論文

査読有り 国際誌
2014年

Detection of residual cognitive function through non-spontaneous eye movement in a patient with advanced frontotemporal dementia.

Frontiers in neuroscience
  • Akira Midorikawa
  • ,
  • Chihiro Itoi
  • ,
  • Mitsuru Kawamura

8
開始ページ
334
終了ページ
334
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fnins.2014.00334

As dementia progresses, cognitive functions decline in patients, and caregivers and other support staff gradually lose the means to communicate with them. However, some caregivers believe that patients can still recognize their surroundings even when they show akinesis with mutism. In this study, we observed eye movements (preferential-looking paradigm) to detect the presence of residual cognitive functions in a patient with severe frontotemporal dementia (FTD). The subject was a 76-year-old female. At the time of observation, she had lost all spontaneous activities. Magnetic resonance imaging (MRI) imaging showed dense atrophy of the bilateral frontotemporal lobe, but the parieto-occipital lobe was preserved. A preferential-looking paradigm was used in the experiment, whereby two different faces (learned and non-learned) were simultaneously presented to the patient on a TV monitor. As a result, we found no significant differences in looking time between the two faces. However, when the saccade timing to the presented faces was examined, a much longer latency was observed for the right than the left side of the target faces. Even though the patient had lost capacity for spontaneous activity due to severe FTD, we were able to observe partial residual cognitive ability using the eye-movement paradigm.

リンク情報
DOI
https://doi.org/10.3389/fnins.2014.00334
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25386114
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208403
ID情報
  • DOI : 10.3389/fnins.2014.00334
  • PubMed ID : 25386114
  • PubMed Central 記事ID : PMC4208403

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