Papers

Peer-reviewed
Aug, 2017

A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis.

Acta medica Okayama
  • Takeshi Tomoda
  • Hironari Kato
  • Sho Mizukawa
  • Shinichiro Muro
  • Yutaka Akimoto
  • Daisuke Uchida
  • Kazuyuki Matsumoto
  • Naoki Yamamoto
  • Shigeru Horiguchi
  • Koichiro Tsutsumi
  • Hiroyuki Okada
  • Display all

Volume
71
Number
4
First page
357
Last page
362
Language
English
Publishing type
DOI
10.18926/AMO/55314

Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography(ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitrate might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitrate for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet. The primary endpoint is the occurrence of PEP. This study will clarify whether NSAIDs plus nitrate can prevent PEP.

Link information
DOI
https://doi.org/10.18926/AMO/55314
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28824193
ID information
  • DOI : 10.18926/AMO/55314
  • Pubmed ID : 28824193

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