Apr, 2015 - Mar, 2018
The analysis of the function and the clinical application of REIC/ Dkk-3 gene in digestive organ cancer
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 15K09001
- Grant amount
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- (Total)
- 4,680,000 Japanese Yen
- (Direct funding)
- 3,600,000 Japanese Yen
- (Indirect funding)
- 1,080,000 Japanese Yen
The reduced expression in immortalized cells REIC/the dickkopf 3 (Dkk-3) gene induced cancer selective apotosis in cell lines of hepatocellular carcinoma and cholangio cell carcinoma. REIC/Dkk‐3 expression was decreased in resected HCC tissues by immunohistochemical staining.
The REIC/DKK3 protein and peipheral blood mononuclear cells synergistically enhanced anticancer immunological effects against pancreatic cancer cells.
The clinical trial of REIC/DKK3 gene therapy for the patients with hepatocellular carcinoma started.
The REIC/DKK3 protein and peipheral blood mononuclear cells synergistically enhanced anticancer immunological effects against pancreatic cancer cells.
The clinical trial of REIC/DKK3 gene therapy for the patients with hepatocellular carcinoma started.
- Link information
- ID information
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- Grant number : 15K09001