2009年8月
Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene
EUROPEAN JOURNAL OF HAEMATOLOGY
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- 巻
- 83
- 号
- 2
- 開始ページ
- 149
- 終了ページ
- 153
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1600-0609.2009.01275.x
- 出版者・発行元
- WILEY-BLACKWELL PUBLISHING, INC
Mixed-lineage leukemia (MLL) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy-related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL-AF4 fusion transcript. MLL-AF4 is derived from t(4;11)(q21:q23) and occurs exclusively in B-cell lineage leukemia. To our knowledge, MLL-AF4 as well as t(4;11)(q21:q23) has not been reported in adult and childhood AMKL. Thus, our case provides new insight into the molecular mechanisms of MLL-AF4-associated leukemia.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1600-0609.2009.01275.x
- ISSN : 0902-4441
- PubMed ID : 19459927
- Web of Science ID : WOS:000267660200008