James Wing

Profile Information

Affiliation: (Associate Professor), Center for Infectious Disease Education and Research , Osaka University

Researcher number: 00648694
ORCID ID: https://orcid.org/0000-0002-3462-1003
J-GLOBAL ID: 202101001730780567
researchmap Member ID: R000021888

Research Interests

Research Areas

Awards

2021

2021 Osaka University Prize, Osaka University

Papers

Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19.

David G Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas N Søndergaard, Shuhei Sakakibara, Fuminori Sugihara, Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito …

Nature communications, 15(1) 6811-6811, Aug 9, 2024 Peer-reviewedLast authorCorresponding author
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation

Anees Ahmed, Ann M. Joseph, Jordan Zhou, Veronika Horn, Jazib Uddin, Mengze Lyu, Jeremy Goc, David Artis, Randy Longman, Gregory F. Sonnenberg …

Nature, 630(8018) 976-983, Jun 12, 2024 Peer-reviewed
Single cell suppression profiling of human regulatory T cells

Jonas Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James Wing

Research Square, May 2, 2024 Last authorCorresponding author
Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto …

Proceedings of the National Academy of Sciences of the United States of America, 121(17) e2402226121, Apr 23, 2024 Peer-reviewed
シングルセル情報とゲノム情報の統合解析によるCOVID-19重症化メカニズムの解明

枝廣龍哉, 白井雄也, 竹島雄介, 榊原修平, 山口勇太, 村上輝明, 森田貴義, 加藤保宏, Liu Yu-Chen, 元岡大祐 …

日本呼吸器学会誌, 13(増刊) 166-166, Mar, 2024
Non-classical CD45RBlo memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection.

David G. Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas Søndergaard, Shuhei Sakakibara, Fuminori Sugihara, Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito …

Research Square, Jan 25, 2024 Last authorCorresponding author
A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.

Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B Wing, Shimon Sakaguchi, Masahiro Yamamoto

Cell reports, 42(7) 112813-112813, Jul 12, 2023 Peer-reviewed
COVID-19 relapse associated with SARS-CoV-2 evasion from CD4+ T-cell recognition in an agammaglobulinemia patient.

Ryo Morita, Ritsuko Kubota-Koketsu, Xiuyuan Lu, Tadahiro Sasaki, Emi E Nakayama, Yu-Chen Liu, Daisuke Okuzaki, Daisuke Motooka, James Badger Wing, Yasunori Fujikawa …

iScience, 26(5) 106685-106685, May 19, 2023 Peer-reviewed
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu-Chen Liu, Daisuke Motooka …

Nature genetics, 55(5) 753-767, Apr 24, 2023 Peer-reviewed
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex

Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J. van Eerden, Janyerkye Tulyeu, Yu-Chen Liu …

Science Immunology, 8(81), Mar 31, 2023 Peer-reviewed
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda …

Proceedings of the National Academy of Sciences of the United States of America, 120(4) e2217902120, Jan 24, 2023 Peer-reviewedLead authorCorresponding author
Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn's disease.

Takehito Yokoi, Mari Murakami, Takako Kihara, Shigeto Seno, Mitsuru Arase, James Badger Wing, Jonas Nørskov Søndergaard, Ryuichi Kuwahara, Tomohiro Minagawa, Eri Oguro-Igashira …

Proceedings of the National Academy of Sciences of the United States of America, 120(1) e2204269120, Jan 3, 2023 Peer-reviewed
Elucidating the mechanism of COVID-19 severity by integrative analyses of single-cell and host genetics data

Ryuya Edahiro, Shirai Yuya, Takeshima Yusuke, Sakakibara Shuhei, Yamaguchi Yuta, Murakami Teruaki, Morita Takayoshi, Kato Yasuhiro, Liu Yu-Chen, Motooka Daisuke …

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 97 1-B-S05-2, 2023
Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer.

Kiyoshi Minohara, Masaki Imai, Takuma Matoba, James Badger Wing, Hiroaki Shime, Mizuyu Odanaka, Ryuta Uraki, Daisuke Kawakita, Tatsuya Toyama, Satoru Takahashi …

Cancer science, 114(4) 1256-1269, Dec 18, 2022 Peer-reviewed
Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.

Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori …

Nature communications, 13(1) 6948-6948, Nov 14, 2022 Peer-reviewed
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells.

Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, Jonas N Søndergaard, Teruaki Murakami, Saori Amiya, Shinichiro Nameki, Yuko Yoshimine, Takayoshi Morita, Yusuke Takeshima …

JCI insight, 7(22), Oct 25, 2022 Peer-reviewed
DOCK2 is involved in the host genetics and biology of severe COVID-19.

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee …

Nature, 609(7928) 754-760, Sep, 2022 Peer-reviewed
B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice.

Michelle S J Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi …

The Journal of experimental medicine, 219(2), Feb 7, 2022 Peer-reviewed
Using Mass Cytometry to Address Tfh and Tfr Heterogeneity

James B. Wing, Shimon Sakaguchi

Methods in Molecular Biology, 2380 47-57, 2022 Peer-reviewedInvitedLead author
Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia.

Takashi Mikami, Itaru Kato, James Badger Wing, Hiroo Ueno, Keiji Tasaka, Kuniaki Tanaka, Hirohito Kubota, Satoshi Saida, Katsutsugu Umeda, Hidefumi Hiramatsu …

Cancer science, 113(1) 41-52, Jan, 2022 Peer-reviewed

Misc.

COVID-19 relapse associated with SARS-CoV-2 evasion from CD4+ T-cell recognition in a persistently infected patient lacking humoral immune response

森田諒, 森田諒, 纐纈律子, LU Xiuyuan, 佐々木正大, 中山英美, LIU Yu-chen, 奥崎大介, 元岡大祐, WING James Badger …

日本ウイルス学会学術集会プログラム・予稿集(Web), 70th, 2023
マスサイトメトリーを用いた小児再発性B前駆細胞性急性リンパ性白血病の腫瘍免疫環境解析(Mass cytometric analysis of the tumor immune environment in children with recurrent BCP-ALL)

三上貴司, 加藤格, Wing James, 上野浩生, 田坂佳資, 田中邦昭, 窪田博仁, 才田聡, 梅田雄嗣, 平松英文 …

日本血液学会学術集会, 83回 OS2-4, Sep, 2021
最新型マスサイトメトリーを用いた小児白血病の骨髄免疫環境解析

三上貴司, 加藤格, Wing James B., 田中邦昭, 才田聡, 梅田雄嗣, 平松英文, 足立壮一, 祝迫惠子, 坂口志文 …

日本癌学会総会記事, 79回 OJ14-4, Oct, 2020 Peer-reviewed

Research Projects

The role of the transcription factor Tox2 in Treg and Tfh biology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Wing James
Role of Tfh and Tfr in autoimmunity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Wing James
Mechanisms of regulatory T-cell control of humoral immunity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

WING James, SAKAGUCHI Shimon, KUROSAKI Tomohiro, ISE Wataru
制御性T細胞によるB細胞機能の抑制

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2010 - 2012

坂口志文, WING James, WING JamesBadger

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