2005年4月
The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia.
Cancer cell
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- 巻
- 7
- 号
- 4
- 開始ページ
- 351
- 終了ページ
- 62
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
CREB is a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory. In this study, we describe a role of CREB in human cancer. CREB overexpression is associated with increased risk of relapse and decreased event-free survival. CREB levels are elevated in blast cells from patients with acute myeloid leukemia. To understand the role of CREB in leukemogenesis, we studied the biological consequences of CREB overexpression in primary human leukemia cells, leukemia cell lines, and transgenic mice. Our results demonstrate that CREB promotes abnormal proliferation and survival of myeloid cells in vitro and in vivo through upregulation of specific target genes. Thus, we report that CREB is implicated in myeloid cell transformation.
- リンク情報
- ID情報
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- ISSN : 1535-6108
- PubMed ID : 15837624