論文

査読有り
2012年9月

How Vitamin D Works on Bone

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
  • Tomohiko Yoshida
  • ,
  • Paula H. Stern

41
3
開始ページ
557
終了ページ
+
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ecl.2012.04.003
出版者・発行元
W B SAUNDERS CO-ELSEVIER INC

Vitamin D is important for the normal development and maintenance of bone. The elucidation of the vitamin D activation pathway and the cloning of the vitamin D receptor have advanced our understanding of the actions of vitamin D on bone. The preponderance of evidence indicates that 1,25(OH)2D3 enhances bone mineralization through its effects to promote calcium and phosphate absorption. Although 1,25(OH)2D3 stimulates bone resorption in vitro, treatment in vivo can prevent bone loss and fracture through several potential mechanisms. The development of vitamin D analogues has provided new therapeutic options for increasing bone mineral density and reducing fractures.

Web of Science ® 被引用回数 : 25

リンク情報
DOI
https://doi.org/10.1016/j.ecl.2012.04.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22877429
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000308380100007&DestApp=WOS_CPL

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