2017年
Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells.
PLoS ONE
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- 巻
- 12
- 号
- 9
- 開始ページ
- e0185394
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1371/journal.pone.0185394
Chondrocytes are known to be physiologically loaded with diverse physical factors such as compressive stress, shear stress and hydrostatic pressure. Although the effects of those mechanical stimuli onto various cell models have been widely studied, those of hypergravity have not yet been revealed clearly. Hereby, we hypothesized that the hypergravity affects relative positions of intracellular elements including nucleus and cytoskeletons due to their density differences, triggering mechanotransduction in the cell. The aim of this study was to investigate the effect of hypergravity on c-fos expression in the murine ATDC5 chondroprogenitor cells, as c-fos is a well known key regulator of cell proliferation and differentiation, including in chondrocytes. We first found that hypergravity down-regulated c-fos expression transiently via ROCK/Rho-GTP and PI3K signaling, and the down-regulation was suppressed by inhibition of actin polymerization.
- リンク情報
- ID情報
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- DOI : 10.1371/journal.pone.0185394
- PubMed ID : 28953959
- PubMed Central 記事ID : PMC5617206