Jun K. YAMASHITA

Profile Information

Affiliation: Project Professor, Graduate School of Medicine/the University of Tokyo Hospital, The University of Tokyo

Degree: Doctor of Medicine(Mar, 1998, Kyoto University)

J-GLOBAL ID: 200901026845243856
researchmap Member ID: 1000258162

External link: https://www.u-tokyo.ac.jp/focus/ja/people/k0001_04592.html

Research Interests

Research Areas

Research History

Jul, 2022 - Present

特任教授, 細胞組織コミュニケーション講座, 東京大学大学院医学系研究科
2012 - 2022

教授, 増殖分化機構研究部門, 京都大学iPS細胞研究所
2007 - 2012

准教授（独立）, 幹細胞分化制御研究領域, 京都大学再生医科学研究所
2003 - 2007

助教授（独立）, 幹細胞分化制御研究領域, 京都大学再生医科学研究所
2002 - 2003

助教授, 分子遺伝学, 京都大学大学院医学研究科
2000 - 2002

助手, 分子遺伝学, 京都大学大学院医学研究科

Education

- 1998

Kyoto University
- 1998

Graduate School, Division of Medicine, Kyoto University
- 1990

Faculty of Medicine, Kyoto University
- 1990

Faculty of Medicine, Kyoto University

Awards

Aug, 2018

日本ベンチャー学会会長賞, JST

山下潤
Aug, 2016

産学連携功労者表彰・日本学術会議会長賞, 内閣府

山下潤
Mar, 2010

高峰譲吉研究奨励賞, 日本心血管内分泌代謝学会
Mar, 2009

Best Paper Award 2008, Basic Science, Circulation, Circulation, American Heart Association
2002

成人血管病研究振興財団・岡本研究奨励賞
2000

日本血管細胞生物学会 YIA最優秀賞
2000

日本内分泌学会若手研究者奨励賞
1997

日本循環器学会Young Investigator's Award
1995

日本動脈硬化学会学術奨励賞

Major Papers

202

Extracellular vesicles synchronize cellular phenotypes of differentiating cells

Tomohiro Minakawa, Tetsuya Matoba, Fumiyoshi Ishidate, Takahiro K. Fujiwara, Sho Takehana, Yasuhiko Tabata, Jun K. Yamashita

Journal of Extracellular Vesicles, 10(11), Sep, 2021 Peer-reviewed
Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82

Masafumi Takeda, Yasuharu Kanki, Hidetoshi Masumoto, Shunsuke Funakoshi, Takeshi Hatani, Hiroyuki Fukushima, Akashi Izumi-Taguchi, Yusuke Matsui, Teppei Shimamura, Yoshinori Yoshida …

Cell Reports, 22(2) 546-556, 2018 Peer-reviewed
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Masahide Kawatou, Hidetoshi Masumoto, Hiroyuki Fukushima, Gaku Morinaga, Ryuzo Sakata, Takashi Ashihara, Jun K. Yamashita

NATURE COMMUNICATIONS, 8, Oct, 2017 Peer-reviewed

Misc.

237

Regenerative medicine and stem cell biology in blood and lymphatic vessel development

68(4) 285-289, Jul, 2017
Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)

Takeshi Ikuno, Hidetoshi Masumoto, Kohei Yamamizu, Miki Yoshioka, Kenji Minakata, Tadashi Ikeda, Ryuzo Sakata, Jun K. Yamashita

PLOS ONE, 12(4), Apr, 2017
Human iPS cell-engineered 3D-cardiovascular tissue by stacking sheets with gelatin hydrogel microspheres for cardiac regenerative medicine

K. Yamamizu, T. Ikuno, H. Takakubo, H. Masumoto, K. Minakata, Y. Tabata, J. K. Yamashita

EUROPEAN HEART JOURNAL, 37 1211-1211, Aug, 2016
Cardiac tissue sheet including human iPS cell-derived cardiomyocytes and vascular cells restores impaired left ventricular systolic function of infarcted porcine hearts: a preclinical study

H. Masumoto, M. Ishigami, T. Aoki, F. Takai, T. Ikuno, M. Kawatoh, K. Minakata, T. Ikeda, R. Sakata, J. Yamashita

EUROPEAN HEART JOURNAL, 36 608-609, Aug, 2015
Differentiation toward cardiovascular cell populations from human iPS cells

252(11) 1176-1180, Mar 14, 2015
Scalable and highly efficient endothelial cell differentiation methods from human induced pluripotent stem cells based on monolayer and serum-free culture

T. Ikuno, H. Masumoto, A. Marui, K. Minakata, T. Ikeda, R. Sakata, J. K. Yamashita

EUROPEAN HEART JOURNAL, 35 110-110, Sep, 2014
Cell sheet transplantation to rat infarct heart using genomic integration-free human ips cells generated with episomal plasmid vectors: A strategy for tumor-free cardiac cell therapy

Masumoto H, Ikuno T, Okita K, Marui A, Minakata K, Ikeda T, Sakata R, Yamashita J

ISSCR 12th Annual Meeting, Jun, 2014 Peer-reviewed
PD-1-6 多能性幹細胞由来心臓組織シート移植 : 心筋組織再生を目指して(PD-1 パネルディスカッション(1)細胞・臓器移植における基礎的研究の最前線,第114回日本外科学会定期学術集会)

松尾武彦, 升本英利, 丸井晃, 南方謙二, 池田義, 山下潤, 坂田隆造

日本外科学会雑誌, 115(2) 169-169, Mar 5, 2014
Efficient endothelial cell differentiation protocol from human induced pluripotent stem cells based on monolayer and serum-free culture for realization of vascular regenerative medicine

T. Ikuno, H. Masumoto, A. Marui, T. Ikeda, R. Sakata, J. K. Yamashita

EUROPEAN HEART JOURNAL, 34 808-808, Aug, 2013
SY-7-7 細胞シート技術を用いた多能性幹細胞による心筋再生研究 : 機能的再生から組織再生へ(SY シンポジウム,第113回日本外科学会定期学術集会)

升本英利, 南方謙二, 丸井晃, 池田義, 清水達也, 岡野光夫, 山下潤, 坂田隆造

日本外科学会雑誌, 114(2) 126-126, Mar 5, 2013
A novel signaling-epigenetic linkage regulating stem cell “differentiation timing” from pluripotent state \nto ectoderm, endoderm, and mesoderm lineages

山下潤

新学術領域Neuro-Vascular Wiring Symposium 2012. 2012.11.12．奈良, Nov 12, 2012 Peer-reviewed
Transplantation of Cell Sheets with Human iPS Cell-derived Cardiomyocytes and Vascular Cells for Infarcted Hearts: A Basic Study

Hidetoshi Masumoto, Akira Marui, Tadashi Ikeda, Tatsuya Shimizu, Teruo Okano, Ryuzo Sakata, Jun K. Yamashita

CIRCULATION, 126(21), Nov, 2012
Angiopoietin-1 is Essential for Coronary Vein Formation in the Developing Heart

Yoh Arita, Yoshikazu Nakaoka, Taichi Marsunaga, Hiroyasu Kidoya, Kohei Yamamizu, Yuichiro Arima, Kaori Higuch, Manabu Shirai, Taku Yasui, Kuniyasu Ikeoka …

CIRCULATION, 126(21), Nov, 2012
オピオイドを取り巻く新しい話題 A.オピオイドとは何か 3.オピオイドが示す多彩な生理応答:血管新生やがん細胞増殖に及ぼす役割

葛巻直子, 山水康平, 濱田祐輔, 長澤阿津実, 山下潤, 成田年

ペインクリニック, 33 S251-S259, Oct 15, 2012
RSK4 Is a Novel Negative Regulator of Endothelial Differentiation via Direct Suppression of Protein Kinase A Activity

Taichi Matsunaga, Kohei Yamamizu, Kazuko K. Takeuchi, Mizuyo Kojima, Jun K. Takeuchi, Jun K. Yamashita

CIRCULATION RESEARCH, 111(4), Aug, 2012
Transplantation of cardiac tissue sheets including human induced pluripotent stem cell-derived defined cardiovascular cell populations ameliorates cardiac function after myocardial infarction

H. Masumoto, T. Ikeda, T. Shimizu, T. Okano, R. Sakata, J. K. Yamashita

EUROPEAN HEART JOURNAL, 33 432-432, Aug, 2012
Transplantation of Cardiac Tissue Sheets Including Defined Cardiovascular Cell Populations Differentiated from Human-Induced Pluripotent Stem Cells Ameliorates Cardiac Dysfunction After Subacute Myocardial Infarction

Hidetoshi Masumoto, Tadashi Ikeda, Tatsuya Shimizu, Teruo Okano, Ryuzo Sakata, Jun K. Yamashita

CIRCULATION RESEARCH, 111(4), Aug, 2012
多能性幹細胞を用いた心血管再生への多面的アプローチ

山下潤

CiRA mini Symposium. 2012.10.10．京都, 2012 Peer-reviewed
ES/iPS 細胞を用いた多面的心血管再生治療戦略

山下潤

京都大学医学部付属病院・iPS 細胞再生医学研究会．2012.7.20．京都, 2012 Peer-reviewed
ES/iPS 細胞の心血管再生への応用

山下潤

第48 回日本小児循環器学会シンポジウム．2012.7.6．京都, 2012 Peer-reviewed

Professional Memberships

Research Projects

細胞機能検出プローブを用いた３次元組織の動態・機能イメージング技術の開発

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

城潤一郎, 山下潤
Trials to reconsitute stem cell system in the heart for cardiac regeneration

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Pioneering), Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Identification of molecular mechanisms of RNF213-related occlusive cerebrovascular diseases and development of new treatment strategies

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Miyamoto Susumu
分化再生と生体恒常性を制御するエクソソームの新しい細胞同調機能の解明とナノ粒子による生体機能制御への応用

戦略的な研究開発の推進戦略的創造研究推進事業 CREST, 科学技術振興機構, 2017 - 2022

山下潤
Exploration of novel in vitro lethal arrhythmia models with 3D tissues from human iPS cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Yamashita Jun
Next generation in vitro tissue/organ models with 3D tissue from stem cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Yamashita Jun, Kawatou Masahide
In vitro evaluation system for cardiac contraction using human iPS cell-derived 3-D cardiac tissue

Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Nov, 2015 - Mar, 2018
Novel cardiomyocyte-fated progenitors from human iPS cells for cardiac regeneration

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Yamashita Jun, TAKEDA Masafumi
Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Sakaguchi Hisashi, YAMASHITA JUN, MASUMOTO HIDETOSHI
Development of human iPS cell-derived multidisciplinary thick viable organized tissues aiming for myocardial regenerative therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Nakata Tomohiro, YAMASHITA JUN, MASUMOTO HIDETOSHI
Development of a new vascular regenerative therapy for severe limb ischemia by the transplantation of human iPS cell-derived vascular cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

SAKATA RYUZO, YAMASHITA JUN, MASUMOTO HIDETOSHI
Anti-vascular diseases approach through the analysis of vascular-bed dependent diversity and activation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Minami Takashi, KANKI Yasuharu, ABURATANI Hiroyuki, YAMASHITA Jun
Elucidation of novel mechanism of phenotype synchronization among cardiomyocytes

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2017

Yamashita Jun
Elucidation of pathogenesis and development of therapy of lipodystrophy using human iPS cell-derived adipocytes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Hosoda Kiminori, TAKAHASHI Kazutoshi, YAMASHITA Jun, NAKAO Kazuki, Ebihara Ken, SONE Masakatssu, SAKURAI Hidetoshi, FUJIKURA Junji, NOGUCHI Michio
Euro-Japan collaborative field work for the understanding of symbiotic evolution of marine microbes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Nakao Yoichi, YAMASHITA Jun, KIMURA Hiroshi, IKURA Tsuyoshi
Angiopoietin-1-mediated vascular development and maturation in the developing heart

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

NAKAOKA YOSHIKAZU, YAMASHITA JUN, KOMURO ISSEI
Drug discovery for the treatment of severe heart failure

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Tsuneyosi Hiroshi, SAKATA RYUZO, YAMASHITA JUN
HCN4-luciferase knock-in mouse is a new tool for pacemaker cell reprogramming

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

TAKANO Makoto, ITOH Masayuki, TAKEYA Mitsue, YAMASHITA Jun, KUWAHARA Koichiro
Regulation of differentiation, regeneration, and homeostasis via signaling-epigenome interaction

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2015

JUN YAMASHITA
Development of a novel vascular-targeting therapy through stem cell research

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

YAMASHITA Jun

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Misc.

Professional Memberships

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