論文

査読有り
2016年

Manifestation of Latent Left Ventricular Outflow Tract Obstruction in the Acute Phase of Takotsubo Cardiomyopathy

INTERNAL MEDICINE
  • Kazuyuki Ozaki
  • ,
  • Takeshi Okubo
  • ,
  • Komei Tanaka
  • ,
  • Yukio Hosaka
  • ,
  • Keiichi Tsuchida
  • ,
  • Kazuyoshi Takahashi
  • ,
  • Hirotaka Oda
  • ,
  • Tohru Minamino

55
23
開始ページ
3413
終了ページ
3420
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.55.7119
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

Objective Left ventricular outflow tract (LVOT) obstruction is a complication in 15-25% of patients with Takotsubo cardiomyopathy and sometimes leads to catastrophic outcomes, such as cardiogenic shock or cardiac rupture. However, the underlying mechanisms have not been clarified.
Methods and Results We experienced 22 cases of Takotsubo cardiomyopathy during 3 years, and 4 of these 22 cases were complicated with LVOT obstruction in the acute phase (mean age 79 +/- 5 years, 1 man, 21 women). The LVOT pressure gradient in the acute phase was 100 +/- 17 mmHg. Transthoracic echocardiogram (TTE) revealed left ventricular hypertrophy (LVH) in one case and sigmoid-shaped septum without LVH in three cases. The complete resolution of the LVOT obstruction was achieved in a few days with normalization of the left ventricular wall motion following administration of beta-blockers. A dobutamine provocation test after normalization of the left ventricular wall motion reproduced the LVOT obstruction in all cases and revealed the presence of latent LVOT obstruction.
Conclusion The manifestation of latent LVOT obstruction in the acute phase of Takotsubo cardiomyopathy is one potential reason for the complication of LVOT obstruction with Takotsubo cardiomyopathy.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.55.7119
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27904102
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000390250000001&DestApp=WOS_CPL
ID情報
  • DOI : 10.2169/internalmedicine.55.7119
  • ISSN : 0918-2918
  • eISSN : 1349-7235
  • PubMed ID : 27904102
  • Web of Science ID : WOS:000390250000001

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