2018年
CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage
Science
- 巻
- 360
- 号
- 6384
- 開始ページ
- 50
- 終了ページ
- 57
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.aao2300
- 出版者・発行元
- American Association for the Advancement of Science
Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (a-amino-3hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage.
- ID情報
-
- DOI : 10.1126/science.aao2300
- ISSN : 1095-9203
- ISSN : 0036-8075
- PubMed ID : 29622647
- SCOPUS ID : 85045000257