長谷川淳 (JUN HASEGAWA) - マイポータル

Mitigation of liquid–liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface

Tatsuji Matsuoka, Ryuki Miyauchi, Nobumi Nagaoka, Jun Hasegawa

PLOS ONE 15(10) e0240673-e0240673 2020年10月30日最終著者

Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches

Mitsuhiro Iwamoto, Takahiro Yamaguchi, Yukiko Sekiguchi, Shohei Oishi, Takeshi Shiiki, Masako Soma, Kensuke Nakamura, Makoto Yoshida, Hiroyuki Chaya, Yutaka Mori …

Bioconjugate Chemistry 29(8) 2829-2837 2018年8月15日査読有り

Generation of efficient mutants of endoglycosidase from Streptococcus pyogenes and their application in a novel one-pot transglycosylation reaction for antibody modification

Mitsuhiro Iwamoto, Yukiko Sekiguchi, Kensuke Nakamura, Yoshirou Kawaguchi, Takeshi Honda, Jun Hasegawa

PLoS ONE 13(2) e0193534-e0193534 2018年2月1日査読有り最終著者

Effects of Ionic Strength and Sugars on the Aggregation Propensity of Monoclonal Antibodies: Influence of Colloidal and Conformational Stabilities

Shuntaro Saito, Jun Hasegawa, Naoki Kobayashi, Toshiaki Tomitsuka, Susumu Uchiyama, Kiichi Fukui

Pharmaceutical Research 30(5) 1263-1280 2013年5月査読有り

Behavior of Monoclonal Antibodies: Relation Between the Second Virial Coefficient (B 2) at Low Concentrations and Aggregation Propensity and Viscosity at High Concentrations

Shuntaro Saito, Jun Hasegawa, Naoki Kobayashi, Naoyuki Kishi, Susumu Uchiyama, Kiichi Fukui

Pharmaceutical Research 29(2) 397-410 2012年2月査読有り

Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition

Nishi Hirotaka, Miyajima Makoto, Wakiyama Naoki, KUBOTA Kei, HASEGAWA Jun, UCHIYAMA Susumu, FUKUI Kiichi

Journal of bioscience and bioengineering 112(4) 326-332 2011年10月査読有り

Specific Racemization of Heavy-Chain Cysteine-220 in the Hinge Region of Immunoglobulin Gamma 1 as a Possible Cause of Degradation during Storage

Masato Amano, Jun Hasegawa, Naoki Kobayashi, Naoyuki Kishi, Takashi Nakazawa, Susumu Uchiyama, Kiichi Fukui

Analytical Chemistry 83(10) 3857-3864 2011年5月15日査読有り

Stability enhancement of cytochrome c through heme deprotonation and mutations

Takafumi Sonoyama, Jun Hasegawa, Susumu Uchiyama, Shota Nakamura, Yuji Kobayashi, Yoshihiro Sambongi

Biophysical Chemistry 139(1) 37-41 2009年1月査読有り

Structure of Cytochromec552 from a Moderate Thermophilic Bacterium,Hydrogenophilus thermoluteolus: Comparative Study on the Thermostability of Cytochromec‡

Shota Nakamura, Shin-ichi Ichiki, Hiroyuki Takashima, Susumu Uchiyama, Jun Hasegawa, Yuji Kobayashi, Yoshihiro Sambongi, Tadayasu Ohkubo

Biochemistry 45(19) 6115-6123 2006年5月査読有り

Control of the Redox Potential ofPseudomonas aeruginosaCytochromec551through the Fe−Met Coordination Bond Strength and pKaof a Buried Heme Propionic Acid Side Chain†

Shin-ichi J. Takayama, Shin-ichi Mikami, Norifumi Terui, Hajime Mita, Jun Hasegawa, Yoshihiro Sambongi, Yasuhiko Yamamoto

Biochemistry 44(14) 5488-5494 2005年4月査読有り

Cloning, expression, crystallization and preliminary X-ray characterization of cytochromec552from a moderate thermophilic bacterium,Hydrogenophilus thermoluteolus

Shin-ichi Ichiki, Shota Nakamura, Tadayasu Ohkubo, Yuji Kobayashi, Jun Hasegawa, Susumu Uchiyama, Hirofumi Nishihara, Keiko Mizuta, Yoshihiro Sambongi

Acta Crystallographica Section F Structural Biology and Crystallization Communications 61(4) 395-398 2005年4月1日査読有り

Five Amino Acid Residues Responsible for the High Stability ofHydrogenobacter thermophilusCytochromec552

Kenta Oikawa, Shota Nakamura, Takafumi Sonoyama, Atsushi Ohshima, Yuji Kobayashi, Shin-ichi J. Takayama, Yasuhiko Yamamoto, Susumu Uchiyama, Jun Hasegawa, Yoshihiro Sambongi

Journal of Biological Chemistry 280(7) 5527-5532 2005年2月18日査読有り

Complete Thermal-Unfolding Profiles of Oxidized and Reduced Cytochromes c

Susumu Uchiyama, Atsushi Ohshima, Shota Nakamura, Jun Hasegawa, Norifumi Terui, Shin-ichi Joseph Takayama, Yasuhiko Yamamoto, Yoshihiro Sambongi, Yuji Kobayashi

Journal of the American Chemical Society 126(45) 14684-14685 2004年11月査読有り

Effects of axial methionine coordination on the in-plane asymmetry of the heme electronic structure of cytochrome c

Naoki Tachiiri, Hikaru Hemmi, Shin-ichi Joseph Takayama, Hajime Mita, Jun Hasegawa, Yoshihiro Sambongi, Yasuhiko Yamamoto

JBIC Journal of Biological Inorganic Chemistry 9(6) 733-742 2004年9月査読有り

3P012 高温性水素細菌Hydrogenophilus thermoluteolus cytochrome c-552の構造と安定性の関係(蛋白質 C) 物性 : 安定性、折れたたみなど)

市来伸一, 中村昇太, 大島淳, 小林祐次, 長谷川淳, 内山進, 西原宏史, 水田啓子, 三本木至宏

生物物理 44 S192 2004年

Relationship between Redox Function and Protein Stability of Cytochromesc

Norifumi Terui, Naoki Tachiiri, Hitomi Matsuo, Jun Hasegawa, Susumu Uchiyama, Yuji Kobayashi, Yasuo Igarashi, Yoshihiro Sambongi, Yasuhiko Yamamoto

Journal of the American Chemical Society 125(45) 13650-13651 2003年11月査読有り

Influence of Amino Acid Side Chain Packing on Fe−Methionine Coordination in Thermostable Cytochromec

Yasuhiko Yamamoto, Norifumi Terui, Naoki Tachiiri, Kazuhisa Minakawa, Hitomi Matsuo, Tsunenori Kameda, Jun Hasegawa, Yoshihiro Sambongi, Susumu Uchiyama, Yuji Kobayashi …

Journal of the American Chemical Society 124(39) 11574-11575 2002年10月査読有り

Solution Structure of Ascidian Trypsin Inhibitor Determined by Nuclear Magnetic Resonance Spectroscopy†

Hikaru Hemmi, Takuya Yoshida, Takashi Kumazaki, Nobuaki Nemoto, Jun Hasegawa, Fujio Nishioka, Yoshimasa Kyogoku, Hideyoshi Yokosawa, Yuji Kobayashi

Biochemistry 41(34) 10657-10664 2002年8月査読有り

Cytochromecfrom a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability

Yoshihiro Sambongi, Susumu Uchiyama, Yuji Kobayashi, Yasuo Igarashi, Jun Hasegawa

European Journal of Biochemistry 269(14) 3355-3361 2002年7月査読有り最終著者

Thermodynamic characterization of variants of mesophilic cytochrome c and its thermophilic counterpart

Susumu Uchiyama, Jun Hasegawa, Yuko Tanimoto, Hiroshi Moriguchi, Masayuki Mizutani, Yasuo Igarashi, Yoshihiro Sambongi, Yuji Kobayashi

Protein Engineering, Design and Selection 15(6) 455-461 2002年6月査読有り

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