論文

査読有り
2016年

Antiproliferative activity of amathaspiramide alkaloids and analogs

Chemical and Pharmaceutical Bulletin
  • Jun Shimokawa
  • ,
  • Koji Chiyoda
  • ,
  • Hirotatsu Umihara
  • ,
  • Tohru Fukuyama

64
8
開始ページ
1239
終了ページ
1241
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1248/cpb.c16-00256
出版者・発行元
Pharmaceutical Society of Japan

Assisted by the total syntheses of all the amathaspiramides, six natural products and four synthetic intermediates with partially fluctuating structures were prepared and subjected to a growth inhibition assay in four human cancer cell lines. The results showed amathaspiramides A, C, and E had moderate antiproliferative activity. Examination of the structure-activity relationship revealed the importance of the amine or imine substructure on the pyrrolidine moiety and the 8R stereochemistry on the N-acyl hemiaminal moiety for the antiproliferative activity of amathaspiramide alkaloids.

リンク情報
DOI
https://doi.org/10.1248/cpb.c16-00256
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27169437
ID情報
  • DOI : 10.1248/cpb.c16-00256
  • ISSN : 1347-5223
  • ISSN : 0009-2363
  • PubMed ID : 27169437
  • SCOPUS ID : 84982704529

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