Papers

Peer-reviewed
Mar, 2011

Clinical significance of the ratio between the alpha 2 plasmin inhibitor-plasmin complex and the thrombin-antithrombin complex in advanced non-small cell lung cancer

MEDICAL ONCOLOGY
  • Katsuhiro Masago
    • ,
  • Shiro Fujita
    • ,
  • Tadashi Mio
    • ,
  • Yosuke Togashi
    • ,
  • Young Hak Kim
    • ,
  • Yukimasa Hatachi
    • ,
  • Akiko Fukuhara
    • ,
  • Kaoru Irisa
    • ,
  • Yuichi Sakamori
    • ,
  • Michiaki Mishima
Volume
28
Number
1
First page
351
Last page
356
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1007/s12032-010-9454-y
Publisher
HUMANA PRESS INC
The aims of this study are to: (a) confirm the prognostic significance of the procoagulant molecules D dimer, thrombin-antithrombin complex (TAT), and plasmin-alpha 2-plasmin inhibitor complex (PIC); (b) to evaluate hemostatic activation in patients with advanced non-small cell lung cancer (NSCLC); and (c) to delineate the relationships between markers of hemostasis and other clinical characteristics. In this study, a low PIC/TAT ratio and poor PS were significant independent negative prognostic factors for survival in patients with advanced NSCLC. The PIC/TAT ratio may become a surrogate marker for treatment with anticoagulants in the future.
Link information
DOI
https://doi.org/10.1007/s12032-010-9454-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20300980
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000287756000056&DestApp=WOS_CPL
ID information
  • DOI : 10.1007/s12032-010-9454-y
  • ISSN : 1357-0560
  • Pubmed ID : 20300980
  • Web of Science ID : WOS:000287756000056
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