2020年9月
Total Synthesis of Dictyodendrins A–F by the Gold‐Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole
Chemistry – A European Journal
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- 巻
- 26
- 号
- 49
- 開始ページ
- 11150
- 終了ページ
- 11157
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.202001950
- 出版者・発行元
- Wiley
The total synthesis of dictyodendrins A-F was achieved by using the gold(I)-catalyzed annulation of a conjugated diyne with N-Boc-pyrrole for direct construction of the pyrrolo[2,3-c]carbazole scaffold. Late-stage functionalization of the resulting pyrrolo[2,3-c]carbazole to introduce various substituents provided divergent access to dictyodendrins. Some dictyodendrin analogues exhibited inhibitory activities toward CDK2/CycA2 and GSK3.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.202001950
- ISSN : 0947-6539
- eISSN : 1521-3765
- PubMed ID : 32364649