論文

査読有り 責任著者 国際誌
2020年12月17日

Acrylamide-Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire.

Nutrients
  • Junpei Yamamoto
  • Junko Ishihara
  • Yasuto Matsui
  • Tomonari Matsuda
  • Ayaka Kotemori
  • Yazhi Zheng
  • Daisuke Nakajima
  • Miho Terui
  • Akiko Shinohara
  • Shuichi Adachi
  • Junko Kawahara
  • Tomotaka Sobue
  • 全て表示

12
12
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/nu12123863

The levels of hemoglobin adducts of acrylamide (AA-Hb), a biomarker of acrylamide exposure, have not been reported for Japanese subjects. Herein, we determined the AA-Hb levels in a Japanese population and compared them with the estimated dietary intake from the duplicate diet method (DM) and a food frequency questionnaire (FFQ). One-day DM samples, FFQ, and blood samples were collected from 89 participants and analyzed for acrylamide. AA-Hb was analyzed using liquid chromatography tandem mass spectrometry and the N-alkyl Edman method. Participants were divided into tertiles of estimated acrylamide intake and geometric means (GMs) of AA-Hb adjusted for sex and smoking status. A stratified analysis according to smoking status was also performed. The average AA-Hb levels for all participants, never, past, and current smokers were 46, 38, 65, and 86 pmol/g Hb, respectively. GMs of AA-Hb levels in all participants were significantly associated with tertiles of estimated acrylamide intake from DM (p for trend = 0.02) and FFQ (p for trend = 0.04), although no association with smokers was observed. AA-Hb levels reflected smoking status, which were similar to values reported in Western populations, and they were associated with estimated dietary intake of acrylamide when adjusted for sex and smoking status.

リンク情報
DOI
https://doi.org/10.3390/nu12123863
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33348772
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767078
ID情報
  • DOI : 10.3390/nu12123863
  • PubMed ID : 33348772
  • PubMed Central 記事ID : PMC7767078

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