論文

査読有り 責任著者 国際誌
2020年11月22日

Dietary Acrylamide Intake and the Risk of Pancreatic Cancer: The Japan Public Health Center-Based Prospective Study.

Nutrients
  • Kumiko Kito
  • ,
  • Junko Ishihara
  • ,
  • Ayaka Kotemori
  • ,
  • Ling Zha
  • ,
  • Rong Liu
  • ,
  • Norie Sawada
  • ,
  • Motoki Iwasaki
  • ,
  • Tomotaka Sobue
  • ,
  • Shoichiro Tsugane

12
11
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/nu12113584

Acrylamide is a probable carcinogen in humans. Few studies have assessed dietary acrylamide intake and the risk of pancreatic cancer; however, these studies are based on Western populations. Our purpose was to investigate the association of dietary acrylamide intake with the risk of pancreatic cancer utilizing data from the Japan Public Health Center-based Prospective Study. We evaluated the data of 89,729 participants aged 45-74 years, who replied to a questionnaire on past medical history and lifestyle habits from 1995-1998. Dietary acrylamide intake was estimated utilizing a validated food frequency questionnaire. We calculated the hazard ratios and 95% confidence intervals by using Cox proportional-hazards regression models. The average follow-up was 15.2 years, and 576 cases of pancreatic cancer were diagnosed. In the multivariate-adjusted model, an association between dietary acrylamide intake and pancreatic cancer risk was not demonstrated (hazard ratio for the highest vs. lowest quartile = 0.83, 95% confidence interval: 0.65-1.05, p for trend = 0.07). Furthermore, in the analyses stratified by sex, smoking status, coffee consumption, green tea consumption, alcohol consumption, and body mass index, no significant association was detected. Dietary acrylamide intake was not associated with the pancreatic cancer risk in Japanese individuals.

リンク情報
DOI
https://doi.org/10.3390/nu12113584
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33266487
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700165
ID情報
  • DOI : 10.3390/nu12113584
  • PubMed ID : 33266487
  • PubMed Central 記事ID : PMC7700165

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