論文

国際誌
2015年9月

The Glasgow Prognostic Score Determined During Concurrent Chemoradiotherapy Is an Independent Predictor of Survival for Cervical Cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • Takeshi Nishida
  • ,
  • Keiichiro Nakamura
  • ,
  • Junko Haraga
  • ,
  • Chikako Ogawa
  • ,
  • Tomoyuki Kusumoto
  • ,
  • Noriko Seki
  • ,
  • Hisashi Masuyama
  • ,
  • Norihisa Katayama
  • ,
  • Susumu Kanazawa
  • ,
  • Yuji Hiramatsu

25
7
開始ページ
1306
終了ページ
14
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/IGC.0000000000000485

OBJECTIVE: The Glasgow prognostic score (GPS) determined at pretreatment is important in the prediction of prognosis in various cancers. We investigated if the GPS used both at pretreatment and during concurrent chemoradiotherapy (CCRT) could predict the prognosis of patients with cervical cancer. METHODS: We collected GPS and clinicopathological data from the medical records of 91 patients who underwent CCRT for cervical cancer; their GPSs at pretreatment and during CCRT were retrospectively analyzed for correlations with recurrence and survival. Statistical analyses were performed using the Mann-Whitney U test. Disease-free survival (DFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Cox's proportional hazard regression was used for univariate and multivariate analyses. RESULTS: The median follow-up for all patients who were alive at the time of last follow-up was 38.0 months (range, 1-108 months). The DFS and OS rates of patients with a high GPS during CCRT (GPS 1 + 2; 55 patients; 60.4%) were significantly shorter than those for patients with a low GPS (GPS 0; 36 patients; 39.6%) (DFS, P < 0.001; OS, P < 0.001). Furthermore, multivariate analyses showed that high GPS during CCRT was an independent prognostic factor of survival for OS (P = 0.008). CONCLUSIONS: During CCRT, a high GPS was revealed to be an important predictor of survival for cervical cancer.

リンク情報
DOI
https://doi.org/10.1097/IGC.0000000000000485
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26067860
ID情報
  • DOI : 10.1097/IGC.0000000000000485
  • PubMed ID : 26067860

エクスポート
BibTeX RIS