Photocatalytic degradation of acetaminophen (Ace) in water was studied using Zeolite Socony Mobil-5 (ZSM-5) supported TiO2 materials, which were synthesized using a sol-gel method. The structural features of the photocatalysts were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and surface area (BET) measurements. The best loading content of TiO2 over ZSM-5 was 40wt% and the initial concentration of Ace was controlled at 15 mg L-1 with low intensity irradiations of 0.97 mW cm(-2), the degradation rate can reach to 96.6% after 180 mm irradiation. Hydroxylation and photolysis were proposed as the initial step for Ace degradation. Main reaction intermediates and products were identified by GC-MS analysis. Additionally, the material was regenerated four times, while the degradation of Ace remained at a higher level of approximately 90%. (c) 2015 Elsevier B.V. All rights reserved.