Kei Ohnuma

Profile Information

Affiliation: Graduate School of Medicine, Juntendo University

Degree: 博士（医学）(東京大学大学院)

Researcher number: 10396872
J-GLOBAL ID: 201801007274162638
researchmap Member ID: B000336033

External link: https://www.juntendo.ac.jp/graduate/laboratory/labo/immunity_cancer/

Research Areas

Committee Memberships

Papers

118

Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury.

Shun Sato, Takeshi Kawasaki, Ryo Hatano, Yu Koyanagi, Yukiko Takahashi, Kei Ohnuma, Chikao Morimoto, Steven M Dudek, Koichiro Tatsumi, Takuji Suzuki

American journal of physiology. Lung cellular and molecular physiology, Mar 12, 2024
Humanized <scp>anti‐IL</scp> ‐26 monoclonal antibody as a novel targeted therapy for chronic graft‐versus‐host disease

Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao …

American Journal of Transplantation, Aug 23, 2022
Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV

Eriko Komiya, Mitsutoshi Tominaga, Ryo Hatano, Yuji Kamikubo, Sumika Toyama, Hakushun Sakairi, Kotaro Honda, Takumi Itoh, Yayoi Kamata, Munehiro Tsurumachi …

Journal of Allergy and Clinical Immunology, 149(3) 1085-1096, Aug, 2021 Peer-reviewed
IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells

Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Mastuoka, Noriaki Iwao, Thomas M. Aune …

Cell Death & Disease, 12(6) 520-520, Jun, 2021 Peer-reviewedLast authorCorresponding author
Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody

Yutaro Kaneko, Ryo Hatano, Naoto Hirota, Nicolas Isambert, Véronique Trillet-Lenoir, Benoit You, Jérôme Alexandre, Gérard Zalcman, Fanny Valleix, Thomas Podoll …

Biomarker Research, 9(1) 21-21, Mar, 2021 Peer-reviewed
CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions

Kelsey Pan, Kei Ohnuma, Chikao Morimoto, Nam H Dang

Cureus, 13(2) e13495, Feb 22, 2021 Peer-reviewed
DPP8 is a novel therapeutic target for multiple myeloma.

Sato T, Tatekoshi A, Takada K, Iyama S, Kamihara Y, Jawaid P, Rehman MU, Noguchi K, Kondo T, Kajikawa S …

Scientific Reports, 9(1) 18094, Dec, 2019 Peer-reviewed
Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis.

Hatano R, Itoh T, Otsuka H, Okamoto S, Komiya E, Iwata S, Aune TM, Dang NH, Kuwahara-Arai K, Ohnuma K …

mAbs, Aug, 2019 Peer-reviewed
Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens.

Hatano R, Yamada T, Madokoro H, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S …

PLOS ONE, 14(6) e0218330-e0218330, 2019 Peer-reviewed
Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis.

Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M …

Journal of Investigative Dermatology, 139(4) 878-889, Nov, 2018 Peer-reviewedLast authorCorresponding author
Targeting CD26 suppresses proliferation of malignant mesothelioma cell via downmodulation of ubiquitin-specific protease 22.

Okamoto T, Yamazaki H, Hatano R, Yamada T, Kaneko Y, Xu CW, Dang NH, Ohnuma K, Morimoto C

Biochemical and biophysical research communications, 504(2) 491-498, Oct, 2018 Peer-reviewed
Rheumatic diseases associated with immune checkpoint inhibitors in cancer immunotherapy.

Ohnuma K, Hatano R, Dang NH, Morimoto C

Modern Rheumatology, 1-32, Oct, 2018 Peer-reviewedLead authorCorresponding author
IL-26を分子標的とした慢性GVHDの治療(Interleukin-26-targeted therapy for the control of chronic GVHD)

波多野良, 大塚春奈, 古宮栄利子, 伊藤匠, 岩尾憲明, 山田健人, 森本幾夫, 大沼圭

臨床血液, 59(9) 1525-1525, Sep, 2018
A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target.

Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C

Frontiers in Bioscience, 23 1754-1779, Jun, 2018 Peer-reviewed
Caveolin-1, a binding protein of CD26, is essential for the anti-inflammatory effects of dipeptidyl peptidase-4 inhibitors on human and mouse macrophages

Munenori Hiromura, Kyoko Nohtomi, Yusaku Mori, Hideo Kataoka, Marika Sugano, Kei Ohnuma, Hirotaka Kuwata, Tsutomu Hirano

Biochemical and Biophysical Research Communications, 495(1) 223-229, Jan 1, 2018 Peer-reviewed
Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target

Bently P. Doonan, Kei Ohnuma, Long H. Dang, Chikao Morimoto, Nam H. Dang

Current Cancer Therapy Reviews, 13(2), Nov 15, 2017 Peer-reviewed
Identification of senescent cell surface targetable protein DPP4

Kyoung Mi Kim, Ji Heon Noh, Monica Bodogai, Jennifer L. Martindale, Xiaoling Yang, Fred E. Indig, Sandip K. Basu, Kei Ohnuma, Chikao Morimoto, Peter F. Johnson …

GENES & DEVELOPMENT, 31(15) 1529-1534, Aug, 2017 Peer-reviewed
A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus

Eriko Komiya, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Taketo Yamada, Nam H. Dang, Mitsutoshi Tominaga, Yasushi Suga, Utako Kimura …

JOURNAL OF DERMATOLOGICAL SCIENCE, 86(3) 212-221, Jun, 2017 Peer-reviewed
First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers

Eric Angevin, Nicolas Isambert, Veronique Trillet-Lenoir, Benoit You, Jerome Alexandre, Gerard Zalcman, Philippe Vielh, Francoise Farace, Fanny Valleix, Thomas Podoll …

BRITISH JOURNAL OF CANCER, 116(9) 1126-1134, Apr, 2017 Peer-reviewed
Inhibition of VEGF-dependent angiogenesis by the anti-CD82 monoclonal antibody 4F9 through regulation of lipid raft microdomains

Sayaka Nomura, Satoshi Iwata, Ryo Hatano, Eriko Komiya, Nam H. Dang, Noriaki Iwao, Kei Ohnuma, Chikao Morimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 474(1) 111-117, May, 2016 Peer-reviewed

Misc.

CD26/dipeptidyl-peptidase IVは機械的かゆみの調節因子である

古宮栄利子, 冨永光俊, 冨永光俊, 波多野良, 外山扇雅, 伊藤匠, 鎌田弥生, 鎌田弥生, 本田耕太郎, 大沼圭 …

日本病態プロテアーゼ学会学術集会プログラム抄録集, 26th, 2021
加齢皮膚で誘発される機械的かゆみ調節機構の解明

古宮栄利子, 冨永光俊, 波多野良, 伊藤匠, 大塚春奈, 本田耕太郎, 外山扇雅, 鎌田弥生, 大沼圭, 森本幾夫 …

加齢皮膚医学セミナー, 15(1) 42-42, Jun, 2020
Chronic inflammation affects GVHD.

BIO Clinica, 8(1)(22) 128-133, Jun, 2019
機械的かゆみの調節メカニズムの解明

古宮栄利子, 松田浩則, 冨永光俊, 高森建二, 波多野良, 大塚春奈, 伊藤匠, 大沼圭, 森本幾夫, 須賀康

日本皮膚科学会雑誌, 129(4) 596-596, Apr, 2019 Peer-reviewed
CD26/dipeptidyl-peptidase IVは機械的かゆみの抑制因子である

古宮栄利子, 波多野良, 冨永光俊, 伊藤匠, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 森本幾夫 …

日本病態プロテアーゼ学会学術集会プログラム抄録集, 24th, 2019
anti-CD26 monoclonal antibody

22(2) 190-197, Aug, 2018
THE REGULATION OF PRURITUS IN PSORIASIS AND ATOPIC DERMATITIS - A POSSIBLE ROLE FOR CD26/DPPIV

Eriko Komiya-Suyama, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Yasushi Suga, Utako Kimura, Taketo Ya-Mada, Mitsutoshi Tominaga, Kenji Takamori …

ACTA DERMATO-VENEREOLOGICA, 97(8) 1008-1009, Sep, 2017
Development of new therapy for malignant mesothelioma based on CD26 molecule

Chikao Morimoto, Kei Ohnuma

Japanese Journal of Cancer and Chemotherapy, 43(7) 855-862, Jul 1, 2016 Invited
臍帯血移植によりMDSに併存したRemitting Seronegative Symmetrical Synovitis With Pitting Edema(RS3PE)も寛解に至った1例

石井敬人, 小沼貴晶, 大沼圭, 細野治, 田中廣壽, 加藤せい子, 東條有伸, 高橋聡

日本造血細胞移植学会総会プログラム・抄録集, 38th, 2016
標的別分子標的薬 6)モノクローナル抗体

大沼圭, 森本幾夫

腎臓内科・泌尿器科, 4 52-60, 2016
Clinical Significance of Soluble CD26 in Malignant Pleural Mesothelioma

Nobukazu Fujimoto, Kei Ohnuma, Keisuke Aoe, Osamu Hosono, Taketo Yamada, Takumi Kishimoto, Chikao Morimoto

JOURNAL OF THORACIC ONCOLOGY, 10(9) S200-S200, Sep, 2015 Peer-reviewed
Clinical significance of soluble CD26 in malignant pleural mesothelioma

Nobukazu Fujimoto, Kei Ohnuma, Keisuke Aoe, Osamu Hosono, Taketo Yamada, Takumi Kishimoto, Chikao Morimoto

CANCER RESEARCH, 75, Aug, 2015 Peer-reviewed
First-in-human phase I administration of YS110, a monoclonal antibody directed against the CD26 immunostimulatory molecule in advanced cancer patients.

Eric Angevin, Nicolas Isambert, Veronique N. Trillet-Lenoir, Benoit You, Jerome Alexandre, Gerard Zalcman, Philippe Viehl, Francoise Farace, Fanny Valleix, Thomas Podoll …

JOURNAL OF CLINICAL ONCOLOGY, 33(15), May, 2015 Peer-reviewed
[Antibody therapy for malignant mesothelioma: humanized anti-cD26 mAb therapy].

Morimoto C, Ohnuma K

Nihon rinsho. Japanese journal of clinical medicine, 70(12) 2177-2182, Dec, 2012
関節リウマチに対するMTX療法中に多発リンパ節腫大、好酸球増多を伴う多発関節炎再燃を来し、ステロイド治療が奏効した1例

松宮遼, 吉川賢忠, 大沼圭, 細野治, 河崎寛, 田中廣壽, 森本幾夫

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 56回・21回 560-560, Mar, 2012
免疫細胞表面抗原(CD26など)とそれらの細胞内結合分子経路

大沼圭, 森本幾夫

日本臨床, 70(Suppl 8) 176-180, 2012
CD26 Blockade by Humanized Monoclonal Antibody Leads to Prophylaxis and Treatment of Graft-Versus-Host Disease (GVHD) in Hu-PBL-NOG Model Mice

Ryo Hatano, Kei Ohnuma, Taketo Yamada, Takaaki Ooki, Junpei Yamamoto, Kaoru Komoriya, Yukiko Iwata, Nam H. Dang, Chikao Morimoto

BLOOD, 118(21) 1718-1718, Nov, 2011 Peer-reviewed
CD26を標的とした抗体療法開発へ向けて〜基礎から臨床へ〜

大沼圭, 森本幾夫

感染・炎症・免疫, 39 48-62, 2010
作用機序からみた分子標的薬〜モノクローナル抗体

大沼圭, 森本幾夫

日本臨床, 68 1841-1847, 2010
A Novel Function of CD26-Mediated Costimulation in the Cytotoxic Activity of Human CD8+T Cells in Xenogeneic Chronic Graft-Versus-Host Disease (cGVHD) and GVL Mice Model

Ryo Hatano, Kei Ohnuma, Taketo Yamada, Wataru Takasawa, Yuko Endo, Yumiko Matsumura, Osamu Hosono, Nam H. Dang, Chikao Morimoto

BLOOD, 114(22) 1376-1376, Nov, 2009 Peer-reviewed

Books and Other Publications

Advanced in Medicine and Biology

Okamoto T, Hatano R, Nakano K, Yamada T, Yamazaki H, Kaneko Y, Dang NH, Morimoto C, Ohnuma K (Role: Contributor, Regulation of proliferation of malignant mesothelioma cells by CD26-cyclophilin A molecular complex)

Nova Science Publishers Inc, 2019
Advances in Medicine and Biology

Hatano R, Ohnuma K, Yamada T, Okamoto T, Komiya E, Otsuka H, Itoh T, Yamazaki H, Iwao N, Kaneko Y, Dang NH, Morimoto C (Role: Contributor, The use of the humanized anti-CD26 monoclonal antibody YS110 as a novel targeted therapy for refractory cancers and immune disorders)

Nova Science Publishers Inc, 2018
Horizons in Cancer Research

Ohnuma K, Hatano R, Yamazaki H, Kaneko Y, Dang NH, Morimoto C (Role: Contributor, CD26 targeted therapy: A New Horizon in Malignant Pleural Mesothelioma Management)

Nova Science Publishers Inc, 2017
小児処方ノート

大沼圭 (Role: Contributor, 便秘・緩下薬)

中外医学社, Oct, 2001 (ISBN: 4498045831)
小児処方ノート

大沼圭 (Role: Contributor, 止痢薬)

中外医学社, Oct, 2001 (ISBN: 4498045831)
小児処方ノート

大沼圭 (Role: Contributor, 鎮痛薬)

中外医学社, Oct, 2001 (ISBN: 4498045831)
小児処方ノート

大沼圭 (Role: Contributor, 解熱薬)

中外医学社, Oct, 2001 (ISBN: 4498045831)
小児処方ノート

大沼圭 (Role: Contributor, HTLV-I感染症)

中外医学社, Oct, 2001 (ISBN: 4498045831)
小児処方ノート

大沼圭 (Role: Contributor, 腹痛)

中外医学社, Oct, 2001 (ISBN: 4498045831)
小児処方ノート

大沼圭 (Role: Contributor, 嘔気・嘔吐)

中外医学社, Oct, 2001 (ISBN: 4498045831)

Presentations

Possible regulation of mechanical itch by CD26/DPPIV

古宮栄利子, 波多野良, 伊藤匠, 大塚春奈, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 冨永光俊, 森本幾夫, 高森建二

10th World Congress on Itch (WCI), Nov, 2019
Possible role for CD26/DPPIV in regulating mechanical itch (Alloknesis)

古宮栄利子, 波多野良, 伊藤匠, 大塚春奈, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 冨永光俊, 森本幾夫, 高森建二

28th European Academy of Dermatology and Venereology (EADV) Congress, Oct, 2019
CD26/DPPIV regulates mechanical itch by enzymatic degradation of mu-opioid receptor ligands

古宮栄利子, 波多野良, 伊藤匠, 大塚春奈, 大沼圭, 冨永光俊, 森本幾夫, 高森建二

24th World Congress of Dermatology (WCD), Jun, 2019
Interleukin-26-targeted therapy for the control of chronic GVHD

Ryo Hatano, Haruna Otsuka, Takumi Itoh, Noriaki Iwao, Taketo Yamada, Chikao Morimoto, Kei Ohnuma

Oct, 2018
乾癬における新規炎症性サイトカインIL-26の役割と分子標的療法の開発

伊藤匠, 波多野良, 古宮栄利子, 大塚春奈, 冨永光俊, 高森建二, 森本幾夫, 大沼圭

第33回日本乾癬学会学術大会, Sep, 2018
CD26分子はDPPIV酵素活性によって乾癬のかゆみを調節する

古宮栄利子, 波多野良, 大塚春奈, 伊藤匠, 大沼圭, 冨永光俊, 森本幾夫, 高森建二

第33回日本乾癬学会学術大会, Sep, 2018
全身性エリテマトーデスのステロイド減量困難例におけるCD26陰性T細胞サブセットの増加について

波多野良, 大沼圭, 石井智徳, 伊藤匠, 岩田哲史, 奥村康, 関川巌, 森本幾夫

第62回日本リウマチ学会総会, Apr 20, 2018
難治性自己免疫疾患における新規炎症性サイトカインIL-26の役割と分子標的療法の開発

伊藤匠, 波多野良, 岩田哲史, 大沼圭, 森本幾夫

第62回日本リウマチ学会総会・学術集会, Apr, 2018
急性GVHDマウスモデルにおけるHMGB1の動態に関する検討

岩尾憲明, 大沼圭, 大塚春奈, 波多野良, 古宮栄利子, 伊藤匠, 森本幾夫

第40回日本造血幹細胞移植学会総会, Feb, 2018
全身性エリテマトーデスのステロイド治療抵抗性とCD26陰性T細胞サブセットとの関係性について

波多野良, 大沼圭, 石井智徳, 岩田哲史, 奥村康, 関川巖, 森本幾夫

第61回日本リウマチ学会総会・学術集会, Apr 20, 2017
CD26陽性T細胞サブセットに基づく全身性エリテマトーデスの病態解析

波多野良, 大沼圭, 石井智徳, 岩田哲史, 奥村康, 関川巖, 森本幾夫

第60回日本リウマチ学会総会・学術集会, Apr 22, 2016
MERS感染症について〜最新研究から考える治療と対策〜

大沼圭

第12回「熱海・湯河原・下田地区感染症対策講演会」, Dec, 2015 Invited
IL-10産生誘導によるCD26共刺激経路のnegative feedback機構の解析

波多野良, 大沼圭, 岩田哲史, 石井智徳, 関川巌, 森本幾夫

第58回日本リウマチ学会総会・学術集会, Apr, 2014
DPP4阻害薬の服用によって誘発される多関節症とそのバイオマーカー

大沼圭, 齋藤辰彦, 波多野良, 岩田哲史, 鈴木博史, 森本幾夫

第58回日本リウマチ学会総会・学術集会, Apr, 2014
Humanized anti-CD26 mAb leads to prophylaxis and treatment of GVHD in Hu-PBL-NOG model mice

波多野良, 大沼圭, 山田健人, 山本順平, 小森谷薫, Nam H Dang, 森本幾夫

第74回日本血液学会学術集会, Oct, 2012
動脈硬化「10分で悩み解決(血管エコー編)」

大沼圭

第25回市民公開医療懇談会（東大医科研附属病院）, Aug, 2012
関節リウマチに対するMTX療法中に多発リンパ節腫大、好酸球増多を伴う多発関節炎再燃を来し、ステロイド治療が奏効した1例

松宮遼, 吉川賢忠, 大沼圭, 細野治, 河崎寛, 田中廣壽, 森本幾夫

第56回日本リウマチ学会総会・学術集会, Apr, 2012
CD26 Blockade by Humanized Monoclonal Antibody Leads to Prophylaxis and Treatment of Graft-Versus-Host Disease (GVHD) in Hu-PBL-NOG Model Mice

Ryo Hatano, Kei Ohnuma, Taketo Yamada, Takaaki Ooki, Junpei Yamamoto, Kaoru Komoriya, Yukiko Iwata, Nam H. Dang, Chikao Morimoto

The 53th Annual Meeting, American Society of Hematology, Dec, 2011
A novel immunoregulation therapy targeting CD26 molecule for intractable autoimmune diseases: a new aspect of T-cell costimulation blocking therapy

Ohnuma K, Morimoto C

Tokyo- Shanghai Workshop on Rheumatology, Nov, 2011 Invited
CD26分子を用いたGVHDなど難治性免疫疾患への新規治療法開発

大沼圭

第55回日本リウマチ学会総会・学術集会, Jul, 2011

Research Projects

ヒト免疫特有の炎症性因子IL-26に基づく慢性炎症病態の解明と新規治療法の開発

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

森本幾夫, 波多野良, 大沼圭, 岩田哲史
Scientific research on development of anti-fibrotic agent targeting multi-organ profibrotic factor IL-26 in GVHD

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Kei Ohnuma
Prevention of chronic GVHD onset by HMGB1 inhibiton of DPP4

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

IWAO NORIAKI
Molecular understanding of CD26-mediated immune regulatory mechanism and development of novel molecular targeted therapy for the treatment of refractory autoimmune diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Morimoto Chikao
Mechanism of lung fibrosis in chronic GVHD

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

OHNUMA Kei
Large molecular complex of cell surface in malignant pleural mesotheliom as a novel treatment target

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

OHNUMA Kei
Role of CD26 molecule in the infection of MERS(Middle East respiratory syndrome) virus and development of new therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

MORIMOTO CHIKAO, IWATA Satoshi, OHNUMA Kei
Scientific research of transplantation tolerance targeting CD26/caveolin-1 costimulation pathway

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (S), Japan Society for the Promotion of Science, 2009 - 2013

OHNUMA Kei
新規T細胞共刺激分子CD26ーカベオリンを標的とする免疫療法開発の基礎的研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2009 - 2009

大沼圭
Basic Approach for the Development of Molecular Target Therapy for Autoimmune Diseases and Immune-Mediated Disorders.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2005 - 2009

MORIMOTO Chikao, HOSONO Osamu, IWATA Satoshi, YAMOCHI Tadanori, KAWASAKI Hiroshi, OHNUMA Kei, IKEDA Teturo
Scientific research for developing a novel immunotherapy targetinginteraction of CD26 and its ligand

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

OHNUMA Kei
Analysis of the Ro52's function and structure and biological significance of autoimmune disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

YAMOCHI Tadanori, OHNUMA Kei, HOSONO Osamu
造血幹細胞移植の合併症克服を目指したCD26による分子標的療法に関する基礎的研究

科学研究費助成事業, 若手研究(A), 日本学術振興会, 2005 - 2006

大沼圭

Industrial Property Rights

特願2021-091761 抗CD26抗体と免疫チェックポイント阻害剤との併用療法

森本幾夫, 波多野良, 大沼圭, 金子有太郎
特願2021-063781 抗癌剤への抵抗改善剤

森本幾夫, 大沼圭, 波多野良, 伊藤匠, 金子有太郞
特願2020-099449 抗癌剤への抵抗性改善剤

森本幾夫, 大沼圭, 波多野良, 伊藤匠, 金子有太郎
特願2019-004480 免疫チェックポイント阻害剤

森本幾夫大沼圭波多野良
特願2017-231439 森本幾夫大沼圭波多野良伊藤匠
特願2014-199260 免疫抑制剤

森本幾夫, 大沼圭, 波多野良
特願2015-054824 MERSコロナウイルス感染予防治療剤

森本幾夫大沼圭
特許4865868 悪性中皮腫の治療方法

森本幾夫, 大沼圭
特許WO2005063170 METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF

Morimoto C, Ohnuma K
特願2018-049308 抗ヒトCD26モノクローナル抗体

森本幾夫大沼圭波多野良山田健人
特開2015-030666 抗ヒトCD26モノクローナル抗体又はその抗原結合性断片

森本幾夫, 大沼圭, 波多野良, 山田健人

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