2008年12月
CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis
JOURNAL OF NEUROIMMUNOLOGY
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- 巻
- 205
- 号
- 1-2
- 開始ページ
- 155
- 終了ページ
- 159
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.jneuroim.2008.09.011
- 出版者・発行元
- ELSEVIER SCIENCE BV
Neurofilament (NF) is one of the major cytoskeleton proteins of neurons and sTNFR1 is thought to reflect the true biological activity of TNF-alpha. To evaluate the levels of the heavy subunit of neurofilament (NF-H) and soluble TNF receptor 1 (sTNFR1) in cerebrospinal fluid (CSF) as biomarkers of clinical severity of subacute sclerosing panencephalitis (SSPE), concentrations of NF-H and sTNFR1 in CSF of 34 patients with SSPE and in control subjects were measured by ELISA. The CSF NF-H levels were significantly higher in patients with SSPE than in controls (p<0.0001), and those in patients in Jabbour stage III were significantly higher than in patients in stage II (p=0.015). The CSF sTNFR1 levels in SSPE patients were significantly higher than those in controls (1)=0.004), but there were no significant differences in CSF sTNFR1 levels between patients in Jabbour stages II and III. There was a significant correlation between CSF NF-H and sTNFR1 levels in patients with SSPE (p=0.011). We suggest that CSF NF-H levels can be used as a marker of development of neuronal degeneration in SSPE, and that TNF-alpha modifies the neurodestructive pathogenesis in SSPE. (C) 2008 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jneuroim.2008.09.011
- ISSN : 0165-5728
- Web of Science ID : WOS:000261902200024