ジョージジョセフ (Joseph George) - マイポータル

基本情報

所属: Kanazawa Medical University Hepatology Associate Professor (Associate Professor)

学位: 医学博士
生化学博士

研究者番号: 60791176
J-GLOBAL ID: 202001007648449640
researchmap会員ID: R000000198

外部リンク: https://www.josorge.com

経歴

2014年6月 - 2016年3月

Mayo Clinic, Jacksonville, Florida, USA;, Cancer Biology;
2009年7月 - 2010年8月

Mount Sinai School of Medicine, New York;, Division of Liver Diseases,Department of Medicine;

論文

Molecular pathogenesis of metabolic dysfunction-associated steatotic liver disease, steatohepatitis, hepatic fibrosis and liver cirrhosis.

Saito Takashi, Tsuchishima Mutsumi, Tsutsumi Mikihiro, George Joseph

Journal of Cellular and Molecular Medicine 28(12) e18491 2024年6月査読有り
Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches.

George Joseph, Lu Yongke, Tsuchishima Mutsumi, Tsutsumi Mikihiro

Redox biology 75 103258 2024年6月査読有り
Interaction between fatty acid oxidation and ethanol metabolism in liver.

Lu Yongke, George Joseph

American Journal of Physiology. Gastrointestinal and Liver Physiology 326(5) G483-G494. 2024年5月査読有り
Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis.

Yamagata Mitsuyoshi, Tsuchishima Mutsumi, Saito Takashi, Tsutsumi Mikihiro, George Joseph

Clinical Science (Lond) 138(5) 327-34905 2024年3月査読有り
Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats

Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchisihma, Mikihiro Tsutsumi

Molecular Medicine 28(1) 143 2022年11月査読有り
Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis.

George Joseph, Tsuchishima Mutsumi, Tsutsumi Mikihiro

Biomedicine & Pharmacotherapy 151 113111 2022年7月査読有り
Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis

Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George

British Journal of Pharmacology 177(22) 5195-5207 2020年11月査読有り
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models

Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi

Journal of Molecular Medicine 98(9) 1203-1213 2020年9月査読有り
Metabolism and interactions of antileprosy drugs

Joseph George

Biochemical Pharmacology 177 113993 2020年7月査読有り
Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats

Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro

European Journal of Pharmacology 863 172681 2019年12月査読有り
Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi

Cell Death & Disease 10 18 2019年1月査読有り
Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis

Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima

Scientific Reports 9 708 2019年1月査読有り
Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice.

George Joseph, Yan Irene K, Patel Tushar

Laboratory Investigation 98(7) 895-910 2018年査読有り
Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry.

Joseph George

Biological Chemistry 399(5) 499-509 2018年査読有り
MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice

George, Joseph, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21(12) 3821-3835 2017年査読有り
GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats.

K. Tamura, N. Hayashi, J. George, M. Toshikuni, T. Arisawa, J. Hiratake, M. Tsuchishima, M. Tsutsumi

American Journal of Physiology: Gastrointestinal and Liver Physiology 311(2) G305-G312 2016年査読有り
Serum endocan as a survival predictor for patients with liver cirrhosis

N. Toshikuni, K.Ozaki, J. George, M. Tsutsumi

Canadian Journal of Gastroenterology and Hepatology 29(8) 427-430 2015年査読有り
Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection

Y. Matsue, M. Tsutsumi, N. Hayashi, T. Saito, M. Tsuchishima, N. Toshikuni, T. Arisawa, J. George

PLoS One 10(3) e0118744-e0118744 2015年査読有り
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Joseph George, Tushar Patel

Seminars in Liver Disease 35(1) 63-74 2015年査読有り
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis

T. Minato, M. Tsutsumi, M. Tsuchishima, N. Hayashi, T. Saito, Y. Matsue, N. Toshikuni, T. Arisawa, J. George

Molecular Medicine (Cambridge, Mass.) 20 490-502 2014年査読有り

もっとみる

書籍等出版物

Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas.

Joseph George, Naren L. Banik, Swapan K. Ray

Ray S.K. (Editor), Springer Science/Humana Press, New York, pp. 282-298, 2010年 (ISBN: 9781441904096)
The Application of Atelocollagen Solution for Lacrimal Duct Occlusion.

Jun Onodera, Akihiko Saito, Joseph George, Toru Iwasaki, Hiroshi Ito, Yu Aso, Takashi Hamano, Atushi Kanai, Teruo Miyata, Yutaka Nagai

Kluwer Academic/Plenum Publishers, New York, pp. 1277-1281, 2002年

講演・口頭発表等

A Rat Model For Metabolic Dysfunction-Associated Fatty Liver Disease

Mutsumi Tsuchishima, Mikihiro Tsutsumi and Joseph George

The Liver Meeting, Boston 2023年11月11日
A Rat Model For Metabolic Dysfunction-Associated Fatty Liver Disease

Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi

The Liver Meeting 2023 2023年5月
Circulating long non-coding RNA HULC as an early indicator of hepatocellular carcinoma irrespective of etiology

Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi

American Association for Cancer Research Annual Meeting 2023 2023年4月14日
Albumin-billirubin score as a marker for predicting occurrence f hepato cellular carcinoma in patients with liver cirrhosis

Nobuyuki Toshikuni, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George

American Association for Cancer Research 2022 2022年4月8日
SUPPRESSION OF OXIDATIVE STRESS INHIBITED OSTEOPONTIN EXPRESSION AND PREVENTED EXPRIMENTALLY INDUCED LIVER INJURY IN RATS

Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima

American Association for the Study of Liver Diseases 2021年11月12日
Inhibition of g-glutamyl transpeptidase ameliorates hepatic ischemia/reperfusion injury in rats with fatty liiver.

Ryuichi Kubota, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George.

The Digital International Liver Congress (EASL-ILC 2020) 2020年8月27日
Recombinant thrombomodulinprevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats.

Joseph George,Yuki Hirakawa, Atsushi Fukumura, Mutsumi Tsuchishima, Mikihiro Tsutsumi.

The Digestive Disease Week (DDW 2020) 2020年5月2日
Serum miRNA-320 as a potent diagnostic biomarker for human hepatocellular carcinoma irrespective of etiology

Joseph George, Takashi Saito, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi.

The 29th Annual Convention of the Asian Pacific Association for the Study of the Liver 2020年3月5日
Diagnostic and prognostic implication of miR-27a-3p in human hepatocellular carcinoma with different etiology

Joseph George, Atsushi Fukumura, Kazuaki Ozaki, Nobuyuki Toshikuni, Mutsumi Tsuchishima, Mikihiro Tsutsumi

the Digestive Disease Week 2019年5月20日
SPP1 gene knockout in human hepatic stellate cells decreased profibrogenic cytokines and collagen gene expression

Joseph George, Takashi Saito, Nobuhiko Hayashi, Kazuaki Ozaki, Mikihiro Tsutsumi, and Mutsumi Tsuchishima

The International Liver Congress 2019年4月11日
Targeted delivery of chemotherapeutic agents employing nanovesicles effectively reduced intrahepatic tumors

Joseph George, Nobuhiko Hayashi, Takashi Saito, Mikihiro Tsutsumi, Mutsumi Tsuchishima

the 110th Annual meeting of the American Association for Cancer Research 2019年4月1日
Combination treatment with epigallocatechin gallate and silibinin restored antioxidant defense mechanisms and prevented N-nitrosodimethylamine inducedhepatic fibrosis in rats

Joseph George, Takahiro Minato, Yasuhiro Matsue, Yuki Hirakawa, Mikihiro Tsutsumi, and Mutsumi Tsuchishima

the 28th Annual Convention of the Asian Pacific Association for the Study of the Liver 2019年2月22日
Targeted delivery of epigallocatechin gallate and anti-mir221 regressed intrahepatic tumors in athymic mice

Joseph.George, Nobuhiko.Hayashi, Mikihiro.Tsutsumi, Mutsumi.Tsuchishima

DDW2018 2018年6月2日
Inhibition of γ-Glutamyl transpeptidase attenuates hepatic ischemia-reperfusion injury in rats

Joseph.George, Nobuhiko.Hayashi, Mutsumi.Tsuchishima, Mikihiro.Tsutsumi

Digestive Disease Week 2017 2017年5月6日
Nanovesicle mediated delivery of combination of anticancer agents effectively induced cell death in Hepatocellular carcinoma cell lines

J.George, N.Hayashi, T.Saito, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi

International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver 2017年4月21日
Deletion of survivin sensitize human hepatocellular carcinoma cells to low dose of doxorubicin and induce apoptosis

Joseph.George, Nobuhiko.Hayashi, Takashi.Saito, Kazuaki.Ozaki, Nobuyuki.Toshikuni, Mutsumi.Tsuchishima, Mikihiro.Tsutsumi

AACR Annual Meeting 2017 2017年4月3日
Carbohydrate-Deficient Transferrin as a useful biomarker for differentiating nonalcoholic steatohepatitis from alcoholic hepatitis.

M.Tsutsumi, J.George, N.Hayashi, M.Tsuchishima

8th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis 2013年11月
Serum endocan as a novel prognostic biomarker in hepatocellular carcinoma patients

N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi, T.Arisawa

21th United European Gastroenterology Week Berlin,Germany 2013年10月
MMP-1 トランスジェニックマウスモデルにおける肝線維化予防効果の検討

林伸彦, J.George, 松江泰弘, 湊貴浩, 齊藤隆, 福村敦, 尾崎一晶, 土島睦, 堤幹宏

第17回日本肝臓学会大会 2013年10月
Acetaldehyde-derived advanced glycation end-products promote alcholic liver disease.

J.George, N.Hayashi, M.Takeuchi, T.Arisawa, M.Tsutsumi

Digestive Disease Week 2013 2013年5月

もっとみる

ジョージジョセフ

基本情報

経歴

論文

書籍等出版物

講演・口頭発表等

所属学協会

メニュー