2016年
Antiproliferative activity of amathaspiramide alkaloids and analogs
Chemical and Pharmaceutical Bulletin
- ,
- ,
- ,
- 巻
- 64
- 号
- 8
- 開始ページ
- 1239
- 終了ページ
- 1241
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/cpb.c16-00256
- 出版者・発行元
- Pharmaceutical Society of Japan
Assisted by the total syntheses of all the amathaspiramides, six natural products and four synthetic intermediates with partially fluctuating structures were prepared and subjected to a growth inhibition assay in four human cancer cell lines. The results showed amathaspiramides A, C, and E had moderate antiproliferative activity. Examination of the structure-activity relationship revealed the importance of the amine or imine substructure on the pyrrolidine moiety and the 8R stereochemistry on the N-acyl hemiaminal moiety for the antiproliferative activity of amathaspiramide alkaloids.
- ID情報
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- DOI : 10.1248/cpb.c16-00256
- ISSN : 1347-5223
- ISSN : 0009-2363
- PubMed ID : 27169437
- SCOPUS ID : 84982704529