論文

査読有り
2006年10月

Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3M-E1

FEBS LETTERS
  • Tomohiko Yoshida
  • ,
  • Mie Asanuma
  • ,
  • Laura Grossmann
  • ,
  • Masami Fuse
  • ,
  • Takahisa Shibata
  • ,
  • Taeko Yonekawa
  • ,
  • Tomoaki Tanaka
  • ,
  • Koichi Ueno
  • ,
  • Tatsuji Yasuda
  • ,
  • Yasushi Saito
  • ,
  • Ichiro Tatsuno

580
22
開始ページ
5203
終了ページ
5207
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.febslet.2006.08.060
出版者・発行元
ELSEVIER SCIENCE BV

Isoprenylation of geranylgeranyl-pyrophosphate (GGPP) is critical for activation of small GTPases. We examined the roles of GGPP synthase (GGPPS) during the differentiation induced by the cell-to-cell contact in osteoblastic cell line MC3T3-E1 cells. We found that (1) both mRNA and protein expression of GGPPS was reduced with decrement of its activity during the differentiation, (2) GGOH, which is converted to GGPP in the cells, inhibited differentiation. These results suggest that the decrement of GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 17

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2006.08.060
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16978613
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000241044400014&DestApp=WOS_CPL

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