Jun Nakayama

Profile Information

Affiliation: Researcher, Department of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute
: National Cancer Center
: Kansai Medical University

Degree: Ph.D.(Mar, 2019, Waseda University)

Contact information: jun.nakayamaoici.jp
Researcher number: 30801237
ORCID ID: https://orcid.org/0000-0001-8844-4295
J-GLOBAL ID: 201701007086844902
researchmap Member ID: B000273287

Github https://github.com/JunNakayama

Research Interests

Research Areas

Research History

Sep, 2023 - Present

Department of Oncogenesis and Growth Regulation, Research Insititute, Osaka International Cancer Institute
Apr, 2023 - Aug, 2023

Research Institute, Laboratory of Integrative Oncology, National Cancer Center
Apr, 2020 - Mar, 2023

Laboratory of Integrative Oncology, Division of Cellular Signaling, National Cancer Center, Research Institute
Apr, 2020 - Mar, 2023

Research Fellow, Japan Society for the Promotion of Science
Apr, 2019 - Mar, 2020

Faculty of Science and Engineering, Waseda University
Apr, 2017 - Mar, 2019

Faculty of Science and Engineering, Waseda University

Education

Apr, 2016 - Mar, 2019

Graduate School of Advanced Science and Engineering, Waseda University
Apr, 2014 - Mar, 2016

Graduate School of Advanced Science and Engineering, Waseda University
Apr, 2010 - Mar, 2014

School of Advanced Science and Engineering, Waseda University

Awards

Mar, 2024

2023年度がん研究助成奨励金, 1細胞解析における不均一性定量化手法の開発と乳がんへの応用, 公益財団法人大阪対がん協会

中山淳
Jan, 2024

APS Select Award in Physiological Genomics, The American Physiological Society

Karen Yamaguchi, Jun Nakayama, Tomofumi Yamamoto, Kentaro Semba, Tatsuo Shirota, Yusuke Yamamoto
2023

日本がん転移学会研究奨励賞

中山淳
Apr, 2022

Top Cited Article Award 2020-2021 'Genes to Cells', WILEY

Jun Nakayama
Oct, 2018

SPI大賞（最優秀賞）, In vivoイメージングフォーラム2018

中山淳
Sep, 2018

ベストポスター賞, 新学術領域研究「先端モデル動物支援プラットフォーム」平成30年度若手支援技術講習会

中山淳
Sep, 2017

ベストトーク賞, 新学術領域研究「先端モデル動物支援プラットフォーム」平成29年度若手支援技術講習会

中山淳
Jun, 2017

ポスター賞, 第21回日本がん分子標的治療学会学術集会

中山淳
Sep, 2016

ベストポスター賞, 新学術領域研究「先端モデル動物支援プラットフォーム」平成28年度若手支援技術講習会

中山淳

Major Papers

Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR

Kojiro Ishibashi, Toshiya Ichinose, Riki Kadokawa, Ryo Mizutani, Sadahiro Iwabuchi, Sumihito Togi, Hiroki Ura, Shoichiro Tange, Keiko Shinjo, Jun Nakayama …

Developmental Cell, Feb, 2024 Peer-reviewed
Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer

Takahiko Murayama, Jun Nakayama, Xinpei Jiang, Kenichi Miyata, Alexander D. Morris, Kathy Q. Cai, Rahul M. Prasad, Xueying Ma, Andrey Efimov, Neel Belani …

Cancer Discovery, Jan 8, 2024 Peer-reviewed
Metastatic potentials classified with hypoxia‐inducible factor 1 downstream genes in pan‐cancer cell lines

Kazuya Nakamichi, Yusuke Yamamoto, Kentaro Semba, Jun Nakayama

Genes to Cells, Dec 29, 2023 Peer-reviewedLast authorCorresponding author
Collagen induction of immune cells in the mammary glands during pregnancy

Karen Yamaguchi, Jun Nakayama, Tomofumi Yamamoto, Kentaro Semba, Tatsuo Shirota, Yusuke Yamamoto

Physiological Genomics, Nov 13, 2023 Peer-reviewedLead authorCorresponding author
Spatial exosome analysis using cellulose nanofiber sheets reveals the location heterogeneity of extracellular vesicles

Akira Yokoi, Kosuke Yoshida, Hirotaka Koga, Masami Kitagawa, Yukari Nagao, Mikiko Iida, Shota Kawaguchi, Min Zhang, Jun Nakayama, Yusuke Yamamoto …

Nature Communications, 14(1), Nov 8, 2023 Peer-reviewed
Cancer-prone Phenotypes and Gene Expression Heterogeneity at Single-cell Resolution in Cigarette-smoking Lungs

Jun Nakayama, Yusuke Yamamoto

Cancer Research Communications, Nov 1, 2023 Peer-reviewedLead authorCorresponding author
Targeting c-Jun is a potential therapy for luminal breast cancer bone metastasis

Yuxuan Han, Shota Katayama, Mitsuru Futakuchi, Kazuya Nakamichi, Yutaro Wakabayashi, Mai Sakamoto, Jun Nakayama, Kentaro Semba

Molecular Cancer Research, Jun 13, 2023 Peer-reviewedCorresponding author
Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer

Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto, Kentaro Semba

Cancer Cell International, 23(1) 57-57, Apr, 2023 Peer-reviewedCorresponding author
HOXB7 induces STAT3‐mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma, Mai Sakamoto, Shota Katayama, Atsuka Matsui, Kazuya Nakamichi, Naoki Goshima, Shinya Watanabe, Jun Nakayama, Kentaro Semba

Genes to Cells, Jan 27, 2023 Peer-reviewedCorresponding author
Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease

Naoaki Watanabe†, Yu Fujita†, Jun Nakayama†, Yutaro Mori, Tsukasa Kadota, Yusuke Hayashi, Iwao Shimomura, Takashi Ohtsuka, Koji Okamoto, Jun Araya …

American Journal of Respiratory Cell and Molecular Biology, 67(6) 708-719, Dec, 2022 Peer-reviewedLead author
Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ

Momoko Tokura†, Jun Nakayama†, Marta Prieto-Vila, Sho Shiino, Masayuki Yoshida, Tomofumi Yamamoto, Naoaki Watanabe, Shin Takayama, Yutaka Suzuki, Koji Okamoto …

Cancer Research, 82(18) 3236-3248, Sep 16, 2022 Peer-reviewedLead author
Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

Jun Nakayama, Hiroko Matsunaga, Koji Arikawa, Takuya Yoda, Masahito Hosokawa, Haruko Takeyama, Yusuke Yamamoto, Kentaro Semba

Disease Models & Mechanisms, 15(6), Jun 1, 2022 Peer-reviewedLead authorCorresponding author
Aberrant activation of cell cycle-related kinases and the potential therapeutic impact of PLK1 or CHEK1 inhibition in uterine leiomyosarcoma

Kosuke Yoshida, Akira Yokoi, Tomofumi Yamamoto, Yusuke Hayashi, Jun Nakayama, Tsuyoshi Yokoi, Hiroshi Yoshida, Tomoyasu Kato, Hiroaki Kajiyama, Yusuke Yamamoto

Clinical cancer research : an official journal of the American Association for Cancer Research, 28(10) 2147-2159, Mar 18, 2022 Peer-reviewed
Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models

Yuxuan Han, Kazushi Azuma, Shinya Watanabe, Kentaro Semba, Jun Nakayama

Clinical & Experimental Metastasis, 39(3) 467-477, Feb 1, 2022 Peer-reviewedLast authorCorresponding author
SORT1/LAMP2-mediated Extracellular Vesicle Secretion and Cell Adhesion Are Linked to Lenalidomide Resistance in Multiple Myeloma

Tomofumi Yamamoto, Jun Nakayama, Yusuke Yamamoto, Masahiko Kuroda, Yutaka Hattori, Takahiro Ochiya

Blood Advances, Jan 3, 2022 Peer-reviewed
Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction

Shiyu Ayukawa, Nagisa Kamoshita†, Jun Nakayama†, Ryohei Teramoto, Novalia Pishesha, Kenji Ohba, Nanami Sato, Kei Kozawa, Hikari Abe, Kentaro Semba …

Nature Immunology, 22(11) 1391-1402, Oct 22, 2021 Peer-reviewed
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada …

Life Science Alliance, 4(9) e202101095-e202101095, Jun, 2021 Peer-reviewed
Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intra-caudal arterial injection

Han Y†, Nakayama J†, Hayashi Y, Jeong S, Futakuchi M, Ito E, Watanabe S, Semba K

Genes to Cells, 25(2) 111-123, Feb, 2020 Peer-reviewedLead authorCorresponding author
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells

Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama …

NATURE COMMUNICATIONS, 8(1) 1246, Nov, 2017 Peer-reviewed
Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection

Jun Nakayama, Emi Ito, Jiro Fujimoto, Shinya Watanabe, Kentaro Semba

INTERNATIONAL JOURNAL OF ONCOLOGY, 50(2) 497-504, Feb, 2017 Peer-reviewedLead author

Books and Other Publications

RNA-Seqデータ解析 : WETラボのための超鉄板レシピ : ヒトから非モデル生物まで公共データの活用も充実

中山淳, 山本雄介 (Role: Contributor, コラムバルク解析とシングルセル解析)

羊土社, Oct, 2023 (ISBN: 9784758122672)

Major Research Projects

Elucidation of the diversity and treatment resistance of multiple breast cancer stem cell populations

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
乳腺浸潤性小葉がんにおけるがん幹細胞集団多様性の解析

がん研究助成事業, 公益財団法人がん研究振興財団, Apr, 2024 - Mar, 2025

中山淳
多発性小葉がんの空間的不均一性の解明

2023年度医学系研究助成(がん領域(基礎)), 公益財団法人武田科学振興財団, Sep, 2023 - Mar, 2025

中山淳
1細胞解析による浸潤性小葉がんの腫瘍内不均一性の解明

2022年度研究助成金, 公益財団法人神澤医学研究振興財団, Apr, 2023 - Mar, 2024

中山淳
消化器がん形成過程における細菌由来RNAを介した細菌・宿主間情報伝達の解明と血中RNA診断への応用

革新的がん医療実用化研究事業, 日本医療研究開発機構（AMED）, 2021 - Mar, 2024

松﨑潤太郎
野生型FLT3を標的とした新規低分子化合物シーズの創製と評価

令和4年度研究助成金, 一般財団法人横山臨床薬理研究助成基金, Dec, 2022 - Jun, 2023

中山淳, 森屋亮平, 山元智史
1細胞メタ解析によるCOPD本態解明と診断バイオマーカーの探索

2021年度GSKジャパン研究助成, グラクソ・スミスクラインジャパン, Sep, 2021 - Mar, 2023

中山淳
Verification of "DCIS to IDC hypothesis" and exploration for DCIS diagnostic markers

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2023

Nakayama Jun
Analysis of Cancer Evolution by Single Cell Amplicomics

Grants-in-Aid for Scientific Research, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
非古典的NFκB経路が制御するトリプルネガティブ乳がん悪性化機構の解明

がん研究助成事業, 公益財団法人がん研究振興財団, Apr, 2021 - Mar, 2022

中山淳
マルチオミックス解析による腫瘍間・腫瘍内アンプリコン不均一性の解明

研究奨励金（Ⅰ）, 公益財団法人東京生化学研究会, Feb, 2021 - Mar, 2022

中山淳
Multi-Organ Metastasis of Breast Cancer Regulated by ERBB2-Amplicon

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Nakayama Jun

Professional Memberships

Academic Activities

PathPort どこでも病理ラボ分科会サポートメンバー

Planning, management, etc.

Apr 1, 2024 - Present

Major Presentations

Single-cell transcriptomics for evaluating early clonal expansion in breast cancer

中山淳, 山本雄介

Dec 6, 2023
Single-cell RNA-seqの原理と最先端の解析基盤

中山淳

山形大学医学部病理学・病理診断学講座大学院セミナー, May 25, 2023 Invited
次世代シークエンサーを用いた最先端の遺伝子発現解析技術

中山淳

愛媛大学プロテオサイエンスセンター細胞増殖・腫瘍制御部門生化学教育セミナー, May 17, 2023 Invited
公共データベースを利用した1細胞メタ解析

中山淳

第45回日本分子生物学会年会フォーラム「公共データのメタ解析でバイオDX」, Nov 30, 2022 Invited
1細胞メタ解析による細胞集団不均一性の理解

中山淳

慶應義塾大学薬学部第2回サイヤンスセミナー, Sep 2, 2022 Invited
1細胞メタ解析による細胞集団不均一性と病態変容の理解

中山淳

筑波大学内分泌代謝・糖尿病内科セミナー招待講演, Aug 22, 2022 Invited
Cigarette Smoking Lung Atlasの1細胞メタ解析

中山淳, 山本雄介

第80回日本癌学会学術総会 International Session, Oct 2, 2021
Cigarette Smoking Lung Atlasの構築と1細胞メタ解析

中山淳, 山本雄介

文部科学省新学術領域研究学術研究支援基盤形成「先端モデル動物支援プラットフォーム」2021年度若手支援技術講習会, Sep 6, 2021 Invited
新たな高転移株樹立を通したがん転移研究

中山淳

大阪大学蛋白質研究所セミナー「がん研究の新機軸」, Jul 4, 2019 Invited
発がん/転移制御遺伝子の同定法

中山淳, 仙波憲太郎

理研IMS Immunobiology Semminar, May 10, 2019 Invited
同所性乳がん高転移株の樹立とそのトランスクリプトーム解析

中山淳

愛媛大学プロテオサイエンスセンター PROSセミナー, Apr 8, 2019 Invited
Establishment and Characterization of highly metastatic breast cancer cell line by orthotopic transplantation

Jun Nakayama, Jiro Fujimoto, Kentaro Semba

Metastasis Research Society 17th Biennial Congress, Jul 31, 2018
Establishment and Characterization of highly metastatic breast cancer cell line by orthotopic transplantation

Jun Nakayama, Jiro Fujimoto, Kentaro Semba

EACR-MRS Conference Seed and Soil: In Vivo Models of Metastasis, Nov 27, 2017

Teaching Experience

Major Misc.

114

Metastatic potentials classified with hypoxia-inducible factor 1 downstream gene in pan-cancer cell lines

Kazuya Nakamichi, Kentaro Semba, Jun Nakayama

bioRxiv, May, 2023 Last authorCorresponding author
Targeting c-Jun is a potential therapy of luminal breast cancer bone metastasis

Yuxuan Han, Mitsuru Futakuchi, Kazuya Nakamichi, Yutaro Wakabayashi, Mai Sakamoto, Jun Nakayama, Kentaro Semba

bioRxiv, Jul 18, 2022 Corresponding author
Integrative transcriptomics analysis for uterine leiomyosarcoma identifies aberrant activation of cell cycle-dependent kinases and their potential therapeutic significance.

Kosuke Yoshida, Akira Yokoi, Tomofumi Yamamoto, Yusuke Hayashi, Jun Nakayama, Tsuyoshi Yokoi, Hiroshi Yoshida, Tomoyasu Kato, Hiroaki Kajiyama, Yusuke Yamamoto

medRxiv, Jan 7, 2022
Single-cell meta-analysis of cigarette smoking lung atlas

Jun Nakayama, Yusuke Yamamoto

bioRxiv, Dec 10, 2021 Lead authorCorresponding author
Spatial transcriptomics reveals the two cancer stem cell-like populations in triple-negative breast cancer

Jun Nakayama, Hiroko Matsunaga, Koji Arikawa, Takuya Yoda, Masahito Hosokawa, Haruko Takeyama, Yusuke Yamamoto, Kentaro Semba

bioRxiv, Oct 21, 2021 Lead authorCorresponding author
Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models

Yuxuan Han, Kazushi Azuma, Shinya Watanabe, Kentaro Semba, Jun Nakayama

bioRxiv, Oct 20, 2021 Last authorCorresponding author
Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto, Kentaro Semba

bioRxiv, Aug 28, 2021 Corresponding author
HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma, Mai Sakamoto, Jun Nakayama, Shota Katayama, Atsuka Matsui, Naoki Goshima, Shinya Watanabe, Kentaro Semba

bioRxiv, May 17, 2021 Corresponding author
Anomalous epithelial variations and ectopic inflammatory response in chronic obstructive pulmonary disease

Naoaki Watanabe†, Jun Nakayama†, Yu Fujita, Yutaro Mori, Tsukasa Kadota, Iwao Shimomura, Takashi Ohtsuka, Koji Okamoto, Jun Araya, Kazuyoshi Kuwano …

medRxiv, Dec 7, 2020 Lead author

Major Works

Gene Expression Omnibus: GSE256193

Karen Yamaguchi, Yusuke Yamamoto, Jun Nakayama

Feb 21, 2024 Database
Gene Expression Omnibus: GSE256192

Karen Yamaguchi, Kenichi Miyata, Reo Maruyama, Yusuke Yamamoto, Jun Nakayama

Feb 21, 2024 Database
Gene Expression Omnibus: GSE196208

Momoko Tokura, Jun Nakayama, Yusuke Yamamoto

Feb 7, 2022 Database
Gene Expression Omnibus: GSE195861

Momoko Tokura, Jun Nakayama, Prieto-Vila Marta, Yusuke Yamamoto

Feb 1, 2022 Database
Gene Expression Omnibus: GSE184720

Jun Nakayama, Kentaro Semba

Sep 24, 2021 Database
Gene Expression Omnibus: GSE182261

Yusuke Hayashi, Jun Nakayama, Yusuke Yamamoto, Kentaro Semba

Aug 17, 2021 Database
Japanese Genotype-phenotype Archive: JGAS000309

Jun Nakayama, Yusuke Yamamoto, Momoko Tokura, Yutaka Suzuki, Yuuta Kuze

Jul 7, 2021 Database

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Books and Other Publications

Major Research Projects

Professional Memberships

Academic Activities

Major Presentations

Teaching Experience

Major Misc.

Major Works

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