2022年8月20日
Designing isolation guidelines for COVID-19 patients with rapid antigen tests
Nature Communications
- 巻
- 13
- 号
- 1
- 開始ページ
- 4910
- 終了ページ
- 4910
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-022-32663-9
Appropriate isolation guidelines for COVID-19 patients are warranted. Currently, isolating for fixed time is adopted in most countries. However, given the variability in viral dynamics between patients, some patients may no longer be infectious by the end of isolation, whereas others may still be infectious. Utilizing viral test results to determine isolation length would minimize both the risk of prematurely ending isolation of infectious patients and the unnecessary individual burden of redundant isolation of noninfectious patients. In this study, we develop a data-driven computational framework to compute the population-level risk and the burden of different isolation guidelines with rapid antigen tests (i.e., lateral flow tests). Here, we show that when the detection limit is higher than the infectiousness threshold values, additional consecutive negative results are needed to ascertain infectiousness status. Further, rapid antigen tests should be designed to have lower detection limits than infectiousness threshold values to minimize the length of prolonged isolation.
- リンク情報
- ID情報
-
- DOI : 10.1038/s41467-022-32663-9
- ORCIDのPut Code : 117528550
- PubMed ID : 35987759
- PubMed Central 記事ID : PMC9392070