Ikuo Tsunoda

J-GLOBAL         Last updated: Nov 2, 2018 at 11:29
 
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Name
Ikuo Tsunoda
Nickname
Ikuo
E-mail
itsunodahotmail.com
URL
http://www.med.kindai.ac.jp/microbio/
Affiliation
Kindai University
Section
Microbiology
Job title
Professor
Degree
MD(Tohoku University School of Medicine), PhD(Tohoku University)
Research funding number
00261529
ORCID ID
0000-0003-1798-714X

Profile

Our research is aimed at elucidating the pathogenesis of autoimmune disorders and virus infections in the central nervous system (CNS), using autoimmune and viral models for multiple sclerosis (MS): experimental autoimmune (allergic) encephalomyelitis (EAE) and Theiler’s murine encephalomyelitis virus (TMEV) infection in mice. We have studied both host immune responses and pathogens (viruses), in vivo and in vitro, using immunological, virological, and neuropathological methods. Although axonal degeneration has been described in MS, it was believed to occur only secondarily to demyelination. We have demonstrated that 1) axonal damage precedes demyelination in TMEV infection (Inside-Out model) and 2) axonal degeneration plays a detrimental role in EAE, while it plays a beneficial role in TMEV infection, and 3) axonal degeneration recruits inflammatory cells to sites of Wallerian degeneration. We hypothesize that axonal degeneration can be a self-destructive defense mechanism that limits the spread of neurotropic viruses. We have also conducted studies on the roles of autoreactive CD8+ cytotoxic T cells (CTL) and natural killer T (NKT) cells in TMEV infection and established a mouse model for primary progressive (PP)- and secondary progressive (SP)-MS. This established model system will be used to elucidate the roles for cytokines, natural antibody, and apoptosis in lymphoid organs in deciphering how these factors interact and contribute to switching a disease course of autoimmune diseases from relapsing-remitting to a progressive type. Recently, we have established a viral model for myocarditis in mice.

Research Areas

 
 

Academic & Professional Experience

 
Apr 2016
 - 
Today
Professor and Chair, Department of Microbiology, Kindai University Faculty of Medicine
 
Jul 2015
 - 
Mar 2016
Associate Professor, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center
 
Jul 2015
 - 
Mar 2016
Adjunct Associate Professor, Department of Neurology, Louisiana State University Health Sciences Center
 
Jul 2009
 - 
Jun 2015
Assistant Professor, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center
 
Jan 2008
 - 
Jun 2009
Adjunct Assistant Professor, Department of Neurology, University of Utah School of Medicine
 

Education

 
Apr 1990
 - 
Mar 1994
Neuropathology, Graduate School of Medicine, Tohoku University
 
Apr 1984
 - 
Mar 1990
School of Medicine, Tohoku University
 

Committee Memberships

 
2015
 - 
Today
National Institutes of Health (NIH), Centers of Biomedical Research Excellence (COBRE)  Reviewer, COBRE Small Grants Program P30GM114737. University of Hawaii
 
2015
 - 
2016
Swiss Multiple Sclerosis Society  Reviewer, Project Grant
 
2016
   
 
Florida Department of Health  Reviewer, Zika Research Grant Initiative
 
2014
   
 
Multiple Sclerosis Society, UK  Reviewer, Project Grant
 
2010
   
 
The National Multiple Sclerosis Society  Ad Hoc Reviewer NMSS, Pilot Research Award
 

Awards & Honors

 
2008
Junior Faculty Travel Grant Award, American Association of Immunologists (AAI)
 
2006
Travel Award, The Consortium of Multiple Sclerosis Centers (CMSC)
 
1996
certification number 0-449-653-5, ECFMG Certification, The Educational Commission for Foreign Medical Graduates
 

Published Papers

 
Park AM, Tsunoda I
BioTechniques      Aug 2018   [Refereed]
Smith HK, Omura S, Vital SA, Becker F, Senchenkova EY, Kaur G, Tsunoda I, Peirce SM, Gavins FNE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   32(5) fj201700746R-2394   Jan 2018   [Refereed]
Park AM, Tsunoda I, Yoshie O
The Journal of biological chemistry      Aug 2018   [Refereed]
Omura S, Sato F, Martinez NE, Range T, Ekshyyan L, Minagar A, Alexander JS, Tsunoda I
Archives of virology   163(5) 1279-1284   Jan 2018   [Refereed]
Kanai K, Park AM, Watanabe A, Arikawa T, Yasui T, Yoshida H, Tsunoda I, Yoshie O
Journal of immunology (Baltimore, Md. : 1950)   200(8) 2703-2713   Apr 2018   [Refereed]
Choi J, Cooper ML, Staser K, Ashami K, Vij KR, Wang B, Marsala L, Niswonger J, Ritchey J, Alahmari B, Achilefu S, Tsunoda I, Schroeder MA, DiPersio JF
Leukemia      Apr 2018   [Refereed]
Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, Hirata T, Tsunoda I, Nakayama T, Yoshie O
Journal of immunology (Baltimore, Md. : 1950)   200(2) 800-809   Jan 2018   [Refereed]
Sato F, Kawai E, Martinez NE, Omura S, Park AM, Takahashi S, Yoh K, Tsunoda I
Scientific reports   7(1) 10496   Sep 2017   [Refereed]
Park AM, Omura S, Fujita M, Sato F, Tsunoda I
Clinical & experimental neuroimmunology   8(3) 215-232   Aug 2017   [Refereed][Invited]
Kyosuke Kanai, Ah-Mee Park, Hiroki Yoshida, Ikuo Tsunoda, Osamu Yoshie
The Journal of Immunology   1600506   Jan 2017   [Refereed]
Neuropathogenesis of Zika virus infection: Potential roles of antibody-mediated pathology
Tsunoda I, Omura S, Sato F, Kusunoki S, Fujita M, Park A-M, Hasanovic F, Yanagihara R, and Nagata S
Acta Med Kindai Univ   41(2) 37-52   Dec 2016   [Refereed][Invited]
Yun JW, Xiao A, Tsunoda I, Minagar A, Alexander JS
Pathophysiology : the official journal of the International Society for Pathophysiology   23(4) 265-274   Dec 2016   [Refereed]
Ikuo Tsunoda, Fumitaka Sato, Seiichi Omura, Mitsugu Fujita, Namie Sakiyama, Ah-Mee Park
Clinical and Experimental Neuroimmunology   7(4) 345   Nov 2016   [Refereed][Invited]
Becker F, Kurmaeva E, Gavins FN, Stevenson EV, Navratil AR, Jin L, Tsunoda I, Orr AW, Alexander JS, Ostanin DV
Inflammatory bowel diseases      Mar 2016   [Refereed]
Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, Tsunoda I
Brain, behavior, and immunity   43 86-97   Jan 2015   [Refereed]
Sato F, Martinez NE, Stewart EC, Omura S, Alexander JS, Tsunoda I
BMC neurology   15 219   Oct 2015   [Refereed]
Kawai E, Sato F, Omura S, Martinez NE, Reddy PC, Taniguchi M, Tsunoda I
Journal of neuroimmunology   278 174-184   Jan 2015   [Refereed]
J.S. Alexander, R. Chervenak, B. Weinstock-Guttman, I. Tsunoda, M. Ramanathan, N. Martinez, S. Omura, F. Sato, G.V. Chaitanya, A. Minagar, J. McGee, M.H. Jennings, C. Monceaux, F. Becker, U. Cvek, M. Trutschl, R. Zivadinov
Journal of the Neurological Sciences   355(1-2) 84   Aug 2015   [Refereed]

Misc

 
佐藤文孝, 川合英一郎, マルチネス ニコラス, 尾村誠一, 藤田貢, 朴雅美, 崎山奈美江, 高橋智, 楊景堯, 角田郁生
Neuroimmunology   22(1) 112   2017
角田郁生
近畿大学医学雑誌   41(3-4) 7A‐9A   Dec 2016
金井亨輔, 朴雅美, 角田郁生, 吉田裕樹, 義江修
日本インターフェロン・サイトカイン学会学術集会抄録集   81st 88   Apr 2016
尾村誠一, 尾村誠一, 佐藤文孝, 佐藤文孝, ALEXANDER J. Steven, KILGORE Phillip C. S. R., CVEK Urska, TRUTSCHL Marjan, 角田郁生, 角田郁生
Neuroimmunology   21(1) 120   2016
朴雅美, 角田郁生
日本分子生物学会年会プログラム・要旨集(Web)   39th ROMBUNNO.3P‐0357 (WEB ONLY)   2016

Books etc

 
Neuroinflammation (2nd edition)
Ikuo Tsunoda
Elsevier   2017   
Multiple Sclerosis: A Mechanistic View
Ikuo Tsunoda (Part:Contributor, Role of CD4+ T lymphocytes in pathophysiology of multiple sclerosis.)
2016   
Neuroinflammation, 1st edition
Ikuo Tsunoda (Part:Contributor, Animal models for multiple sclerosis.)
Elsevier   2011   
Encyclopedia of Neuroscience
Ikuo Tsunoda (Part:Contributor, Central nervous system degeneration caused by autoimmune cytotoxic CD8+ T cell clones and hybridomas.)
Springer-Verlag GmbH Berlin Heidelberg   2009   
Persistent Viral Infections.
Ikuo Tsunoda (Part:Contributor, Theiler’s murine encephalomyelitis virus (TMEV).)
John Wiley & Sons, Ltd   1999   
Experimental Models of Multiple Sclerosis
Ikuo Tsunoda (Part:Contributor, TMEV and neuroantigens: Myelin genes and proteins, molecular mimicry, epitope spreading and autoantibody-mediated remyelination.)
Springer   2005   

Conference Activities & Talks

 
New diagnostic algorithm of HIV/AIDS in Nepal
Khadka S, and Tsunoda I
4th Dianken Microbiology Colloquium   31 Oct 2018   
Theiler’s virus-induced myocarditis model with acute viral replication, subacute T cell infiltration and chronic fibrosis in the heart
105. Sato F, Omura S, Martinez NE, Cliburn EA, Acharya MM, Reddy PC, Alexander JS, and Tsunoda I
The 66th Annual Meeting of the Japanese Society for Virology   28 Oct 2018   
A Severe Infectious Mononucleosis-Like Disease in IL-27-Deficient Mice Infected with Murine γ-Herpesvirus 68
104. Kanai K, Park A-M, Tsunoda I, and Yoshie O
he 66th Annual Meeting of the Japanese Society for Virology   28 Oct 2018   
Bioinformatics analyses identified phase-specific heart biomarkers and blood surrogate markers for a mouse model of viral myocarditis.
105. Omura S, Sato F, Park A-M, Fujita M, Alexander JS, Kilgore PCSR, Cvek U, Tsunoda I
Research and Industry Day (RAID) 2018 Conference   26 Oct 2018   
Exploratory factor analysis determines latent factors associated with distinct sets of anti-glycolipid antibodies in Guillain-Barré syndrome
Omura S, Shimizu K, Kuwahara M, Morikawa M, Fujita M, Park A-M, Sato F, Pedio E, Kusunoki S, Tsunoda I.
The 30th Annual Meeting of the Japanese Society for Neuroimmunology   20 Sep 2018   
Distinct sets of anti-glycolipid antibodies are associated with latent factors in Guillain-Barré syndrome by exploratory factor analysis. [Invited]
103. Omura S, Shimizu K, Kuwahara M, Morikawa M, Fujita M, Park A-M, Sato F, Kusunoki S, and Tsunoda I
14th International Congress of Neuroimmunology (ISNI 2018)   27 Aug 2018   
Potential prebiotic β-glucan curdlan differently alters viral versus autoimmune models of MS. [Invited]
102. Sato F, Martinez NE, Omura S, Park A-M, Fujita M, Minagar A, Alexander JS, and Tsunoda I
The 8th Sendai Conference 2018   14 Jul 2018   
Neurotropic virus infection downregulates lymphatic molecules, suppressing lymphocyte exit from the central nervous system.
Tsunoda I, Omura S, Sato F, Park A-M, Fujita M, Sakiyama N, Minagar A, Phillip CSR Kilgore PCSR, Cvek U and Alexander JS
The 12th China-Japan International Conference of Virology   17 May 2018   
Bioinformatics analyses identified phase-specific heart biomarkers and blood surrogate markers for a mouse model of viral myocarditis.
101. Omura S, Sato F, Park A-M, Fujita M, Alexander JS, Kilgore PCSR, Cvek U, Tsunoda I
Louisiana Biomedical Research Network (LBRN) 16th Annual Meeting   10 Jan 2018   
Bioinformatics analyses identified phase-specific heart biomarkers and blood surrogate markers for a mouse model of viral myocarditis
Omura S, Sato F, Park A-M, Fujita M, Alexander JS, Kilgore CSR, Cvek U, and Tsunoda I
The 65th Annual Meeting of the Japanese Society for Virology   24 Oct 2017   
Factor Analysis Associated Anti-Glycolipid Antibodies with Clinical Data in Guillain-Barré Syndrome
Omura S, Shimizu K, Morikawa M, Kuwahara M, Kawamura T, Mori T, Kusunoki S, and Tsunoda I
Informatics in Biology, Medicine and Pharmacology (IIBMP2017)   27 Sep 2017   
Bioinformatics analysis determined the CNS and peripheral lymphoid surrogate biomarker candidates between two distinct EAE models for progressive multiple sclerosis
Omura S, Sato F, Martinez NE, Park A-M, Cvek U, Minagar A, Alexander JS, and Tsunoda I
XXIII World Congress of Neurology   16 Sep 2017   
Viral infection activates myelin-specific T cells, triggering MS-like CNS inflammatory demyelination
Sato F, Omura S, Park A-M, Fujita M, Stokes KY, and Tsunoda I
XXIII World Congress of Neurology   16 Sep 2017   
An RNA virus triggers inflammatory demyelination in the central nervous system by activating anti-myelin autoimmune T cells [Invited]
Sato F, Legaux KN, Creason TG, Omura S, Park A-M, Fujita M, Stokes KY and Tsunoda I
7th Sendai Conference 2017   8 Jul 2017   
Computational analysis determined the homogeneities and heterogeneieties between two distinct EAE models for progressive multiple sclerosis. [Invited]
Omura S, Sato F, Martinez NE, Park A-M, Fujita M, Kilgore PCSR, Cvek, U, Trutschl M, Minagar A, Alexander JS, and, Tsunoda I
7th Sendai Conference 2017   8 Jul 2017   
Multiple sclerosis as a vascular disease. [Invited]
Minagar A, Tsunoda I, and Alexander JS.
The 6th Annual International Society for Neurovascular Disease (ISNVD) Scientific Meeting   29 Apr 2016   
Upregulation of lymphatic markers and vascular adhesion molecules in CNS RNAseq transcriptome of a viral model for multiple sclerosis. [Invited]
Omura S, Sato F, Alexander JS, Kilgore PCSR, Cvek U, Trutschl M, and Tsunoda I.
The 6th Annual International Society for Neurovascular Disease (ISNVD) Scientific Meeting   29 Apr 2016   
Monocytes/macrophages play a contributing role in lymphangiogenesis independent of their role in intestinal inflammation.
Becker F, Vowinkel T, Rijcken E, Tsunoda I, Ostanin DV and Alexander JS.
133. Kongress Deutsche Gesellschaft für Chirurgie   26 Apr 2016   
Brain endothelial cells segregate lymphatic-venous biomarkers into microparticles following inflammatory cytokine stimulation.
Yun JW, Minagar A, Tsunoda I, and Alexander JS.
Experimental Biology 2016, April 2-6, 2016, San Diego, California   2 Apr 2016   
Contributions of monocytes to gut inflammation in acute and chronic colitis models. [Invited]
Becker F, Gavins FN, Vowinkel T, Tsunoda I, Rijcken E, Ostanin DV, and Alexander JS.
11th Congress of European Crohn’s and Colitis Organization (ECCO)   16 Mar 2016   

Teaching Experience

 
 

Research Grants & Projects

 
Animal models for multiple sclerosis
Louisiana State University Health Sciences Center (LSUHSC): Neurology Research Grant
Project Year: 2015 - 2016    Investigator(s): Ikuo Tsunoda
Role of Th17/Treg Immunoregulatory Axis in a Viral Model for Multiple Sclerosis
NIH/National Institute of General Medical Sciences (NIGMS): Centers of Biomedical Research Excellence (COBRE) III Pilot Grant
Project Year: 2014 - 2016    Investigator(s): Ikuo Tsunoda
Neurotropic viral model
Louisiana State University Health Sciences Center (LSUHSC): Research Development Funds
Project Year: 2013 - 2014    Investigator(s): Ikuo Tsunoda
Neuroprotective Role of Glatiramer Acetate in a Viral Model for Multiple Sclerosis
TEVA Neuroscience: Investigator-Initiated Studies Program
Project Year: 2012 - 2014    Investigator(s): Ikuo Tsunoda
Regulatory Role of Natural Killer T cells in Cardiovirus-induced Myocarditis
Malcolm Feist Cardiovascular Foundation: Malcolm Feist Cardiovascular Research Fellowship
Project Year: 2011 - 2014    Investigator(s): Fumitaka Sato, Ikuo Tsunoda
Systems Biology Approach for Molecular Mechanisms in Viral Myocarditis
Malcolm Feist Cardiovascular Foundation: Malcolm Feist Cardiovascular Research Fellowship
Project Year: 2011 - 2014    Investigator(s): Seiichi Omura, Ikuo Tsunoda
Th Cells in Theiler’s Virus Persistence and Pathology
NIH/National Center for Research Resources (NCRR) and National Institute of General Medical Sciences (NINGS): Centers of Biomedical Research Excellence (COBRE) II
Project Year: 2010 - 2014    Investigator(s): Ikuo Tsunoda
NeuroVirology and Neuroimmunology Animal Models
Louisiana State University Health Sciences Center (LSIHSC): Research Council Seed Package
Project Year: 2009 - 2012    Investigator(s): Ikuo Tsunoda
Axonal Degeneration can Trigger Demyelinating Disease
National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS): R21
Project Year: 2008 - 2011    Investigator(s): Ikuo Tsunoda
Treatment of Animal Models for MS with Resveratrol, a Natural Compound in Red Wine
National Multiple Sclerosis Society (NMSS): Pilot Research Award
Project Year: 2008 - 2009    Investigator(s): Ikuo Tsunoda
Does Axonal Injury Recruit Inflammatory Cells to the Site of Axonal Degeneration, Targeting Demyelinating Lesions? Inside-Out Model for Multiple Sclerosis.
University of Utah: The Funding Incentive Seed Grant
Project Year: 2006 - 2008    Investigator(s): Ikuo Tsunoda
Immunologic Factors In Progressive Autoimmune Disease
National Institute of Health (NIH) / National Institute of Neurological Disorders and Stroke (NINDS): R01
Project Year: Jul 2002 - Jun 2006    Investigator(s): Robert S. Fujinami, Ikuo Tsunoda
Multiple sclerosis (MS) can be divided into four clinical forms: relapsing-remitting (RR), primary progressive (PP), secondary progressive (SP) and progressive relapsing (PR). The pathogenesis of the progressive forms of MS remains unclear, partly...
Lesion development from inside (axon) to outside (myelin): Inside-Out models
National Multiple Sclerosis Society (NMSS): Pilot Research Award
Project Year: 2005 - 2005    Investigator(s): Ikuo Tsunoda
Viral and Cellular Deteminants Involved in CNS Disease
National Institute of Health (NIH) / National Institute of Neurological Disorders and Stroke (NINDS): R01
Project Year: 1995 - 2005    Investigator(s): Robert S. Fujinami, Ikuo Tsunoda
Theiler's murine encephalomyelitis virus (TMBV) infection of mice is a relevant animal model for the human demyelinating disease multiple sclerosis (MS). TMEV belongs to the Picornaviridae family and are in the Cardiovirus genus. These viruses are...
Viruses and Autoimmunity ot the Central Nervous System
National Institute of Health (NIH) / National Institute of Allergy and Infectious Diseases (NIAID): R01
Project Year: 2004       Investigator(s): Robert S. Fujinami, Ikuo Tsunoda
Most evidence suggests that multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). It is the most common human demyelinating disease. Immune mediated events are involved in the etiology and pathogenesis. Therefore, m...

Social Contribution

 
Walk MS Shreveport Team Leader
[Organizing Member]  National Multiple Sclerosis Society (NMSS), Louisiana  Walk MS Shreveport  2011 - 2015