Jonas Søndergaard

Profile Information

Affiliation: Dr. (Specially Appointed Assistant Professor (Full-time)), Center for Infectious Disease Education and Research (CiDER), Osaka University

Other name(s) (e.g. nickname): Jonas Soendergaard
Researcher number: 50900213
ORCID ID: https://orcid.org/0000-0002-4438-6756
J-GLOBAL ID: 202101002028239595
researchmap Member ID: R000015691

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Specially Appointed Assistant Professor, Center for Infectious Disease Education and Research, Osaka University
Nov, 2020 - Apr, 2021

Specially Appointed Researcher (Advanced Postdoc), WPI Immunology Frontier Research Center, Osaka University
Jul, 2018 - Aug, 2020

Senior Research Specialist (Senior Postdoc), Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Science for Life Laboratory
Jul, 2016 - Jul, 2018

Postdoctoral Research Fellow, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Science for Life Laboratory
Jul, 2012 - Jul, 2016

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences

Education

Jan, 2009 - Jun, 2012

Ph.D. research project: “Immune recognition of latency-instigating pathogens by human dendritic cells”., Department of Systems Biology, Technical University of Denmark
Sep, 2003 - Dec, 2008

Master of Science in Biotechnological Engineering, Technical University of Denmark
Jan, 2008 - Nov, 2008

Master thesis research project: “Anti-tumor activity of protein kinase inhibitor”, Jonsson Comprehensive Cancer Center, Tumor Immunology Program, University of California, Los Angeles
Aug, 2006 - Jul, 2007

Exchange Student, University of Illinois at Urbana-Champaign

Awards

Papers

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto …

Proceedings of the National Academy of Sciences of the United States of America, 121(17) e2402226121, Apr 23, 2024
SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency.

Laurent Schmied, Thuy T Luu, Jonas N Søndergaard, Sophia H Hald, Stephan Meinke, Dara K Mohammad, Sunitha B Singh, Corinna Mayer, Giovanna Perinetti Casoni, Michael Chrobok …

Science signaling, 16(780) eabq0752, Apr 11, 2023 Peer-reviewed
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda …

Proceedings of the National Academy of Sciences of the United States of America, 120(4) e2217902120, Jan 24, 2023 Peer-reviewedLead author
Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn's disease.

Takehito Yokoi, Mari Murakami, Takako Kihara, Shigeto Seno, Mitsuru Arase, James Badger Wing, Jonas Nørskov Søndergaard, Ryuichi Kuwahara, Tomohiro Minagawa, Eri Oguro-Igashira …

Proceedings of the National Academy of Sciences of the United States of America, 120(1) e2204269120, Jan 3, 2023 Peer-reviewed
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells.

Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, Jonas N Søndergaard, Teruaki Murakami, Saori Amiya, Shinichiro Nameki, Yuko Yoshimine, Takayoshi Morita, Yusuke Takeshima …

JCI insight, 7(22), Oct 25, 2022 Peer-reviewed
Target-enriched nanopore sequencing and de novo assembly reveals cooccurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells

Keyi Geng, Lara G Merino, Linda Wedemann, Aniek Martens, Malgorzata Sobota, Yerma P Sanchez, Jonas Norskov Sondergaard, Robert J. White, Claudia Kutter

Genome Research, gr.276901.122-gr.276901.122, Sep 30, 2022 Peer-reviewed
Control of NK cell tolerance in MHC class I-deficiency by regulated SHP-1 localization to the activating immune synapse

Laurent Schmied, Thuy T. Luu, Jonas N. Søndergaard, Stephan Meinke, Dara K. Mohammad, Sunitha B. Singh, Corinna Mayer, Giovanna P. Casoni, Michael Chrobok, Heinrich Schlums …

bioRxiv, Mar 9, 2022
Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions.

N Balneger, L A M Cornelissen, M Wassink, S J Moons, T J Boltje, Y E Bar-Ephraim, K K Das, J N Søndergaard, C Büll, G J Adema

Cellular and molecular life sciences : CMLS, 79(2) 98-98, Jan 28, 2022 Peer-reviewed
CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism

Jonas Nørskov Søndergaard, Christian Sommerauer, Ionut Atanasoai, Laura C Hinte, Keyi Geng, Giulia Guiducci, Lars Bräutigam, Myriam Aouadi, Lovorka Stojic, Isabel Barragan …

Gut, gutjnl-2021, Jan 12, 2022 Peer-reviewedLead author
Regulatory T-cells are central hubs for age-, sex- and severity-associated cellular networks during COVID-19

Jonas Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shira, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda …

medRxiv, Jan 6, 2022 Lead author
FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development.

Thuy T Luu, Jonas Nørskov Søndergaard, Lucía Peña-Pérez, Shabnam Kharazi, Aleksandra Krstic, Stephan Meinke, Laurent Schmied, Nicolai Frengen, Yaser Heshmati, Marcin Kierczak …

Frontiers in immunology, 13 854312-854312, 2022 Peer-reviewed
Isolation and Characterization of Both Human and Mouse Tfh/Tfr Cells.

Tulyeu J, Søndergaard JN, Sakaguchi S, Wing JB

Current protocols, 1(11) e283, Nov, 2021 Peer-reviewed
DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis.

Chunling Tang, Renske J E van den Bijgaart, Maaike W G Looman, Vassilis Triantis, Jonas Nørskov Søndergaard, Marleen Ansems, Gosse J Adema

Developmental biology, 463(2) 101-109, Jul 15, 2020 Peer-reviewed
Successful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids.

Jonas Nørskov Søndergaard, Keyi Geng, Christian Sommerauer, Ionut Atanasoai, Xiushan Yin, Claudia Kutter

Communications biology, 3(1) 319-319, Jun 19, 2020 Peer-reviewedLead author
A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.

Kunal Das Mahapatra, Lorenzo Pasquali, Jonas Nørskov Søndergaard, Jan Lapins, István Balazs Nemeth, Eszter Baltás, Lajos Kemény, Bernhard Homey, Liviu-Ionut Moldovan, Jørgen Kjems …

Scientific reports, 10(1) 3637-3637, Feb 27, 2020 Peer-reviewed
Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4.

Jonas Nørskov Søndergaard, Simon J van Heeringen, Maaike W G Looman, Chunling Tang, Vassilis Triantis, Pauline Louche, Eva M Janssen-Megens, Anieta M Sieuwerts, John W M Martens, Colin Logie …

Frontiers in immunology, 9 1420-1420, 2018 Peer-reviewedLead author
Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation.

Christian Büll, Estel Collado-Camps, Esther D Kers-Rebel, Torben Heise, Jonas N Søndergaard, Martijn H den Brok, Barbara M Schulte, Thomas J Boltje, Gosse J Adema

Immunology and cell biology, 95(4) 408-415, Apr, 2017 Peer-reviewed
DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation.

Jonas Nørskov Søndergaard, Susanna Poghosyan, Saartje Hontelez, Pauline Louche, Maaike W G Looman, Marleen Ansems, Gosse J Adema

Journal of immunology (Baltimore, Md. : 1950), 195(4) 1498-505, Aug 15, 2015 Peer-reviewedLead author
DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.

Marleen Ansems, Jonas Nørskov Søndergaard, Anieta M Sieuwerts, Maaike W G Looman, Marcel Smid, Annemarie M A de Graaf, Vanja de Weerd, Malou Zuidscherwoude, John A Foekens, John W M Martens …

Breast cancer research and treatment, 149(3) 693-703, Feb, 2015 Peer-reviewedLead author
Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-γ.

Jonas Nørskov Søndergaard, Janne Marie Laursen, Lisbeth Buus Rosholm, Susanne Brix

International immunology, 26(12) 705-16, Dec, 2014 Peer-reviewedLead author

Teaching Experience

Academic Activities

Bioinformatics Github scripts: https://github.com/jonasns

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2015 - Present

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Teaching Experience

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