2018年6月1日
A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195
Nuclear Medicine and Molecular Imaging
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- 巻
- 52
- 号
- 3
- 開始ページ
- 224
- 終了ページ
- 228
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s13139-017-0510-9
© 2018, Korean Society of Nuclear Medicine. Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
- リンク情報
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- DOI
- https://doi.org/10.1007/s13139-017-0510-9
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29942401
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995778
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048488022&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85048488022&origin=inward
- ID情報
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- DOI : 10.1007/s13139-017-0510-9
- ISSN : 1869-3474
- eISSN : 1869-3482
- PubMed ID : 29942401
- PubMed Central 記事ID : PMC5995778
- SCOPUS ID : 85048488022