論文

査読有り
2012年11月

Lhx1 in the proximal region of the optic vesicle permits neural retina development in the chicken

BIOLOGY OPEN
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回数 : 37
  • Takumi Kawaue
  • ,
  • Mayumi Okamoto
  • ,
  • Akane Matsuyo
  • ,
  • Junji Inoue
  • ,
  • Yuhki Ueda
  • ,
  • Sayuri Tomonari
  • ,
  • Sumihare Noji
  • ,
  • Hideyo Ohuchi

1
11
開始ページ
1083
終了ページ
1093
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1242/bio.20121396
出版者・発行元
COMPANY OF BIOLOGISTS LTD

How the eye forms has been one of the fundamental issues in developmental biology. The retinal anlage first appears as the optic vesicle (OV) evaginating from the forebrain. Subsequently, its distal portion invaginates to form the two-walled optic cup, which develops into the outer pigmented and inner neurosensory layers of the retina. Recent work has shown that this optic-cup morphogenesis proceeds as a self-organizing activity without any extrinsic molecules. However, intrinsic factors that regulate this process have not been elucidated. Here we show that a LIM-homeobox gene, Lhx1, normally expressed in the proximal region of the nascent OV, induces a second neurosensory retina formation from the outer pigmented retina when overexpressed in the chicken OV. Lhx2, another LIM-homeobox gene supposed to be involved in early OV formation, could not substitute this function of Lhx1, while Lhx5, closely related to Lhx1, could replace it. Conversely, knockdown of Lhx1 expression by RNA interference resulted in the formation of a small or pigmented vesicle. These results suggest that the proximal region demarcated by Lhx1 expression permits OV development, eventually dividing the two retinal domains. (C) 2012. Published by The Company of Biologists Ltd.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1242/bio.20121396
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000209205600005&DestApp=WOS_CPL