Katsuyoshi Kumagai

Profile Information

Affiliation: 助教, 疾患モデル研究センター, 東京医科大学

Degree: 博士（農学）(Mar, 2012, 東京大学)

Researcher number: 20567911
J-GLOBAL ID: 202001004407616920
researchmap Member ID: R000000989

Papers

WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7

Katsuyoshi Kumagai, Masakatsu Takanashi, Shin-ichiro Ohno, Yuichirou Harada, Koji Fujita, Keiki Oikawa, Katsuko Sudo, Shun-ichi Ikeda, Hirotaka Nishi, Kosuke Oikawa …

Oncogene, May 4, 2021
Extracellular microvesicles that originated adipose tissue derived mesenchymal stem cells have the potential ability to improve rheumatoid arthritis on mice.

Koichiro Tsujimaru, Masakatsu Takanashi, Katsuko Sudo, Akio Ishikawa, Shoichiro Mineo, Shinobu Ueda, Katsuyoshi Kumagai, Masahiko Kuroda

Regenerative therapy, 15 305-311, Dec, 2020
An improved Red/ET recombineering system and mouse ES cells culture conditions for the generation of targeted mutant mice.

Katsuyoshi Kumagai, Masakatsu Takanashi, Shin-Ichiro Ohno, Masahiko Kuroda, Katsuko Sudo

Experimental animals, 66(2) 125-136, May 3, 2017 Peer-reviewed
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.

Naoto Kubota, Tetsuya Kubota, Eiji Kajiwara, Tomokatsu Iwamura, Hiroki Kumagai, Taku Watanabe, Mariko Inoue, Iseki Takamoto, Takayoshi Sasako, Katsuyoshi Kumagai …

Nature communications, 7 12977-12977, Oct 6, 2016 Peer-reviewed
Development of novel small hairpin RNAs that do not require processing by dicer or AGO2

Shin-Ichiro Ohno, Karen Itano, Yuichirou Harada, Koutaro Asada, Keiki Oikawa, Mikie Kashiwazako, Hikaru Okuyama, Katsuyoshi Kumagai, Masakatsu Takanashi, Katsuko Sudo …

Molecular Therapy, 24(7) 1278-1289, Aug 1, 2016 Peer-reviewed
Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2.

Shin-Ichiro Ohno, Karen Itano, Yuichirou Harada, Koutaro Asada, Keiki Oikawa, Mikie Kashiwazako, Hikaru Okuyama, Katsuyoshi Kumagai, Masakatsu Takanashi, Katsuko Sudo …

Molecular therapy : the journal of the American Society of Gene Therapy, 24(7) 1278-89, Aug, 2016 Peer-reviewed
膵β細胞において2型糖尿病疾患感受性遺伝子Tcf7l2が担う役割

高本偉碩, 窪田直人, 熊谷勝義, 中屋恵三, 桜井賛孝, 小畑淳史, 岩本真彦, 窪田哲也, 北村忠弘, 植木浩二郎 …

日本内分泌学会雑誌, 90(1) 267-267, Apr, 2014
膵β細胞のTcf7l2は糖代謝と膵β細胞量を制御する

高本偉碩, 窪田直人, 熊谷勝義, 中屋恵三, 小畑淳史, 桜井賛孝, 窪田哲也, 井上真理子, 岩本真彦, 梶原栄二 …

糖尿病, 57(Suppl.1) S-256, Apr, 2014
TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass.

Iseki Takamoto, Naoto Kubota, Keizo Nakaya, Katsuyoshi Kumagai, Shinji Hashimoto, Tetsuya Kubota, Mariko Inoue, Eiji Kajiwara, Hisayuki Katsuyama, Atsushi Obata …

Diabetologia, 57(3) 542-53, Mar, 2014 Peer-reviewed
膵β細胞において2型糖尿病疾患感受性遺伝子Tcf7l2が担う役割の解明

高本偉碩, 窪田直人, 熊谷勝義, 小畑淳史, 桜井賛孝, 中屋恵三, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

日本内分泌学会雑誌, 89(1) 225-225, Apr, 2013
膵β細胞において2型糖尿病疾患感受性遺伝子Tcf7l2が担う役割の解明

高本偉碩, 窪田直人, 熊谷勝義, 小畑淳史, 桜井賛孝, 中屋恵三, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

糖尿病, 56(Suppl.1) S-251, Apr, 2013
膵β細胞においてTcf712が担う役割の解明

高本偉碩, 窪田直人, 小畑淳史, 桜井賛孝, 熊谷勝義, 中屋恵三, 勝山修行, 窪田哲也, 北村忠弘, 植木浩二郎 …

日本内分泌学会雑誌, 88(1) 247-247, Apr, 2012
新たな脂肪細胞特異的Cre発現マウスの作製と解析

桜井賛孝, 高本偉碩, 窪田直人, 熊谷勝義, 小畑淳史, 植木浩二郎, 門脇孝

糖尿病, 55(Suppl.1) S-115, Apr, 2012
2型糖尿病感受性遺伝子Tcf712が膵β細胞で担う役割の解明

高本偉碩, 窪田直人, 熊谷勝義, 小畑淳史, 桜井賛孝, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

糖尿病, 55(Suppl.1) S-297, Apr, 2012
膵β細胞のTcf7l2は膵β細胞量維持に重要な役割を果たしている

高本偉碩, 窪田直人, 小畑淳史, 熊谷勝義, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

日本体質医学会雑誌, 74(1) 20-20, Feb, 2012
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.

Keisuke Kataoka, Tomohiko Sato, Akihide Yoshimi, Susumu Goyama, Takako Tsuruta, Hiroshi Kobayashi, Munetake Shimabe, Shunya Arai, Masahiro Nakagawa, Yoichi Imai …

The Journal of experimental medicine, 208(12) 2403-16, Nov 21, 2011 Peer-reviewed
膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている

高本偉碩, 窪田直人, 小畑淳史, 熊谷勝義, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

日本体質医学会雑誌, 73(3) 213-213, Sep, 2011
膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている

高本偉碩, 窪田直人, 中屋恵三, 熊谷勝義, 小畑淳史, 勝山修行, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

糖尿病, 54(Suppl.1) S-229, Apr, 2011
Generation of transgenic mice on an NOD/SCID background using the conventional microinjection technique.

Katsuyoshi Kumagai, Naoto Kubota, Toshiki I Saito, Takayoshi Sasako, Rumi Takizawa, Katsuko Sudo, Mineo Kurokawa, Takashi Kadowaki

Biology of reproduction, 84(4) 682-8, Apr, 2011 Peer-reviewed
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

Tetsuya Kubota, Naoto Kubota, Hiroki Kumagai, Shinichi Yamaguchi, Hideki Kozono, Takehiro Takahashi, Mariko Inoue, Shinsuke Itoh, Iseki Takamoto, Takayoshi Sasako …

Cell metabolism, 13(3) 294-307, Mar 2, 2011 Peer-reviewed

Misc.

Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

Tomohiko Sato, Susumu Goyama, Keisuke Kataoka, Ryo Nasu, Takako Tsuruta-Kishino, Yuki Kagoya, Arika Nukina, Katsuyoshi Kumagai, Naoto Kubota, Masahiro Nakagawa …

CANCER RESEARCH, 74(19), Oct, 2014
Role of Tcf7l2-Mediated Pathway in Pancreatic Beta Cell In Vivo

Iseki Takamoto, Naoto Kubota, Katsuyoshi Kumagai, Atsushi Obata, Tetsuya Kubota, Kohjiro Ueki, Takashi Kadowaki

DIABETES, 61 A30-A30, Jun, 2012
Regulation of Chronic Myelogenous Leukemia Stem Cells by Leukemia Oncogene Evi1

Tomohiko Sato, Susumu Goyama, Keisuke Kataoka, Takako Tsuruta, Masahiro Nakagawa, Keiki Kumano, Katsuyoshi Kumagai, Naoto Kubota, Takashi Kadowaki, Mineo Kurokawa

BLOOD, 118(21) 440-441, Nov, 2011
膵β細胞のTcf7l2は膵β細胞量維持に重要な役割を果たしている

高本偉碩, 窪田直人, 小畑淳史, 熊谷勝義, 窪田哲也, 北村忠弘, 植木浩二郎, 門脇孝

日本体質医学会雑誌, 73(3), 2011
Evil Is a Stem Cell-Specific Regulator of Self-Renewal Capacity In the Definitive Hematopoietic System

Keisuke Kataoka, Tomohiko Sato, Akihide Yoshimi, Susumu Goyama, Takako Tsuruta, Shunya Arai, Yoichi Imai, Katsuyoshi Kumagai, Naoto Kubota, Takashi Kadowaki …

BLOOD, 116(21) 365-365, Nov, 2010
Generation of gene coding human cytokines transgenic mice with NOD/scid background by microinjection to pronucleus of the fertilized embryo

Katsuyoshi Kumagai, Rumi Takizawa, Toshiki Saito, Katsuko Sudo, Naoto Kubota, Mineo Kurokawa, Takashi Kadowaki

TRANSGENIC RESEARCH, 19(2) 336-337, Apr, 2010

Research Projects

RNA activationにおける分子機構の解析

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

大野慎一郎, 熊谷勝義, 黒田雅彦, 原田裕一郎
子宮頸癌の新規予防法開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2024

熊谷勝義, 須藤カツ子, 西洋孝, 高梨正勝, 原田裕一郎, 大野慎一郎
新規ＲＮＡ干渉核酸の探索および機能解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

大野慎一郎, 熊谷勝義, 黒田雅彦, 原田裕一郎
Function of type 2 diabetes susceptibility genes SLC16A11/13

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Hara Kazuo
Development of novel form of mimic microRNA for microRNA replacement therapy.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

OHNO Shinichiro
Physiological and pathophysiological roles of KCNQ1 as a susceptibility gene for type 2 diabetes mellitus

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Takamoto Iseki, KUBOTA Naoto, NAKAYA Keizo, KUMAGAI Katsuyoshi, KUBOTA Tetsuya, INOUE Mariko, SAKURAI Yoshitaka, IWAMOTO Masahiko, YOSHIDA Masashi, HARA Kazuo, UEKI Kohjiro, KADOWAKI Takashi
Differentiation and transplantation of insulin-secreting cells generated from mouse-derived iPS cells.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KUMAGAI Katsuyoshi
Physiological and pathophysiological roles of Tcf7l2 in pancreatic beta cells in a murine model

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

TAKAMOTO ISEKI
Physiological and pathophysiological roles of Tcf7l2 in pancreaticβ cell in type 2 diabetes

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

TAKAMOTO Iseki
Generation of tumor-bearing humanized mice that express human cytokine

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

SAITO Toshiki, KUMAGAI Katsuyoshi, HIRANO Naoto

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