2014年9月
Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis
JOURNAL OF NEUROIMMUNOLOGY
- 巻
- 274
- 号
- 1-2
- 開始ページ
- 215
- 終了ページ
- 224
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jneuroim.2014.07.015
- 出版者・発行元
- ELSEVIER SCIENCE BV
We aimed to quantify the association of blood interleuldn-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR = 2.346 (1.814-3.033), p <0.0001). However, the additional predictive value of IL-6 was moderate (IDI = 1.5%, NRI = 5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose. (C) 2014 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.jneuroim.2014.07.015
- ISSN : 0165-5728
- eISSN : 1872-8421
- PubMed ID : 25091431
- Web of Science ID : WOS:000342871600029