Kohei Matsushita

Profile Information

Affiliation: National Institute of Health Sciences

Degree: PhD (Veterinary Science)

J-GLOBAL ID: 201801015223208881
researchmap Member ID: B000329923

Research Interests

Research Areas

Research History

Sep, 2023 - Present

室長, 病理部, 国立医薬品食品衛生研究所
Apr, 2018 - Aug, 2023

Senior Researcher, Division of Pathology, National Institute of Health Sciences
Mar, 2016 - Mar, 2018

Researcher, Division of Pathology, National Institute of Health Sciences
Apr, 2008 - Feb, 2016

Safety Research Center, Otsuka Pharmaceutical Co. Ltd.

Committee Memberships

Apr, 2024 - Present

農薬専門調査会専門委員, 内閣府食品安全委員会
Apr, 2024 - Present

評議員, 日本毒性病理学会
Apr, 2021 - Present

評議員, 日本獣医病理学専門家協会
Sep, 2019 - Present

専門委員, 独立行政法人医薬品医療機器総合機構
Aug, 2019 - Present

化審法GLP査察専門家, 厚生労働省
Feb, 2019 - Present

安衛法GLP査察専門家, 厚生労働省

Awards

Feb, 2020

年会長賞, 第36回日本毒性病理学会学術集会

松下幸平
Jan, 2020

若手優秀発表賞, 第2回医薬品毒性機序研究会

松下幸平
Mar, 2015

Encouragement award, Japanese Society of Veterinary Pathology

Kohei Matsushita
Jan, 2014

Encouragement award, Japanese Society of Toxicologic Pathology

Kohei Matsushita
Jun, 2013

Best Presentation Award, Japanese Society of Toxicology

Kohei Matsushita
Feb, 2013

The excellent presentation award (oral), The 4th Joint Workshop of Seoul University, Gifu University, and Yamaguchi University

Kohei Matsushita

Papers

Comparison of the sensitivity of histopathological and immunohistochemical analyses and blood hormone levels for early detection of antithyroid effects in rats treated with thyroid peroxidase inhibitors.

Hirotoshi Akane, Takeshi Toyoda, Kohei Matsushita, Tomomi Morikawa, Tadashi Kosaka, Hitoshi Tajima, Hiroaki Aoyama, Kumiko Ogawa

Journal of applied toxicology : JAT, Apr 2, 2024 Peer-reviewed
CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease.

Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

Journal of toxicologic pathology, 37(2) 55-67, Apr, 2024 Peer-reviewedLead authorCorresponding author
Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease.

Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

Journal of applied toxicology : JAT, 44(3) 455-469, Mar, 2024 Peer-reviewedLead authorCorresponding author
Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment.

Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Kohei Matsushita, Ken-Ichi Masumura, Takehiko Nohmi, Takashi Umemura

Mutation research. Genetic toxicology and environmental mutagenesis, 894 503729-503729, 2024 Peer-reviewed
Mucosal damage and γ-H2AX formation in the rat urinary bladder induced by aromatic amines with structures similar to o-toluidine and o-anisidine.

Takeshi Toyoda, Takuma Kobayashi, Noriyuki Miyoshi, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

Archives of toxicology, 97(12) 3197-3207, Sep 29, 2023 Peer-reviewed
A 13-week subchronic toxicity study of heme iron in SD rats.

Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 175 113702-113702, Mar 3, 2023 Peer-reviewedLead author
Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX.

Takeshi Toyoda, Mizuki Sone, Kohei Matsushita, Hirotoshi Akane, Jun-Ichi Akagi, Tomomi Morikawa, Yasuko Mizuta, Young-Man Cho, Kumiko Ogawa

The Journal of toxicological sciences, 48(6) 323-332, 2023 Peer-reviewed
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats.

Takanori Yamada, Takeshi Toyoda, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Young-Man Cho, Kumiko Ogawa

Toxicological sciences : an official journal of the Society of Toxicology, 189(1) 51-61, Aug 25, 2022 Peer-reviewed
Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.

Ken Kuroda, Yuji Ishii, Shinji Takasu, Kohei Matsushita, Aki Kijima, Takehiko Nohmi, Takashi Umemura

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 168 113365-113365, Aug 12, 2022 Peer-reviewed
Toxicological effects of two metabolites derived from o-toluidine and o-anisidine after 28-day oral administration to rats.

Takeshi Toyoda, Takuma Kobayashi, Noriyuki Miyoshi, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

The Journal of toxicological sciences, 47(11) 457-466, 2022 Peer-reviewed
A 13-week subchronic toxicity study of 2-(l-menthoxy)ethanol in F344 rats.

Takeshi Toyoda, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa

Journal of toxicologic pathology, 34(4) 309-317, Oct, 2021 Peer-reviewed
In vivo mutagenicity and tumor-promoting activity of 1,3-dichloro-2-propanol in the liver and kidneys of gpt delta rats.

Kohei Matsushita, Shinji Takasu, Yuji Ishii, Takeshi Toyoda, Takanori Yamada, Tomomi Morikawa, Kumiko Ogawa

Archives of toxicology, 95(9) 3117-3131, Jul 16, 2021 Peer-reviewedLead authorCorresponding author
Specific expression of survivin, SOX9, and CD44 in renal tubules in adaptive and maladaptive repair processes after acute kidney injury in rats.

Kohei Matsushita, Takeshi Toyoda, Takanori Yamada, Tomomi Morikawa, Kumiko Ogawa

Journal of applied toxicology : JAT, 41(4) 607-617, Apr, 2021 Peer-reviewedLead authorCorresponding author
o-Anisidine Dimer, 2-Methoxy-N4-(2-methoxyphenyl) Benzene-1,4-diamine, in Rat Urine Associated with Urinary bladder Carcinogenesis.

Takuma Kobayashi, Takeshi Toyoda, Yuya Tajima, Shinji Kishimoto, Yuta Tsunematsu, Michio Sato, Kohei Matsushita, Takanori Yamada, Yuko Shimamura, Shuichi Masuda …

Chemical research in toxicology, 34(3) 912-919, Mar 15, 2021 Peer-reviewed
Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging.

Eiichi Yamamoto, Yuhji Taquahashi, Makiko Kuwagata, Hirokatsu Saito, Kohei Matsushita, Takeshi Toyoda, Futoshi Sato, Satoshi Kitajima, Kumiko Ogawa, Ken-Ichi Izutsu …

International journal of pharmaceutics, 595 120241-120241, Feb 15, 2021 Peer-reviewed
Expression of stem cell markers as useful complementary factors in the early detection of urinary bladder carcinogens by immunohistochemistry for γ-H2AX.

Takanori Yamada, Takeshi Toyoda, Kohei Matsushita, Young-Man Cho, Jun-Ichi Akagi, Tomomi Morikawa, Yasuko Mizuta, Kumiko Ogawa

Archives of toxicology, 95(2) 715-726, Feb, 2021 Peer-reviewed
Background data of 2-year-old male and female F344 gpt delta rats.

Kohei Matsushita, Yuji Ishii, Aki Kijima, Shinji Takasu, Ken Kuroda, Hisayoshi Takagi, Takehiko Nohmi, Kumiko Ogawa, Takashi Umemura

Journal of toxicologic pathology, 34(1) 23-31, Jan, 2021 Peer-reviewedLead author
Neuromuscular and vascular hamartoma of the small intestine in an F344 rat.

Takanori Yamada, Takeshi Toyoda, Tetsuya Ide, Kohei Matsushita, Tomomi Morikawa, Kumiko Ogawa

Journal of toxicologic pathology, 34(1) 113-117, Jan, 2021 Peer-reviewed
Comprehensive expression analysis of mRNA and microRNA for the investigation of compensatory mechanisms in the rat kidney after unilateral nephrectomy.

Kohei Matsushita, Takeshi Toyoda, Takanori Yamada, Tomomi Morikawa, Kumiko Ogawa

Journal of applied toxicology : JAT, 40(10) 1373-1383, Oct, 2020 Peer-reviewedLead author
Dose dependency of γ-H2AX formation in the rat urinary bladder treated with genotoxic and nongenotoxic bladder carcinogens.

Takanori Yamada, Takeshi Toyoda, Kohei Matsushita, Tomomi Morikawa, Kumiko Ogawa

Journal of applied toxicology : JAT, 40(9) 1219-1227, Sep, 2020 Peer-reviewed

Misc.

109

脱ヨウ素酵素阻害剤によるラット抗甲状腺作用の検出に対する病理組織学的及び免疫組織化学的解析と血中ホルモン値との比較

赤根弘敏, 豊田武士, 松下幸平, 森川朋美, 小坂忠司, 田島均, 青山博昭, 小川久美子

The Journal of Toxicological Sciences, 48(Suppl.) S153-S153, Jun, 2023
シクロスポリン誘発慢性腎障害におけるCD44の役割及びバイオマーカーとしての可能性

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

The Journal of Toxicological Sciences, 48(Suppl.) S160-S160, Jun, 2023
高酸素透過性・低吸着性プレートを用いた腎スライス培養系の構築と薬物腎毒性評価への応用

角口萌乃, 荒川大, 江刺家勝弘, 松下幸平, 楊晶晶, 高橋淳, 玉井郁巳

The Journal of Toxicological Sciences, 48(Suppl.) S160-S161, Jun, 2023
シクロスポリン誘発慢性腎障害モデルラットにおけるCD44の役割

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

日本腎臓学会誌, 65(3) 339-339, May, 2023
カドミウムによる腎障害に対して時計遺伝子Per3は防御的に作用する

須崎文菜, 鳥本晋太郎, 松下幸平, 太田欣哉, 山口智広, 富永サラ, 前田徹, 松井敦聡, 稲垣直樹, 三浦伸彦 …

Fundamental Toxicological Sciences (Web), 10(Supplement), 2023
Search for the biomarker capable of predicting reversibility of drug-induced kidney injury

松下幸平

日本薬学会年会要旨集(Web), 143rd, 2023
デキストラン硫酸ナトリウム誘発ラット腸炎モデルおけるナノポリスチレンの28日間反復経口投与毒性試験

水田保子, 赤木純一, 赤根弘敏, 松下幸平, 豊田武士, 小川久美子

日本毒性病理学会講演要旨集, 39回 75-75, Jan, 2023
The role of renal tubules occurring partial EMT and relationship with CD44 in renal fibrogenesis

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

日本毒性病理学会総会及び学術集会講演要旨集, 39回 88-88, Jan, 2023
Development of an early detection method of rat renal carcinogens by immunohistochemistry for γ-H2AX

豊田武士, 松下幸平, 赤根弘敏, 森川朋美, 小川久美子

日本毒性病理学会総会及び学術集会講演要旨集, 39回 90-90, Jan, 2023
Detection of antithyroid effects of iodide uptake inhibitors in rats by histopathology and immunohistochemistry

赤根弘敏, 豊田武士, 松下幸平, 森川朋美, 小坂忠司, 田島均, 青山博昭, 小川久美子

日本毒性病理学会総会及び学術集会講演要旨集, 39回 93-93, Jan, 2023
アロプリノール誘発腎線維化モデルラットを用いた尿中CD44の腎線維化バイオマーカーとしての有用性の検証

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

The Journal of Toxicological Sciences, 47(Suppl.) S175-S175, Jun, 2022
甲状腺ホルモン代謝促進物質投与ラットにおける抗甲状腺作用の検出に対する病理組織学的及び免疫組織化学的解析と血中ホルモン値との比較

赤根弘敏, 豊田武士, 松下幸平, 森川朋美, 小坂忠司, 田島均, 青山博昭, 小川久美子

The Journal of Toxicological Sciences, 47(Suppl.) S177-S177, Jun, 2022
γ-H2AXを指標とした化学物質の腎発がん性早期検出系の開発

豊田武士, 松下幸平, 赤根弘敏, 森川朋美, 小川久美子

The Journal of Toxicological Sciences, 47(Suppl.) S194-S195, Jun, 2022
AKIからCKDへの移行におけるCD44の役割とバイオマーカーとしての応用

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

日本腎臓学会誌(Web), 64(3), 2022
ラットを用いたオリゴガラクチュロン酸の90日間亜慢性反復経口投与毒性試験

森川朋美, 豊田武士, 赤根弘敏, 松下幸平, 小川久美子

日本食品化学学会総会・学術大会講演要旨集, 28th, 2022
Comparison of histopathological and immunohistochemical methods with blood hormone levels in detection of chemical-induced antithyroid effect in rats

赤根弘敏, 豊田武士, 松下幸平, 森川朋美, 小坂忠司, 田島均, 青山博昭, 小川久美子

日本毒性病理学会講演要旨集, 38th, 2022
Potential of CD44 as a biomarker capable of predicting chronicity of drug-induced kidney injury

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

日本毒性病理学会講演要旨集, 38th, 2022
Effects of repeated oral administration of o-toluidine and o-anisidine metabolites on the rat urinary bladder

豊田武士, 小林琢磨, 三好規之, 松下幸平, 赤根弘敏, 森川朋美, 小川久美子

日本毒性病理学会講演要旨集, 38th, 2022
ラットを用いたヘム鉄の90日間亜慢性反復経口投与毒性試験

森川朋美, 豊田武士, 松下幸平, 赤根弘敏, 小川久美子

日本食品化学学会総会・学術大会講演要旨集, 27th (CD-ROM), 2021
シスプラチン誘発AKI to CKDモデルラットにおけるCD44の病態生理学的役割

松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子

日本獣医学会学術集会講演要旨集, 164th (CD-ROM), 2021

Professional Memberships

Research Projects

急性腎障害後の尿細管の再生機構破綻におけるCD44の役割解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

松下幸平
薬剤性急性腎障害から慢性腎臓病への進展を予測する新規評価分子の探索

医薬品等規制調和・評価研究事業, 国立研究開発法人日本医療研究開発機構, Jul, 2019 - Mar, 2022

松下幸平
腸管粘膜バリア破綻条件下での高分子化合物の経口暴露による毒性影響の解明

食品の安全確保推進研究事業, 厚生労働省, Apr, 2019 - Mar, 2022

井手鉄哉
The role of regenerative tubules in progression from acute kidney injury to chronic kidney disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Matsushita Kohei
レポーター遺伝子導入動物を用いたクロロプロパノール類の発がん機序の解明

食品の安全確保推進研究事業, 厚生労働省, Apr, 2018 - Mar, 2021

高須伸二
OECDプログラムにおいてTGとDAを開発するためのAOPに関する研究

化学物質リスク研究事業, 厚生労働省, Apr, 2018 - Mar, 2021

小島肇
AOPおよびIATAに立脚した国際的な安全性評価手法の確立

化学物質リスク研究事業, 厚生労働省, Apr, 2015 - Mar, 2017

西川秋佳

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