2014年8月
Sensing viral invasion by RIG-I like receptors
CURRENT OPINION IN MICROBIOLOGY
- ,
- ,
- 巻
- 20
- 号
- 開始ページ
- 131
- 終了ページ
- 138
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.mib.2014.05.011
- 出版者・発行元
- CURRENT BIOLOGY LTD
Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.
- リンク情報
- ID情報
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- DOI : 10.1016/j.mib.2014.05.011
- ISSN : 1369-5274
- eISSN : 1879-0364
- Web of Science ID : WOS:000340991400022