikita Suyama, Akihiko Yoshimura, Minako Ito

Frontiers in Immunology, 13, Jul 15, 2022 Peer-reviewed
Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory–Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand

Makoto Ando, Taisuke Kondo, Wataru Tomisato, Minako Ito, Shigeyuki Shichino, Tanakorn Srirat, Setsuko Mise-Omata, Kensuke Nakagawara, Akihiko Yoshimura

Cancer Research Communications, 1(1) 41-55, Oct 19, 2021 Peer-reviewed
SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance.

Akihiko Yoshimura, Daisuke Aki, Minako Ito

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 97(6) 277-291, 2021
Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure.

Kyoko Komai, Minako Ito, Seitaro Nomura, Shigeyuki Shichino, Manami Katoh, Shintaro Yamada, Toshiyuki Ko, Mana Iizuka-Koga, Hiroko Nakatsukasa, Akihiko Yoshimura

Frontiers in immunology, 12 763647-763647, 2021
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury.

Ryota Sakai, Minako Ito, Kyoko Komai, Mana Iizuka-Koga, Kazuhiko Matsuo, Takashi Nakayama, Osamu Yoshie, Koichi Amano, Hiroshi Nishimasu, Osamu Nureki …

Cellular & molecular immunology, 18(5) 1249-1261, Sep 11, 2020
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.

Yuki Imura, Makoto Ando, Taisuke Kondo, Minako Ito, Akihiko Yoshimura

JCI insight, 5(14), Jul 23, 2020
Regulatory T Cells: Pathophysiological Roles and Clinical Applications.

Ryota Sakai, Kyoko Komai, Mana Iizuka-Koga, Akihiko Yoshimura, Minako Ito

The Keio journal of medicine, 69(1) 1-15, Mar 25, 2020
Memory T cell, exhaustion, and tumor immunity.

Makoto Ando, Minako Ito, Tanakorn Srirat, Taisuke Kondo, Akihiko Yoshimura

Immunological medicine, 43(1) 1-9, Mar, 2020
Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4+ Treg axis during remission of crescentic glomerulonephritis.

Ryota Sakai, Minako Ito, Keiko Yoshimoto, Shunsuke Chikuma, Takahiko Kurasawa, Tsuneo Kondo, Katsuya Suzuki, Tsutomu Takeuchi, Koichi Amano, Akihiko Yoshimura

Clinical & translational immunology, 9(11) e1203, 2020 Peer-reviewed
Tissue regulatory T cells and neural repair.

Minako Ito, Kyoko Komai, Toshihiro Nakamura, Tanakorn Srirat, Akihiko Yoshimura

International immunology, 31(6) 361-369, May 21, 2019 Peer-reviewed
Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression.

Hiroko Nakatsukasa, Mayumi Oda, Jinghua Yin, Shunsuke Chikuma, Minako Ito, Mana Koga-Iizuka, Kazue Someya, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi …

International immunology, 31(5) 335-347, Apr 26, 2019 Peer-reviewed
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.

Minako Ito, Kyoko Komai, Setsuko Mise-Omata, Mana Iizuka-Koga, Yoshiko Noguchi, Taisuke Kondo, Ryota Sakai, Kazuhiko Matsuo, Takashi Nakayama, Osamu Yoshie …

Nature, 565(7738) 246-250, Jan, 2019 Peer-reviewed
Development and Functional Modulation of Regulatory T Cells by Transcription Factors and Epigenetics.

Minako Ito, Mana Iizuka-Koga, Makoto Ando, Akihiko Yoshimura

Cornea, 37 Suppl 1 S42-S49, Nov, 2018 Peer-reviewed

Misc.

【間質リテラシーと疾患】脳梗塞と間質に存在する細胞の役割

松井亜子, 伊藤美菜子

炎症と免疫, 31(1) 12-17, Dec, 2022
【脳をしなやかに制御するミクログリアと脳内免疫系見えてきた起源と多様性、創薬標的の可能性】ミクログリアと脳内T細胞・B細胞

伊藤美菜子

実験医学, 40(18) 2967-2971, Nov, 2022
医学用語解説組織Treg

伊藤美菜子

炎症と免疫, 30(5) 457-461, Aug, 2022
本年の動向脳梗塞後の制御性T細胞による組織修復機構

伊藤美菜子

Annual Review神経, 2022 67-73, May, 2022
【シン・マクロファージあらゆる疾患を制御する機能的多様性】(第2章)病気とマクロファージの多様性を知る14の方法脳梗塞後の炎症とマクロファージ

吉村昭彦, 七田崇, 伊藤美菜子

実験医学, 40(5) 774-780, Mar, 2022
【神経免疫メカニズムと疾患神経系と免疫系を結ぶ分子機構の解明からバイオマーカー・治療標的の探索まで】(第1章)神経免疫のメカニズム神経炎症の誘導と制御(リンパ球) 制御性T細胞による中枢神経炎症制御

伊藤美菜子, 山本伸一, 大谷木正貴, 吉村昭彦

実験医学, 39(15) 2342-2347, Sep, 2021
【IL-33バイオロジー】制御性T細胞とIL-33

伊藤美菜子, 大谷木正貴, 山本伸一, 吉村昭彦

臨床免疫・アレルギー科, 74(5) 470-476, Nov, 2020
【免疫リプログラミングと細胞デザイン】免疫寛容誘導による免疫リプログラミング組織Tregにおける免疫リプログラミング

伊藤美菜子

医学のあゆみ, 275(1) 108-112, Oct, 2020
脳内制御性T細胞による脳梗塞慢性期の神経修復

伊藤美菜子, 吉村昭彦

感染・炎症・免疫, 50(2) 84-93, Oct, 2020
【マクロファージの功罪-疾患病態誘導と制御におけるマクロファージの役割】脳・神経脳梗塞後の神経症状回復を促す脳特異的制御性T細胞

伊藤美菜子

医学のあゆみ, 273(10) 980-984, Jun, 2020
【Treg】組織Tregと組織修復

伊藤美菜子, 山本伸一, 吉村昭彦

臨床免疫・アレルギー科, 72(6) 575-582, Dec, 2019
【最も修復しにくい臓器中枢神経を再生せよ!炎症・グリア・臓器の連環が織りなすメカニズムから機能回復に挑む】脳損傷の修復における自然免疫と獲得免疫

伊藤美菜子, 駒井恭子, 吉村昭彦

実験医学, 37(13) 2104-2111, Aug, 2019
【死細胞由来分子が巻き起こす炎症病態】脳梗塞後の無菌性炎症における自然免疫と獲得免疫

伊藤美菜子, 中村敏弘, Srirat Tanakorn, 吉村昭彦

炎症と免疫, 27(4) 266-272, Jun, 2019
【制御性T細胞研究の現在】基礎分化組織特異的制御性T細胞

伊藤美菜子, 中村敏弘, Sriart Tanakorn, 吉村昭彦

医学のあゆみ, 268(13) 1049-1056, Mar, 2019
脳梗塞後の炎症の収束機構と治療への応用

伊藤美菜子, 七田崇, 吉村昭彦

感染・炎症・免疫, 47(4) 268-277, Jan, 2018
【腸内フローラと神経・精神疾患】腸内フローラと神経・精神疾患脳虚血後炎症

伊藤美菜子, 七田崇, 吉村昭彦

Clinical Neuroscience, 35(11) 1327-1329, Nov, 2017
INDUCTION AND RESOLUTION OF POST-ISCHEMIC INFLAMMATION BY DAMPS

T. Shichita, M. Ito, A. Yoshimura

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36 285-285, Jun, 2016
BRUTON'S TYROSINE KINASE (BTK) IS AN ESSENTIAL COMPONENT FOR NLRP3 INFLAMMASOME ACTIVATION AND A POTENTIAL THERAPEUTIC TARGET FOR INFLAMMATION AFTER ISCHEMIC BRAIN INJURY

M. Ito, T. Shichita, A. Yoshimura, R. Morita

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36 459-459, Jun, 2016
【神経・免疫のクロストーク】脳虚血と炎症

伊藤美菜子, 七田崇, 森田林平, 吉村昭彦

最新医学, 71(2) 243-249, Feb, 2016
認知症、炎症と血管障害リスク脳虚血後炎症

七田崇, 伊藤美菜子, 吉村昭彦

脳循環代謝, 26(2) 135-139, Aug, 2015

Research Projects

Brain inflammation and repair mechanism by adaptive immunity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2026
Establishment of interstitial literacy based on complex systems crosstalk

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, May, 2022 - Mar, 2025
脳Treg・ミクログリアの相互作用による脳組織修復促進メカニズムの解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

伊藤美菜子
脳組織特異的制御性T細胞誘導メカニズムの解明

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2023

伊藤美菜子
神経精神疾患発症における免疫応答によるシンギュラリティの解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2021 - Mar, 2023

伊藤美菜子
The recognition of neo-self by regulatory T cells in brain inflammation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021
The significance of regulatory T cells in the brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021

Ito Minako
Elucidation of the significance of regulatory T cells in the chronic phase of cerebral infarction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

ITO MINAKO

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