2016年5月
Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins
NEURON
- 巻
- 90
- 号
- 4
- 開始ページ
- 752
- 終了ページ
- 767
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2016.04.001
- 出版者・発行元
- CELL PRESS
Postsynaptic kainate-type glutamate receptors (KARs) regulate synaptic network activity through their slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in the hippocampus. Nevertheless, how KARs cluster and function at these synapses has been unclear. Here, we show that C1q-like proteins C1ql2 and C1ql3, produced by MFs, serve as extracellular organizers to recruit functional postsynaptic KAR complexes to the CA3 pyramidal neurons. C1ql2 and C1ql3 specifically bound the amino-terminal domains of postsynaptic GluK2 and GluK4 KAR subunits and the presynaptic neurexin 3 containing a specific sequence in vitro. In C1ql2/3 double-null mice, CA3 synaptic responses lost the slow, KAR-mediated components. Furthermore, despite induction of MF sprouting in a temporal lobe epilepsy model, KARs were not recruited to postsynaptic sites in C1ql2/3 double-null mice, leading to reduced recurrent circuit activities. C1q family proteins, broadly expressed, are likely to modulate KAR function throughout the brain and represent promising antiepileptic targets.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neuron.2016.04.001
- ISSN : 0896-6273
- eISSN : 1097-4199
- PubMed ID : 27133466
- Web of Science ID : WOS:000376255600010