2010年1月
DETERIORATION OF RENAL FUNCTION IN ICR-DERIVED GLOMERULONEPHRITIS (ICGN) MICE BY SUBACUTE ADMINISTRATION OF FLUORIDE IN DRINKING WATER
FLUORIDE
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- 巻
- 43
- 号
- 1
- 開始ページ
- 31
- 終了ページ
- 44
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- INT SOC FLUORIDE RESEARCH
Sodium fluoride was administered at 0, 25, 50, 100, and 150 ppm F in drinking water for 4 weeks to Institute of Cancer Research (ICR) derived glomerulonephritis (ICGN) mice. Fluoride was also administered to ICR mice at 0 and 150 ppm. Blood was sampled from the tail artery of each mouse twice a week for the determination of blood urea nitrogen (BUN) and creatinine (CRE). All ICGN mice in the 150 ppm F group and 4 of 9 in the 100 ppm F group died before the end of four weeks, but no ICR control mice died. The mean values of BUN and CRE in the serum of the 150 ppm ICGN mice were significantly higher than those in the ICGN control mice at the end of the exposure period. The mean relative liver weight of the 150 ppm ICGN mice was significantly lower than that of the ICGN control mice. We conclude that F significantly exacerbates renal dysfunction.
- リンク情報
- ID情報
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- ISSN : 0015-4725
- Web of Science ID : WOS:000278509600006