2016年7月
Criteria for deviation from predictions by the concentration addition model
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
- ,
- ,
- 巻
- 35
- 号
- 7
- 開始ページ
- 1806
- 終了ページ
- 1814
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/etc.3334
- 出版者・発行元
- WILEY-BLACKWELL
Loewe's additivity (concentration addition) is a well-known model for predicting the toxic effects of chemical mixtures under the additivity assumption of toxicity. However, from the perspective of chemical risk assessment and/or management, it is important to identify chemicals whose toxicities are additive when present concurrently, that is, it should be established whether there are chemical mixtures to which the concentration addition predictive model can be applied. The objective of the present study was to develop criteria for judging test results that deviated from the predictions by the concentration addition chemical mixture model. These criteria were based on the confidence interval of the concentration addition model's prediction and on estimation of errors of the predicted concentration-effect curves by toxicity tests after exposure to single chemicals. A log-logit model with 2 parameters was assumed for the concentration-effect curve of each individual chemical. These parameters were determined by the maximum-likelihood method, and the criteria were defined using the variances and the covariance of the parameters. In addition, the criteria were applied to a toxicity test of a binary mixture of p-n-nonylphenol and p-n-octylphenol using the Japanese killifish, medaka (Oryzias latipes). Consequently, the concentration addition model using confidence interval was capable of predicting the test results at any level, and no reason for rejecting the concentration addition was found. Environ Toxicol Chem 2016;35:1806-1814. (c) 2015 SETAC
- リンク情報
-
- DOI
- https://doi.org/10.1002/etc.3334
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26660330
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000379547900024&DestApp=WOS_CPL
- URL
- http://orcid.org/0000-0002-3471-1594
- ID情報
-
- DOI : 10.1002/etc.3334
- ISSN : 0730-7268
- eISSN : 1552-8618
- ORCIDのPut Code : 45514449
- PubMed ID : 26660330
- Web of Science ID : WOS:000379547900024