論文

査読有り
2014年8月

Sensing viral invasion by RIG-I like receptors

CURRENT OPINION IN MICROBIOLOGY
  • Ji-Seung Yoo
  • ,
  • Hiroki Katol
  • ,
  • Takashi Fujita

20
開始ページ
131
終了ページ
138
記述言語
英語
掲載種別
DOI
10.1016/j.mib.2014.05.011
出版者・発行元
CURRENT BIOLOGY LTD

Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.

リンク情報
DOI
https://doi.org/10.1016/j.mib.2014.05.011
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000340991400022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.mib.2014.05.011
  • ISSN : 1369-5274
  • eISSN : 1879-0364
  • Web of Science ID : WOS:000340991400022

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