Junken Aoki

Profile Information

Affiliation: 教授 (東北大学名誉教授), 薬学系研究科, 東京大学

Degree: 薬学博士(The University of Tokyo)

Researcher number: 20250219
J-GLOBAL ID: 200901055052354690
researchmap Member ID: 6000003862

External link: http://db.tohoku.ac.jp/whois/e_detail/269b5fbf825ea70139d27a5d42e4daaa.html

Research Interests

Research Areas

Life sciences / Applied biochemistry /

Papers

475

Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate.

Masumi Oka, Sohta Akaki, Osamu Ohno, Maho Terasaki, Yuho Hamaoka-Tamura, Michiko Saito, Shinichi Kato, Asuka Inoue, Junken Aoki, Kenji Matsuno …

The Journal of pharmacology and experimental therapeutics, 389(1) 76-86, Mar 15, 2024
Structural basis for lysophosphatidylserine recognition by GPR34

Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K. Sano, Tatsuki Tanaka …

Nature Communications, 15(1), Feb 7, 2024
Group <scp>III</scp> secreted phospholipase <scp>A₂</scp>‐driven lysophospholipid pathway protects against allergic asthma

Asako Hamu‐Tanoue, Koichi Takagi, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Kuniyuki Kano, Junken Aoki, Takahiro Matsuyama, Kiyotaka Kondo, Yoichi Dotake …

The FASEB Journal, 38(2), Jan 18, 2024
New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line

Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki, Kosuke Ohsawa, Takayuki Doi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Chihiro Kawano …

The Tohoku Journal of Experimental Medicine, 2024
Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies

Mazin A. S. Abdelwahid, Kosuke Ohsawa, Akiharu Uwamizu, Kuniyuki Kano, Junken Aoki, Takayuki Doi

ACS Omega, Dec 11, 2023
Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma

Jumpei Omi, Taiga Kato, Yohei Yoshihama, Koki Sawada, Nozomu Kono, Junken Aoki

Journal of Cell Biology, 223(2), Dec 4, 2023
G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.

Naoto Kajitani, Mami Okada-Tsuchioka, Asuka Inoue, Kanako Miyano, Takeshi Masuda, Shuken Boku, Kazuya Iwamoto, Sumio Ohtsuki, Yasuhito Uezono, Junken Aoki …

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Sep 6, 2023
Chemogenetic activation of G12 signaling enhances adipose tissue browning.

Yuki Ono, Ryo Ito, Kaito Arai, Gurdeep Singh, Tsuyoshi Saitoh, Robert B Russell, Francesco Raimondi, Junken Aoki, Juro Sakai, Asuka Inoue

Signal transduction and targeted therapy, 8(1) 307-307, Aug 21, 2023
Transcriptome Profiling of Anhidrotic Eccrine Sweat Glands Reveals that Olfactory Receptors on Eccrine Sweat Glands Regulate Perspiration in a Ligand-Dependent Manner

Naoya Murayama, Takafumi Miyaki, Daisuke Okuzaki, Yasuaki Shibata, Takehiko Koji, Asuka Inoue, Junken Aoki, Hideki Hayashi, Yoshimasa Tanaka, Hiroyuki Murota

JID Innovations, 3(4) 100196-100196, Jul, 2023
Distributions of CHN compounds in meteorites record organic syntheses in the early solar system

Yoshihiro Furukawa, Daisuke Saigusa, Kuniyuki Kano, Akira Uruno, Ritsumi Saito, Motoo Ito, Megumi Matsumoto, Junken Aoki, Masayuki Yamamoto, Tomoki Nakamura

Scientific Reports, 13(1), Apr 24, 2023
Lysophospholipids and their producing enzymes: Their pathological roles and potential as pathological biomarkers.

Shun Yaginuma, Jumpei Omi, Kuniyuki Kano, Junken Aoki

Pharmacology & therapeutics, 246 108415-108415, Apr 13, 2023
Emerging roles of lysophosphatidylserine as an immune modulator.

Shun Yaginuma, Jumpei Omi, Akiharu Uwamizu, Junken Aoki

Immunological reviews, Apr 10, 2023
Exploration of LPS2 agonist binding modes using the combination of a new hydrophobic scaffold and homology modeling.

Luying Chen, Akiharu Uwamizu, Misa Sayama, Kuniyuki Kano, Yuko Otani, Sho Kondo, Asuka Inoue, Junken Aoki, Tomohiko Ohwada

European journal of medicinal chemistry, 252 115271-115271, Apr 5, 2023
Usefulness of lysophosphatidylcholine measurement in the cerebrospinal fluid for differential diagnosis of neuropathic pain: Possible introduction into clinical laboratory testing.

Makoto Kurano, Masahiko Sumitani, Yoshiyuki Akiyama, Masaki Yamada, Daiki Fujimura, Satoshi Yamaki, Kuniyuki Kano, Junken Aoki, Kentaro Hayakawa, Takuya Takahashi …

Clinica chimica acta; international journal of clinical chemistry, 541 117249-117249, Feb 15, 2023
Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease.

Takashi Shimizu, Charles R Schutt, Yoshihiro Izumi, Noriyuki Tomiyasu, Zakaria Omahdi, Kuniyuki Kano, Hyota Takamatsu, Junken Aoki, Takeshi Bamba, Atsushi Kumanogoh …

Immunity, 56(2) 307-319, Feb 14, 2023
Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.

Yuki Ono, Kouki Kawakami, Gaku Nakamura, Satoru Ishida, Junken Aoki, Asuka Inoue

Communications biology, 6(1) 112-112, Jan 28, 2023
Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84

Ryuji Ohue-Kitano, Hazuki Nonaka, Akari Nishida, Yuki Masujima, Daisuke Takahashi, Takako Ikeda, Akiharu Uwamizu, Miyako Tanaka, Motoyuki Kohjima, Miki Igarashi …

JCI Insight, 8(2), Jan 24, 2023
Improving the Signal Intensity of Cryosections Using a Conductive Adhesive Film in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Daisuke Saigusa, Ritsumi Saito, Komei Kawamoto, Akira Uruno, Kuniyuki Kano, Shuichi Shimma, Junken Aoki, Masayuki Yamamoto, Tadafumi Kawamoto

Mass Spectrometry, 2023
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity.

Masaya Ikubo, Akiharu Uwamizu, Luying Chen, Sho Nakamura, Misa Sayama, Hiroki Kawana, Yuko Otani, Kuniyuki Kano, Asuka Inoue, Junken Aoki …

Chemical & pharmaceutical bulletin, 71(7) 584-615, 2023
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.

Manae Tatsumi, Takayuki Kishi, Satoru Ishida, Hiroki Kawana, Akiharu Uwamizu, Yuki Ono, Kouki Kawakami, Junken Aoki, Asuka Inoue

PloS one, 18(1) e0280448, 2023

Misc.

652

Tricyclic antidepressants act as a G protein-biased LPA1 receptor agonist and contribute to antidepressant effects

梶谷直人, 梶谷直人, 梶谷直人, 岡田麻美, 井上飛鳥, 朴秀賢, 青木淳賢, 竹林実, 竹林実

日本生物学的精神医学会(Web), 45th, 2023
PS-PLA₁-LysoPS軸の感染症免疫における機能解析

柳沼舜, 近江純平, 可野邦行, 青木淳賢

脂質生化学研究, 65, 2023
リゾホスファチジン酸受容体LPA₃作動薬による肺線維症抑制作用メカニズムの解析

高木博那, 可野邦行, 冬室若菜, 青木淳賢

脂質生化学研究, 65, 2023
Development of separation method for hexosylceramides by time-of-flight ion mobility mass spectrometry

井上莉那, 可野邦行, 福内友子, 山岡法子, 青木淳賢, 三枝大輔, 三枝大輔

質量分析総合討論会講演要旨集, 71st, 2023
PS-PLA1-LysoPS軸の感染症免疫における機能解析

柳沼舜, 近江純平, 可野邦行, 青木淳賢

日本生化学会大会(Web), 95th, 2022
Development of Mass spectrometry techniques for peering deeper into the phospholipid diversity

可野邦行, 岩間大河, 青木淳賢

日本生化学会大会(Web), 95th, 2022
血管形成と維持におけるリゾホスファチジン酸シグナルの役割

青木淳賢, 岡里良平, 可野邦行

日本生化学会大会(Web), 95th, 2022
魚類PAQR分子のリン脂質代謝酵素としての性状解析

大西浩文, 川名裕己, 可野邦行, 河野望, 田辺弘明, 岩部(岡田)美紀, 岩部真人, 山内敏正, 横山茂之, 門脇孝 …

日本生化学会大会(Web), 95th, 2022
Exploration of differentiation-regulating phospholipids during gastrulation using MS imaging.

岩間大河, 可野邦行, 鈴木菜花, 鈴木誠, 荻野肇, 青木淳賢

衛生薬学・環境トキシコロジー講演要旨集, 2022, 2022
心筋梗塞モデルにおいてLPA₃シグナルは心臓保護的に機能する

中村真基, 可野邦行, 青木淳賢

次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 21st, 2022
アディポネクチン受容体はホスホリパーゼA₂活性によりリン脂質の不飽和化に寄与する

八木優太朗, 川名裕己, 可野邦行, 河野望, 田辺弘明, 岩部(岡田)美紀, 岩部真人, 山内敏正, 門脇孝, 横山茂之 …

次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 21st, 2022
PAQRファミリー分子は新規リン脂質代謝酵素群である

川名裕己, 大西浩文, 八木優太朗, 可野邦行, 河野望, 田辺弘明, 田辺弘明, 岩部(岡田)美紀, 岩部真人, 山内敏正 …

日本生化学会大会(Web), 95th, 2022
リゾホスファチジン酸受容体LPA3の活性化は迷走神経を介して呼吸パターンを変動させる

中村真基, 可野邦行, 青木淳賢

日本生化学会大会(Web), 95th, 2022
痒みに関与する酸化リン脂質受容体MrgB5のリガンド同定

高木祐吾, 近江純平, 可野邦行, 安部真人, 廣角道信, 河野望, 青木淳賢

日本生化学会大会(Web), 95th, 2022
アディポネクチン受容体はホスホリパーゼA2活性によりリン脂質の不飽和化に寄与する

八木優太朗, 川名裕己, 可野邦行, 河野望, 田辺弘明, 岩部(岡田)美紀, 岩部真人, 山内敏正, 門脇孝, 横山茂之 …

日本生化学会大会(Web), 95th, 2022
XIIA型分泌性ホスホリパーゼA₂はTh17細胞の分化誘導を介してTh17関連疾患を増悪する

望月茅可, 武富芳隆, 中嶋隆裕, 遠藤裕介, 可野邦行, 青木淳賢, 村上誠, 村上誠

日本生化学会大会(Web), 95th, 2022
エナメル芽細胞におけるLPA6シグナルの役割

稲葉陽, 稲葉陽, 池崎晶二郎, 熊上(坂野)深香, 荒井春乃, 荒井春乃, 東根まりい, 東根まりい, 大島勇人, 森川和政 …

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 127th, 2022
Phos-tag誘導体化法による新たな質量分析イメージング法の開発

可野邦行, 岩間大河, 青木淳賢, 青木淳賢

電気泳動(Web), 65(Suppl), 2021
質量分析イメージングによる組織リン脂質の可視化—Mapping of Phospholipid Localization on Tissue by MALDI-MS Imaging

可野邦行, 青木淳賢

脂質栄養学 = Journal of lipid nutrition / 日本脂質栄養学会編集委員会編, 30(2) 158-166, 2021
Biological significance of the fatty acid remodeling at the sn-1 position of phospholipids

青木淳賢, 川名裕己

アグリバイオ, 5(2), 2021

Research Projects

Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Elucidation of immunoregulatory roles of lysophospholipid mediators and their pharmacological significance

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
多種多様な脂肪酸種で構成されるリン脂質分子種の意義解明

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2020 - Mar, 2023

青木淳賢
Identification of synthetic pathway for lysophosphatidylserine in activated lymphocytes.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Analyses of membrane phospholipid quality

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2015 - Mar, 2020

Sasaki Takehiko
Role of lysophospholipid produced upon cell death.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019
A novel immunomodulatory role of a lysophospholipid mediator, lysophosphatidylserine,, in lynphocytes.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

AOKI JUNKEN, Ohwada Tomohiko, Yatomi Yutaka
Expansion of the study of Oxytocin Receptor, which has diverse physiological functions, and establishment of a new agonist analysing system.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

Nishimori Katsuhiko
Identification and functional analysis of a mast cell lysophosphatidylserine receptor.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Aoki Junken
Intracellular roles of 2-acyl-lysophospholipids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Aoki Junken
Immunosuppressive role of lysophosphatidylserine and its evaluation as drug targets

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Aoki Junken
Lipid machinery

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

YOKOMIZO Takehiko, AOKI Junken, MURAKAMI Makoto, MAJIMA Masataka, KIYOHARA Yutaka, SUGIMOTO Yukihiko, ARITA Makoto
The study for suppression of obliterative bronchiolitis by inhibiting autotaxin activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

YUKIKO Tando, KONDO Takashi, AOKI Junken
Comprehensive analysis of lysophospholipids using model animals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2015

AOKI Junken
Biological roles of fatty acid composition of phospholipids.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

AOKI Junken
Identification of a novel GPCR for oxidized LDL and its role in development of arteriosclerosis.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011

AOKI Junken
Comprehensive analyses of bioactive lysophospholipids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

AOKI Junken
The functions of autotaxin in the regulation of blood vessel formation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2008 - 2009

AOKI Junken
新規スレオニン含有リン脂質のマスト細胞における機能と産生機構の解明

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2007 - 2008

青木淳賢
Patho-physiological role of bioactive lysophospholipids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

AOKI Junken

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